Rezidivierende Infektionen bei Patienten mit primären Immundefekten im oberen Aerodigestivtrakt

Ickrath, Pascal; Morbach, Henner; Schwaneck, Eva Christina; Gehrke, Thomas; Scherzad, Agmal; Hagen, Rudolf; Hackenberg, Stephan

doi:10.1007/s00106-019-0683-x

Cited by 7 publications

(3 citation statements)

References 19 publications

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“…Compared with studies in the normal population, our patients had a significantly higher prevalence of CRS. In a study by Ickrath et al [15] the incidence of sinusitis was 8.3%, which was lower than this study in 24 pediatric patients (mean age: 11.3) with PID [16].Immune dysfunction was investigated in CRS and treatment-resistant sinusitis, and the importance of humoral disturbances in pathogenesis was noted [15,17,18]. In the review by Mazza et al [19] PID was found to be 10-54% in treatment-resistant CRS, with the most common conditions being CVID and X-linked agammaglobulinemia [20].…”

Section: Discussionmentioning

confidence: 97%

Chronic Rhinosinusitis in Patients with Primary Immunodeficiency

Karadeniz

Aliyeva

Aydemir

et al. 2022

Int Arch Allergy Immunol

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Introduction: Primary immunodeficiencies are a heterogeneous group of diseases associated with an increased incidence of infections, autoimmunity, autoinflammatory diseases, allergies, and cancer. Rhinosinusitis is one of the most common infections in these patients. In our study, we aimed to determine the presence of chronic rhinosinusitis in our patients with primary immunodeficiency and to investigate the etiology of chronic rhinosinusitis. Methods: Forty-four patients (age range: 4–26 years) diagnosed with primary immunodeficiency were enrolled in our study. Patients were interviewed about the symptoms of chronic rhinosinusitis, and nasal endoscopic examinations were performed prospectively. The results of laboratory tests, medications, skin allergy tests, and the patients’ lung computed tomography were retrospectively recorded from patient files. Results: The distribution of patients’ diagnoses included 38.6% (n = 17) primary antibody deficiencies, 6.6% (n = 3) combined immunodeficiencies, 27.3% (n = 12) combined immunodeficiencies with syndromic features, 6.8% (n = 3) phagocytic disorders, and 20.5% (n = 9) immune dysregulation disorders. There was no significant difference in the frequency of chronic rhinosinusitis among the different immunodeficiency groups. There were no significant differences between chronic rhinosinusitis and conditions such as atopy, hypogammaglobulinemia, and treatments with immunoglobulin and/or azithromycin. The incidence of chronic rhinosinusitis was 77.8% (n = 7) in patients with a history of acute sinusitis and 20% (n = 7) in patients without a history of sinusitis, with a statistically significant difference between them (p = 0.002). Conclusion: Chronic rhinosinusitis is more common in patients with primary immunodeficiencies than in the normal population. For effective treatment, it is necessary to identify the factors that cause chronic rhinosinusitis. Further studies involving larger patient populations are needed to explain the mechanisms of chronic rhinosinusitis.

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Section: Discussionmentioning

confidence: 97%

Chronic Rhinosinusitis in Patients with Primary Immunodeficiency

Karadeniz

Aliyeva

Aydemir

et al. 2022

Int Arch Allergy Immunol

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“…Here, the adenoids probably play a role primarily as a reservoir of germs [73,74]. In cases of refractory CRS in childhood or rapidly recurring symptoms of acute or chronic rhinosinusitis, a congenital immunodeficiency must be excluded [75]. The special forms of CRS associated with cystic fibrosis and primary ciliary dyskinesia are addressed separately in the corresponding chapters of this paper.…”

Section: Etiologymentioning

confidence: 99%

“…Bei therapierefraktären CRS-Erkrankungen im Kindesalter bzw. rasch wiederkehrenden Symptomen einer akuten oder chronischen Rhinosinusitis muss ein angeborener Immundefekt ausgeschlossen werden [75]. Die Sonderformen der CRS im Zusammenhang mit einer zystischen Fibrose und einer Primären Ziliendyskinesie werden in den entsprechenden Kapiteln dieses Referats separat adressiert.…”

Section: äTiologieunclassified

Pädiatrische Rhinologie

Hackenberg,

Renson,

Röseler

et al. 2024

Laryngorhinootologie

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ZusammenfassungDer folgende Übersichtsartikel beleuchtet Schwerpunkte der pädiatrischen Rhinologie, die aktuell in der Wissenschaft und auf Tagungen sowie in der interdisziplinären Diskussion zwischen Hals-Nasen-Ohren-Heilkunde und Pädiatrie federführend thematisiert werden. Im Speziellen werden angeborene Fehlbildungen wie die Choanalatresie oder die nasalen Dermoidzysten diskutiert. Des Weiteren folgt eine Stellungnahme zum aktuellen Vorgehen bei sinugenen orbitalen Komplikationen sowie zur Diagnostik und Therapie der chronischen Rhinosinusitis bei Kindern. Im Besonderen folgen Updates zur Aufgabe des Hals-Nasen-Ohren-Arztes bei der Betreuung von Kindern mit zystischer Fibrose und Primärer Ziliendyskinesie.

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