Rewiring Lysine Catabolism in Cancer Leads to Increased Histone Crotonylation and Immune Escape
Kosta Besermenji,
Rita Petracca
Abstract:Crotonyl‐CoA (cr‐CoA) is a metabolite derived directly from the catabolism of lysine (Lys) and tryptophan (Trp) or from the β‐oxidation of fatty acids. In glioblastoma stem cells (GSCs), histone H4 crotonylation levels are significantly elevated, which appears to positively correlate with tumor growth. This increase in crotonyl‐CoA production is attributed to the overexpression of specific Lys transporters on the cell membrane, leading to higher free lysine levels. Additionally, the overexpression of glutaryl‐… Show more
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