Reye Syndrome and Juvenile Rheumatoid Arthritis in Michigan

Pediatric cardiomyopathies over the last decade

“…Preliminary evidence also indicates that b-blocker therapy can improve left ventricular dysfunction in pediatric dilated CM [30]. Although aspirin is associated with Reye syndrome, this appears to be a dose-dependent effect of aspirin and is usually associated with doses greater than 40 mg/kg [32][33][34][35][36]. The dose of aspirin for optimal inhibition of platelet aggregation is not known, although empiric low doses of 1-5 mg/kg/day have been proposed [31].…”

Adjuvant herbal therapy for targeting susceptibility genes to Kawasaki disease: An overview of epidemiology, pathogenesis, diagnosis and pharmacological treatment of Kawasaki disease

“…The possible adverse effect resulting from the standard AAS treatment after IVIG therapy is the risk of developing Reye's syndrome (RS) in KD patients (Belay et al, 1999;Remington et al, 1985). RS occurs during the treatment of fever with drugs containing AAS, and is usually preceded by a viral infection, especially influenza and chickenpox, in children and teenagers, leading to possible lethal side effects such as toxic encephalopathy or liver dysfunction (Chornomydz et al, 2017).…”

Antithrombotic Therapy in Neonates and Children

“…40 mg/kg. [197][198][199][200][201][202] Recommendation 1.5. We suggest that when aspirin is used for antiplatelet therapy in children, it is used in doses of 1 to 5 mg/kg per day (Grade 2C) .…”