Reward prediction error in learning-related behaviors

Deng, Yujun; Song, Da; Ni, Junjun; Qing, Hong; Quan, Zhenzhen

doi:10.3389/fnins.2023.1171612

Cited by 4 publications

(1 citation statement)

References 117 publications

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“…The presumed discrepancy in the experience of rejected males where their innate expectation to obtain mating reward when perceiving female associated cues is unmet, resembles a well-studied neuronal mechanism known as error predication. This associative learning-based mechanism was largely studied in mammals and serves to encode a discrepancy between expected and actual rewards by sub-second-fast dopaminergic signals [110][111][112]. A recent model suggests that the Drosophila dopaminergic system harbors the capacity to encode for error prediction in a similar fashion to its mammalian counterparts [113].…”

Section: Discussionmentioning

confidence: 99%

Failure to mate enhances investment in behaviors that may promote mating reward and impairs the ability to cope with stressors via a subpopulation of Neuropeptide F receptor neurons

Ryvkin,

Omesi,

Kim

et al. 2024

PLoS Genet

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Living in dynamic environments such as the social domain, where interaction with others determines the reproductive success of individuals, requires the ability to recognize opportunities to obtain natural rewards and cope with challenges that are associated with achieving them. As such, actions that promote survival and reproduction are reinforced by the brain reward system, whereas coping with the challenges associated with obtaining these rewards is mediated by stress-response pathways, the activation of which can impair health and shorten lifespan. While much research has been devoted to understanding mechanisms underlying the way by which natural rewards are processed by the reward system, less attention has been given to the consequences of failure to obtain a desirable reward. As a model system to study the impact of failure to obtain a natural reward, we used the well-established courtship suppression paradigm in Drosophila melanogaster as means to induce repeated failures to obtain sexual reward in male flies. We discovered that beyond the known reduction in courtship actions caused by interaction with non-receptive females, repeated failures to mate induce a stress response characterized by persistent motivation to obtain the sexual reward, reduced male-male social interaction, and enhanced aggression. This frustrative-like state caused by the conflict between high motivation to obtain sexual reward and the inability to fulfill their mating drive impairs the capacity of rejected males to tolerate stressors such as starvation and oxidative stress. We further show that sensitivity to starvation and enhanced social arousal is mediated by the disinhibition of a small population of neurons that express receptors for the fly homologue of neuropeptide Y. Our findings demonstrate for the first time the existence of social stress in flies and offers a framework to study mechanisms underlying the crosstalk between reward, stress, and reproduction in a simple nervous system that is highly amenable to genetic manipulation.

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Section: Discussionmentioning

confidence: 99%

Failure to mate enhances investment in behaviors that may promote mating reward and impairs the ability to cope with stressors via a subpopulation of Neuropeptide F receptor neurons

Ryvkin,

Omesi,

Kim

et al. 2024

PLoS Genet

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Endocannabinoids modulate fear extinction controlled by a cortical-amygdala projection

Adhikari

2023

Neuron

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Associations of Reversal Learning Performance With Personality Disorder Profile and Drug Abuse History in a Sample of Prison Inmates

Martín-Ríos,

Perales,

López-Torrecillas

et al. 2024

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Prison inmate samples present a high prevalence of impulsivity- and compulsivity-related behavioral problems. The Probabilistic Reversal Learning Task (PRLT) is a useful tool to assess decision-making, and we explore its associations with inmates’ personality disorder (antisocial personality disorder, APD; obsessive-compulsive personality disorder, OCPD; or both) and history of drug abuse. Mixed-effects methods were used to model acquisition and reacquisition curves across PRLT, in a sample of 275 prison inmates diagnosed with OCPD, APD, or both. Two aspects were assessed: general discrimination learning and decision-making inflexibility. Participants with a mixed personality disorder profile showed a clear pattern of decisional inflexibility. A history of drug abuse was associated with a general poorer performance but not with decision-making inflexibility. Inability to adapt to changing contingencies, and thus to adverse consequences of previously rewarded choices, was not linked to compulsivity, as hypothesized to be present in OCPD and substance use disorders, but to the mixed APD/OCPD profile.

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Reward prediction error in learning-related behaviors

Cited by 4 publications

References 117 publications

Failure to mate enhances investment in behaviors that may promote mating reward and impairs the ability to cope with stressors via a subpopulation of Neuropeptide F receptor neurons

Failure to mate enhances investment in behaviors that may promote mating reward and impairs the ability to cope with stressors via a subpopulation of Neuropeptide F receptor neurons

Endocannabinoids modulate fear extinction controlled by a cortical-amygdala projection

Associations of Reversal Learning Performance With Personality Disorder Profile and Drug Abuse History in a Sample of Prison Inmates

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