RGD-functionalized spherulites™ as targeted vectors captured by adherent cultured cells

Chenevier, Pascale; Delord, B.; Amédée, Joëlle; Bareille, Reine; Ichas, François; Roux, D.

doi:10.1016/s0167-4889(02)00313-0

Cited by 24 publications

(31 citation statements)

References 29 publications

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“…Therefore MLVs, which are metastable and may persist for long times, are investigated as possible containers and delivery systems for drugs and nanoparticles. [5][6][7][8][9][10][11][12][13][14] They also show potential as microreactors.…”

Section: Introductionmentioning

confidence: 99%

Planar lamellae and onions: a spatially resolved rheo–NMR approach to the shear-induced structural transformations in a surfactant model system

et al. 2011

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The shear-induced transformations between oriented planar lamellae and a state of closely packed multilamellar vesicles (MLVs) in a lyotropic nonionic surfactant model system were studied by the combination of nuclear magnetic resonance (NMR) spectroscopy and diffusometry with magnetic resonance imaging (MRI). 2H NMR imaging confirmed the discontinuous nature of the transition from onions to planar lamellae, revealing the spatial coexistence of both states within the gap of the cylindrical Couette geometry. On the other hand, NMR diffusion measurements in three principal directions and at various values of strain strongly suggest that a multi-lamellar cylindrical or undulated intermediate structure exists during the continuous and spatially homogeneous transition from planar lamellae to MLVs.

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Section: Introductionmentioning

confidence: 99%

Planar lamellae and onions: a spatially resolved rheo–NMR approach to the shear-induced structural transformations in a surfactant model system

et al. 2011

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“…In recent years, a number of studies have explored the prospects of chemical microreactors, 3 pH regulators, 4 and encapsulating fluorescent dyes inside microcapsules using the so-called spherulite 1 technology, which originated from research studies on lamellar phases under shear. 5 Specific use of onion phases to encapsulate enzymes, oligonucleotides, [6][7][8][9] and anticancer agents 10 have been explored. However, the onion phases formed by shear are out of equilibrium liquid crystalline phase and hence can revert to the equilibrium structure with time.…”

Section: Introductionmentioning

confidence: 99%

Onion Phases of PEG-8 Distearate

Redkar

Hassan

Aswal

et al. 2007

Journal of Pharmaceutical Sciences

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“…Spherulites have been shown to have several medical applications such as drug release carriers for low and high molecular weight agents with good entrapment efficiency of up to 60% 7 , targeted vectors that facilitate the internalization across specific cells when they are functionalized 8 and also as probes to study the physiological significance of amyloid spherulites formed in Alzheimer´s disease 9 . Spherulitic growth has also been observed in a number of solutions containing proteins, such as lysozyme, insulin and, most recently, interferon 10 .…”

Section: Introductionmentioning

confidence: 99%

Impact of Substrate Properties on the Formation of Spherulitic Films: A Case Study of Salbutamol Sulfate

Serrano

Mugheirbi

O’Connell

et al. 2016

Crystal Growth & Design

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Spherulitic assemblies have applications as carriers for drug delivery and as targeting vectors. Presently, the driving force behind the formation of spherulites comprising small drug molecules is not fully understood. Herein, the impact of different substrate types on spherulitic crystallization of salbutamol sulfate (SS) was investigated. Freshly cleaved mica, silicon (111) wafer (SiW), uncoated borosilicate glass (UG), silane coated glass (CG) and stainless steel (MS) were used as substrates. It was demonstrated that the spherulite growth can be controlled via the substrate selection. Spherulite formation was inhibited on hydrophilic substrates, such as mica, possibly due to stronger intermolecular interactions between SS and the substrate than SS-SS interactions. Contact angle measurements established that mica possessed the lowest contact angle (15.1±0.5°) and the values of this parameter increased in the order of UC˂SiW˂CG˂MS. Substrate roughness also played a key role in controlling spherulite formation. SiW, UC and CG had isotropic surfaces with low average roughness, facilitating spherulite formation. Overall, this work demonstrates that it is possible to successfully produce SS spherulites using a single step process at room temperature. Furthermore, the formation of SS spherulites can be tuned by the hydrophobicity of the substrate, an approach that could be applied to assembling spherulites of other small organic molecules. Presently, the driving force behind the formation of spherulites comprising small drug molecules is not fully understood. Herein, the impact of different substrate types on spherulitic crystallization of salbutamol sulfate (SS) was investigated. Freshly cleaved mica, silicon (111) wafer (SiW), uncoated borosilicate glass (UG), silane coated glass (CG) and stainless steel (MS) were used as substrates. It was demonstrated that the spherulite growth can be controlled via the substrate selection. Spherulite formation was inhibited on hydrophilic substrates, such as mica, possibly due to stronger intermolecular interactions between SS and the substrate than SS-SS interactions. Contact angle measurements established that mica possessed the lowest contact angle (15.1±0.5°) and the values of this parameter increased in the order of UC˂SiW˂CG˂MS. Substrate roughness also played a key role in controlling spherulite formation. SiW, UC and CG had isotropic surfaces with low average roughness, facilitating spherulite formation. Overall, this work demonstrates that it is possible to successfully produce SS spherulites using a single step process at room temperature. Furthermore, the formation of SS spherulites can be tuned by the hydrophobicity of the substrate, an approach that could be applied to assembling spherulites of other small organic molecules.

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RGD-functionalized spherulites™ as targeted vectors captured by adherent cultured cells

Cited by 24 publications

References 29 publications

Planar lamellae and onions: a spatially resolved rheo–NMR approach to the shear-induced structural transformations in a surfactant model system

Planar lamellae and onions: a spatially resolved rheo–NMR approach to the shear-induced structural transformations in a surfactant model system

Onion Phases of PEG-8 Distearate

Impact of Substrate Properties on the Formation of Spherulitic Films: A Case Study of Salbutamol Sulfate

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