Reward-representing D1-type neurons in the medial shell of the accumbens nucleus regulate palatable food intake

Durst, Máté; Könczöl, Katalin; Balázsa, Tamás; Eyre, Mark D.; Tóth, Zsuzsanna

doi:10.1038/s41366-018-0133-y

Cited by 41 publications

(42 citation statements)

References 54 publications

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“…Studies have shown that activation of the D1 receptor can inhibit eating of mice (Prado & Luis‐Islas, ). Durst found that intrauterine protein‐restricted mice were prone to hyperphagia, and the expression of D1 receptor in the NAc was significantly reduced (Durst, Konczol, Balazsa, Eyre, & Toth, ). Therefore, the increase in food intake in mice may be associated with a decrease in D1 receptor levels.…”

Section: Discussionmentioning

confidence: 99%

Oral supplementation with ginseng polysaccharide promotes food intake in mice

Wang

Luo

et al. 2019

Brain and Behavior

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Introduction Ginseng polysaccharide (GPS, same as Panax polysaccharide) is a kind of polysaccharide extracted from ginseng. It has been reported that GPS has the ability to activate innate immunity, regulates blood sugar balance, and improves antioxidant capacity, but the effect on feeding behavior and its mechanism remains unclear. Method To investigate the possible effect of GPS on feeding behavior of animals, mice were supplied with GPS in water, and food intake, hedonic feeding behavior, anxiety‐like behavior, expression of appetite‐regulation peptides in the central nervous system and glucose‐related hormone levels in the serum of mice were measured. Results Ginseng polysaccharide significantly increased the average daily food intake in mice and promoted hedonic eating behavior. Meanwhile, the levels of serum glucose and glucagon were significantly reduced by GPS, and GPS promoted hypothalamic neuropeptide Y expression, inhibited proopiomelanocortin (POMC) expression, and reduced dopamine D1 receptor (DRD1) levels in the midbrain. We also found that the anxiety level of mice was significantly lower after GPS intake. In conclusion, oral supplementation with GPS promoted food intake in mice, most likely through the regulation of circulating glucose levels.

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Section: Discussionmentioning

confidence: 99%

Oral supplementation with ginseng polysaccharide promotes food intake in mice

Wang

Luo

et al. 2019

Brain and Behavior

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“…Specifically, the genes are enriched to the excitatory and inhibitory cells of D1 medium spiny neurons in the striatum and stellate and basket cells in cerebellum, as well as in cortical neurons. These cells are known to indirectly regulate food-related reward processing and appetite (Durst et al, 2019;Matikainen-Ankney and Kravitz, 2018;Timper and Brüning, 2017;Vong et al, 2011).…”

Section: Transcriptomic Association Analysismentioning

confidence: 99%

Body mass variations relate to fractionated functional brain hierarchies

Park

Morys

et al. 2020

Preprint

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Variations in body mass index (BMI) have been suggested to relate to atypical brain organization, yet connectome-level substrates of BMI and their neurobiological underpinnings remain unclear. Studying 325 healthy young adults, we examined association between functional connectome organization and BMI variations. We capitalized on connectome manifold learning techniques, which represent macroscale functional connectivity patterns along continuous hierarchical axes that dissociate low level and higher order brain systems. We observed an increased differentiation between unimodal and heteromodal association networks in individuals with higher BMI, indicative of an increasingly segregated modular architecture and a disruption in the hierarchical integration of different brain system. Transcriptomic decoding and subsequent gene enrichment analyses identified genes previously implicated in genome-wide associations to BMI and specific cortical, striatal, and cerebellar cell types. These findings provide novel insights for functional connectome substrates of BMI variations in healthy young adults and point to potential molecular associations.

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“…The S35-UTPlabeled (PerForm Hungaria Kft., Budapest, Hungary) riboprobes were prepared by in vitro transcription as described previously (Konczol et al 2010;Toth et al 2008). The specific sequences used for the hybridizations were: rat prepro-PrRP cDNA (10-240 bp of the coding sequence, accession # AB015418), rat TH cDNA (684-1068 bp of the coding sequence, accession # M23598) (Mezey et al 1998), rat NUCB2 cDNA corresponding to the nesfatin-1 fragment (1-246 bp of the coding sequence, accession # DY314804) and the rat PrRP-R cDNA (189-636 bp of the coding sequence, accession # NM_139193) (Vas et al 2013;Durst et al 2019). The specificity of the cDNAs was verified by sequencing.…”

Section: In Situ Hybridizationmentioning

confidence: 99%

Colocalized neurotransmitters in the hindbrain cooperate in adaptation to chronic hypernatremia

et al. 2020

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Chronic hypernatremia activates the central osmoregulatory mechanisms and inhibits the function of the hypothalamic-pituitary-adrenal (HPA) axis. Noradrenaline (NE) release into the periventricular anteroventral third ventricle region (AV3V), the supraoptic (SON) and hypothalamic paraventricular nuclei (PVN) from efferents of the caudal ventrolateral (cVLM) and dorsomedial (cDMM) medulla has been shown to be essential for the hypernatremia-evoked responses and for the HPA response to acute restraint. Notably, the medullary NE cell groups highly coexpress prolactin-releasing peptide (PrRP) and nesfatin-1/NUCB2 (nesfatin), therefore, we assumed they contributed to the reactions to chronic hypernatremia. To investigate this, we compared two models: homozygous Brattleboro rats with hereditary diabetes insipidus (DI) and Wistar rats subjected to chronic high salt solution (HS) intake. HS rats had higher plasma osmolality than DI rats. PrRP and nesfatin mRNA levels were higher in both models, in both medullary regions compared to controls. Elevated basal tyrosine hydroxylase (TH) expression and impaired restraint-induced TH, PrRP and nesfatin expression elevations in the cVLM were, however, detected only in HS, but not in DI rats. Simultaneously, only HS rats exhibited classical signs of chronic stress and severely blunted hormonal reactions to acute restraint. Data suggest that HPA axis responsiveness to restraint depends on the type of hypernatremia, and on NE capacity in the cVLM. Additionally, NE and PrRP signalization primarily of medullary origin is increased in the SON, PVN and AV3V in HS rats. This suggests a cooperative action in the adaptation responses and designates the AV3V as a new site for PrRP's action in hypernatremia.

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Reward-representing D1-type neurons in the medial shell of the accumbens nucleus regulate palatable food intake

Abstract: Sensitivity of food reward-representing neurons in the mSh-Nac determines the level of satisfaction that governs cessation of consumption, probably through connections with the LHA. D1R signaling is a key element in this function, and is impaired in obesity-prone rats.

Cited by 41 publications

References 54 publications

Oral supplementation with ginseng polysaccharide promotes food intake in mice

Oral supplementation with ginseng polysaccharide promotes food intake in mice

Body mass variations relate to fractionated functional brain hierarchies

Colocalized neurotransmitters in the hindbrain cooperate in adaptation to chronic hypernatremia

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