2017
DOI: 10.4049/jimmunol.1602158
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RGC-32 Promotes Th17 Cell Differentiation and Enhances Experimental Autoimmune Encephalomyelitis

Abstract: Th17 cells play a critical role in autoimmune diseases, including multiple sclerosis and its animal model, experimental autoimmune encephalomyelitis. Response gene to complement (RGC)-32 is a cell cycle regulator and a downstream target of TGF-β that mediates its profibrotic activity. In this study, we report that RGC-32 is preferentially upregulated during Th17 cell differentiation. RGC-32−/− mice have normal Th1, Th2, and regulatory T cell differentiation but show defective Th17 differentiation in vitro. The… Show more

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Cited by 15 publications
(23 citation statements)
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“…As previously reported, RGC-32 −/− mice developed significantly less severe disease at the stage of peak disease [7] (Fig. 11a).…”
Section: Resultssupporting
confidence: 85%
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“…As previously reported, RGC-32 −/− mice developed significantly less severe disease at the stage of peak disease [7] (Fig. 11a).…”
Section: Resultssupporting
confidence: 85%
“…RGC-32 KO and WT female mice (8–10 weeks old) were injected subcutaneously in two locations in the dorsal flank with an emulsion containing 200 μg of MOG 35–55 (Anaspec, Fremont, CA) and complete Freund’s adjuvant (CFA) (Difco, Detroit, MI) as previously described [7, 15]. Pertussis toxin (400 ng; List Biological Laboratories, Campbell, CA) was administered intraperitoneally on days 0 and 2.…”
Section: Methodsmentioning
confidence: 99%
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