Reward signals in the cerebellum: Origins, targets, and functional implications

Kostadinov, Dimitar; Häusser, Michael

doi:10.1016/j.neuron.2022.02.015

Cited by 61 publications

(40 citation statements)

References 134 publications

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“…Considering that the CS discharge during eyeblink conditioning is similar to the activity of midbrain dopamine neurons during reinforcement learning 58,59 , CF signals can encode temporal difference prediction errors 17 . Similar mechanisms can be applied to reward-based learning in the cerebellum 60,61 . However, a recent study demonstrated that PCs during reinforcement learning encode error signals in simple spikes but not in CSs 62 .…”

Section: Discussionmentioning

confidence: 99%

Cerebellar climbing fibers convey behavioral information of multiplex modalities and form functional modules

Ikezoe

Hidaka

Manita

et al. 2022

Preprint

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Cerebellar climbing fibers (CFs) convey sensorimotor information and their errors, which are used for motor control and learning. Furthermore, they represent reward-related information. Despite such functional diversity of CF signals, it is still unclear whether each CF conveys the information of single or multiple modalities and how the CFs conveying different information are distributed over the cerebellar cortex. We performed two-photon calcium imaging from cerebellar Purkinje cells (PCs) in mice engaged in a voluntary forelimb lever-pull task and demonstrated that CF responses in 93% of PCs could be explained by the combination of multiple behavioral variables, such as lever movement, licking, and reward delivery. Neighboring PCs exhibited similar CF response properties, formed functional clusters, and shared noise fluctuations of responses. Taken together, individual CFs convey behavioral information on multiplex variables and are spatially organized into the functional modules of the cerebellar cortex.

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Section: Discussionmentioning

confidence: 99%

Cerebellar climbing fibers convey behavioral information of multiplex modalities and form functional modules

Ikezoe

Hidaka

Manita

et al. 2022

Preprint

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“…The anatomically convergence of these inputs from different cerebellar modules including vermal, paravermal and hemispheric regions into the hippocampus suggests that hippocampal function may require the integration of multiple signals potentially computed at distinct cerebellar locations. These computations potentially include multi-sensory processing [133], sensory-motor combination [134,135] or even reward prediction and contingencies [136][137], a combination of these being required for optimal goal-directed behavior (see [72] for discussion). Functional investigations of the different cerebellar inputs to the hippocampus will be important to pursue in the future to understand how the outputs of these cerebellar computations are conveyed through the above-described pathways.…”

Section: Conclusion and Discussionmentioning

confidence: 99%

A Liaison Brought to Light: Cerebellum-Hippocampus, Partners for Spatial Cognition

2022

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“…Intriguingly, several recent studies have shown that the cerebellum contains reward related information 88,[96][97][98][99][100][101][102][103] . In addition to the recently described direct projection of cerebellum to one of the major reward processing brain regions, the ventral tegmental area 104 , the Cb-SNc pathway described here may also serve as a medium through which information about reward and other non-motor behaviors might be conveyed from the cerebellum to the basal ganglia.…”

Section: Discussionmentioning

confidence: 99%

Cerebellum Directly Modulates the Substantia Nigra Dopaminergic Activity

Washburn

Oñate

Yoshida

et al. 2022

Preprint

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Evidence of direct reciprocal connections between the cerebellum and basal ganglia has challenged the long-held notion that these structures function independently. While anatomical studies have suggested the presence of cerebellar projections to the substantia nigra pars compacta (SNc), the nature and function of these connections (Cb-SNc) is unknown. Here we show that the Cb-SNc form monosynaptic glutamatergic synapses with both dopaminergic and non-dopaminergic neurons in the SNc. Optogenetic activation Cb-SNc axons in the SNc rapidly increases SNc activity, elevates striatal dopamine levels, and increases the probability of locomotion. During ongoing behavior, Cb-SNc axons are bilaterally activated prior to ambulation and unilateral lever manipulation. The Cb-SNc axons show prominent activation to water reward, and higher activation for sweet water, suggesting that the pathway also encodes reward value. Thus, the cerebellum directly, rapidly, and effectively modulates basal ganglia dopamine levels and conveys information related to movement initiation, vigor, and possibly reward processing.

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Reward signals in the cerebellum: Origins, targets, and functional implications

Cited by 61 publications

References 134 publications

Cerebellar climbing fibers convey behavioral information of multiplex modalities and form functional modules

Cerebellar climbing fibers convey behavioral information of multiplex modalities and form functional modules

A Liaison Brought to Light: Cerebellum-Hippocampus, Partners for Spatial Cognition

Cerebellum Directly Modulates the Substantia Nigra Dopaminergic Activity

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