Reward mechanism of depressive episodes in bipolar disorder: Enhanced theta power in feedback-related negativity

Wang, Xinyu; Wu, Haiyan; Huang, Jia; Gao, Chenyang; Yin, Ying; Tang, Xiaochen; Peng, Daihui

doi:10.1016/j.jad.2021.05.057

Cited by 2 publications

(4 citation statements)

References 34 publications

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“…As previously reported, the TEPS-CV has demonstrated good internal consistency and test-retest stability, and has been frequently used to study anhedonia in individuals with various conditions in China. [27][28][29][30] TEPS-CV consists of 20 questions rated on a scale from 1 (very false) to 6 (very true), with lower scores indicating more severe anhedonia. By calculating the scores of subscales, the TEPS-CV can further classify anhedonia into anticipatory (ANT) and consummatory (CON) subtypes.…”

Section: Clinical Assessmentsmentioning

confidence: 99%

“…By calculating the scores of subscales, the TEPS-CV can further classify anhedonia into anticipatory (ANT) and consummatory (CON) subtypes. [27][28][29][30]…”

Section: Clinical Assessmentsmentioning

confidence: 99%

“…Among the various paradigms for assessing anhedonia and reward processing deficits, the simple gambling task-also known as the "2-door task" or "Doors guessing task"-is a classic example that has been widely used and reported, especially when combined with neuroscience research technology 6,29,31 In this study, this paradigm was adapted and programmed using E-Prime 3.0 (Psychology Software Tools Incorporated, Pittsburgh, United States). The sketch of the study procedure is depicted in Figure 1.…”

Section: Study Paradigmmentioning

confidence: 99%

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Neural Correlates of Anhedonia in Major Depressive Disorder: Insights from Concurrent Analysis of Feedback-Related Negativity and Stimulus-Preceding Negativity

Sun,

Huang,

Gao

et al. 2023

NDT

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Purpose: Anhedonia, a core symptom of major depressive disorder (MDD), is explored in this study, focusing on the neural underpinnings through the examination of two event-related potential (ERP) components: feedback-related negativity (FRN) and stimulus-preceding negativity (SPN). Patients and Methods: This cross-sectional study was conducted in China from March 2022 to March 2023. It involved 35 MDD patients and 31 healthy controls (HC) participating in a modified 2-door task with simultaneous EEG recordings. Depression severity and anhedonia were assessed using the Hamilton Depression Scale (HAMD) and the Temporal Experience of Pleasure Scale (TEPS-CV), respectively. FRN and SPN metrics, along with correlations with each other and clinical assessments, were examined. Results: In comparison to the HC group, the MDD group exhibited significantly lower scores in TEPS-CV (t = 2.854, p = 0.006) and its subscales (t = −3.596, p = 0.001 and t = 2.434, p = 0.018, respectively), along with consistently reduced amplitudes of FRN (F 1.64= 4.726, p = 0.033) and SPN (F 1.64= 4.195, p = 0.045) across all conditions. Limited correlations were observed between ERP metrics and clinical indicators, except for positive correlations between FRN amplitudes (loss minus win) and HAMD scores (r = 0.392, p = 0.020), and SPN amplitudes after losing (SPN-L) and TEPS-CV consumption subscale scores (r = 0.357, p = 0.035). Notably, while the HC group displayed no significant FRN-SPN correlations, the MDD group exhibited positive FRN-SPN correlations under distinct conditions (r = 0.376, p = 0.026 and r = 0.355, p = 0.037, respectively). Conclusion: Our data reveal subjective and objective anhedonia in both consumption and anticipation, suggesting a shared impairment in reward feedback processing and anticipatory neural mechanisms in individuals with MDD. These findings deepen our understanding of anhedonia's neural foundations and may guide targeted interventions for this core symptom.

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Section: Clinical Assessmentsmentioning

confidence: 99%

“…By calculating the scores of subscales, the TEPS-CV can further classify anhedonia into anticipatory (ANT) and consummatory (CON) subtypes. [27][28][29][30]…”

Section: Clinical Assessmentsmentioning

confidence: 99%

Section: Study Paradigmmentioning

confidence: 99%

See 1 more Smart Citation

Neural Correlates of Anhedonia in Major Depressive Disorder: Insights from Concurrent Analysis of Feedback-Related Negativity and Stimulus-Preceding Negativity

Sun,

Huang,

Gao

et al. 2023

NDT

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“…In particular, frontal theta (4-7 Hz) synchronization is associated with highly arousing salient stimuli (positive or negative) [48,49], is most pronounced in the unconscious stage of the implicit emotional task [50,51], and facilitates the automatic top-down attention process [52]. Theta power, rooted in feedback-related negativity in bipolar disorder patients, was significantly higher in loss contexts than in gain contexts [53]. Greater frontal theta activity in adolescents with MDD predicted reduced accuracy for happy faces [54], and anhedonic participants showed a drastic increase in frontal medial theta power after receiving the maximum monetary gain [55].…”

Section: Introductionmentioning

confidence: 99%

Automatic Positive and Negative Emotion Regulation in Adolescents with Major Depressive Disorder

Zhang,

Zhao,

Tang

et al. 2023

Psychopathology

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Introduction: Adolescents with major depressive disorder (MDD) exhibit hypoactivity to positive stimuli and hyperactivity to negative stimuli in terms of neural responses. Automatic emotion regulation (AER) activates triple networks (i.e., the central control network, default mode network, and salience network). Based on previous studies, we hypothesized that adolescents with MDD exhibit dissociable spatiotemporal deficits during positive and negative AER. Methods: We first collected EEG data from 32 adolescents with MDD and 35 healthy adolescents while they performed an implicit emotional Go/NoGo task. Then, we characterized the spatiotemporal dynamics of cortical activity during AER. Results: In Go trials, MDD adolescents exhibited reduced N2 amplitudes, enhanced theta power for positive pictures, and stronger bottom-up information flow from the left orbitofrontal cortex (OFC) to the right superior frontal gyrus compared to top-down information flow than the controls. In contrast, in NoGo trials, MDD adolescents exhibited elevated P3 amplitudes, enhanced theta power, and stronger top-down information flows from the right middle frontal gyrus to the right OFC and the left insula than the controls. Conclusion: Overall, adolescents with MDD exhibited impaired automatic attention to positive emotions and impaired automatic response inhibition. These findings have potential implications for the clinical treatment of adolescents with MDD.

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Reward mechanism of depressive episodes in bipolar disorder: Enhanced theta power in feedback-related negativity

Cited by 2 publications

References 34 publications

Neural Correlates of Anhedonia in Major Depressive Disorder: Insights from Concurrent Analysis of Feedback-Related Negativity and Stimulus-Preceding Negativity

Neural Correlates of Anhedonia in Major Depressive Disorder: Insights from Concurrent Analysis of Feedback-Related Negativity and Stimulus-Preceding Negativity

Automatic Positive and Negative Emotion Regulation in Adolescents with Major Depressive Disorder

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