Rewarding Conversation Between Oocyte and Cumulus Cells Directs the Process of Folliculogenesis

Abstract

The process of folliculogenesis needs a balanced environment to create a mature oocyte that is expected to have characteristics in order to form the ability of a healthy fertilisation. Previous studies have been focused on endocrine effects of hypothalamic-pituitary system on ovarian functions. Influences of this system have been studied for many years. Besides of extraovarian factors, recent studies have focused on intraovarian factors which forms the relationship between oocyte and cumulus cells. It has been shown that even the maturity of antral follicule and oocyte has been effected from this communication. These factors which takes part at process of folliculogenesis, were shown to be efficient even at the success of assisted reproductive technologies. We studied general lines of this conversation based on main research articles that continue to be relevant at this topic.

Relation of serum and follicular level of GDF9 to oocyte quality, embryo quality and pregnancy rate

“…). GDF9 and BMP15 are known to be secreted only by the oocyte, essential for the process of folliculogenesis, quality of the oocyte, and female fertility, so these factors could be regarded as oocyte function biomarkers (Dayanir D. et al,2019 [10] ).…”