Revolutionizing technologies of nanomicelles for combinatorial anticancer drug delivery

Jo, Min Jeong; Jin, Ik Sup; Park, Chun‐Woong; Hwang, Bang Yeon; Chung, Youn Bok; Kim, Jinseok; Shin, Dae Hwan

doi:10.1007/s12272-020-01215-4

“…At present, only liposomes have been approved for clinical use. Similar to them, the organic nano micelle, including the hydrophilic group and hydrophobic group, is simple in structure, which makes it stable and reproducible, thus easier to be used in industrial production [29][30][31]. Therefore, it is one of the promising carriers for tumor treatment.…”

Section: Discussionmentioning

confidence: 99%

Codelivery of Doxorubicin/PI3K Inhibitor Nanomicelle Linked with Phenylboronic Acid for Enhanced Cytotoxicity to Pancreatic Cancer

Zeng

¹

,

Fan

²

,

Fu

³

et al. 2022

Journal of Nanomaterials

1

0

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Multidrug combination therapy for pancreatic cancer is widely applied in clinical practice. In this study, we used phenylboronic acid and polyethylene glycol as materials of nanomicelles, loaded with the PI3K/mTORC1 dual inhibitor PF04691502 (PF) to inhibit the resistance and metastasis of pancreatic cancer and increase the sensitivity of doxorubicin (DOX). We prepared the PPD nanoparticles (NPs) with a small PDI and a uniform morphology by controlling the DOX substitution degree (size of 164.8 ± 3.6 nm and zeta potential of − 16.9 ± 0.4 mV). We determined the rates of PF and materials through the combination experiment of free drugs and the obtained PF@PPD NPs (size of 200.8 ± 2.6 nm and zeta potential of − 13.9 ± 0.3 mV). The drug loadings of DOX and PF in the nanomicelle were 14.8 ± 0.4 % and 9.5 ± 0.3 % , respectively. And the drug release in vitro was slow ( 29.17 ± 2.00 % for DOX and 39.22 ± 2.49 % for PF). The cell assay showed that the NPs had a good curative effect and migration on BxPC-3 cells, and it could be continuously taken up by cells. The PF@PPD NPs displayed a dose-dependent cytotoxicity with less cell viability ( 20.38 ± 1.11 % ) and higher uptake in BxPC-3 cells compared with the free drug. The combined medication or PF@PPD NPs reduced tumor metastasis, indicating that PF@PPD NPs had the potential for clinical application.

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“…Additionally, CPPs can promote the penetration of nano-micelles into cells to achieve better therapeutic effects. 70 The use of CPP-conjugated polymer micelles is becoming an increasingly hot topic under investigation in the field of tumour-targeted therapy. For example, researchers have successfully applied micelle systems containing TAT peptides to specifically deliver anti-cancer drugs to solid tumours and found promising experimental results.…”

Section: Nano-micellesmentioning

confidence: 99%

“…Due to inherent and easily modified characteristics, nano‐micelles are suitable for drug delivery, especially when used with CPPs. Additionally, CPPs can promote the penetration of nano‐micelles into cells to achieve better therapeutic effects 70 . The use of CPP‐conjugated polymer micelles is becoming an increasingly hot topic under investigation in the field of tumour‐targeted therapy.…”

Section: Cpps and Anti‐cancer Cargoes Deliverymentioning

confidence: 99%

The role of cell‐penetrating peptides in potential anti‐cancer therapy

Zhou

¹

,

Zou

²

,

Cheng

³

et al. 2022

Clinical & Translational Med

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Due to the complex physiological structure, microenvironment and multiple physiological barriers, traditional anti‐cancer drugs are severely restricted from reaching the tumour site. Cell‐penetrating peptides (CPPs) are typically made up of 5–30 amino acids, and can be utilised as molecular transporters to facilitate the passage of therapeutic drugs across physiological barriers. Up to now, CPPs have widely been used in many anti‐cancer treatment strategies, serving as an excellent potential choice for oncology treatment. However, their drawbacks, such as the lack of cell specificity, short duration of action, poor stability in vivo, compatibility problems (i.e. immunogenicity), poor therapeutic efficacy and formation of unwanted metabolites, have limited their further application in cancer treatment. The cellular uptake mechanisms of CPPs involve mainly endocytosis and direct penetration, but still remain highly controversial in academia. The CPPs‐based drug delivery strategy could be improved by clever design or chemical modifications to develop the next‐generation CPPs with enhanced cell penetration capability, stability and selectivity. In addition, some recent advances in targeted cell penetration that involve CPPs provide some new ideas to optimise CPPs.

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“…One of the newly conceived approaches is combinatorial therapy, a standard regimen for treating hypertension, rheumatoid arthritis, pathogenic infections, and even different kinds of cancer. Combinatorial therapy employs multiple mechanisms or the usage of two or more pharmacologically active compounds for the treatment procedure. − One of the mechanisms, adopted in combinatorial treatment, is photodynamic therapy (PDT), which is a light-induced external stimulus for treatment of varieties of infirmities. PDT is a noninvasive treatment modality that entails three essential elements such as a photosensitizer, a suitable light source, and oxygen.…”

Section: Introductionmentioning

confidence: 99%

In Vitro Therapeutic Attributes of Luminescent Hydroxyapatite Nanoparticles in Codelivery Module

Simon

¹

,

Chattopadhyay

²

,

Ghosh

³

2022

ACS Appl. Bio Mater.

2

0

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Imminent prospects of clinical importance have been accomplished through divergent treatment modalities implemented using nanoscale platforms. In the present study, hydroxyapatite nanoparticles doped with copper nanoclusters (HAPs) were explored for codelivery of a hydrophobic drug, namely, norfloxacin (NX), and a hydrophilic photosensitizer, such as methylene blue (MB). NX and MB were successfully homed into HAPs (MB-NX-HAPs), which further exhibited a pH-dependent release of both. With the objective of attaining an enhanced effect, MB-NX-HAPs were evaluated for combination therapy, involving chemotherapy and photodynamic therapy (PDT) with irradiation at 640 nm. The combinatorial therapy approach was initially applied for antibacterial therapy, which suggested a considerable reduction in bacterial growth of Gram-negative strain Pseudomonas aeruginosa MTCC 2488. Thereafter, the antiproliferative study performed in cancer cell lines (HeLa and MCF-7) revealed the efficiency of MB-NX-HAPs in bestowing a combinatorial effect through chemotherapy and PDT (irradiation at 640 nm). The combined effect exerted through MB-NX-HAPs subsequently induced reactive oxygen species (ROS) generation, cell cycle alteration, and apoptosis activation in cancer cells. The biocompatible nature of MB-NX-HAPs was appreciably shown through their minimal effect on the normal cell line (HEK-293). Additionally, HAPs through luminescence of copper nanoclusters were suggested to aid in bioimaging of cancer cell lines.

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Revolutionizing technologies of nanomicelles for combinatorial anticancer drug delivery

Cited by 24 publications

References 67 publications

Codelivery of Doxorubicin/PI3K Inhibitor Nanomicelle Linked with Phenylboronic Acid for Enhanced Cytotoxicity to Pancreatic Cancer

Codelivery of Doxorubicin/PI3K Inhibitor Nanomicelle Linked with Phenylboronic Acid for Enhanced Cytotoxicity to Pancreatic Cancer

The role of cell‐penetrating peptides in potential anti‐cancer therapy

In Vitro Therapeutic Attributes of Luminescent Hydroxyapatite Nanoparticles in Codelivery Module

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