RGD-modified ZIF-8 nanoparticles as a drug carrier for MR imaging and targeted drug delivery in myocardial infarction

Li, Yingxu; Tuerhan, Maisituremu; Li, Bing; Chen, Shuangling; Wang, Yuji; Zheng, Yuanyuan

doi:10.1080/17435889.2024.2365623

Nanomedicine

2024

DOI: 10.1080/17435889.2024.2365623

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RGD-modified ZIF-8 nanoparticles as a drug carrier for MR imaging and targeted drug delivery in myocardial infarction

Yingxu Li,

Maisituremu Tuerhan,

Bing Li

et al.

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Engineering pH and Temperature-Triggered Drug Release with Metal-Organic Frameworks and Fatty Acids

Wei,

2024

Molecules

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This study reports the successful synthesis of core-shell microparticles utilizing coaxial electrospray techniques, with zeolitic imidazolate framework-8 (ZIF-8) encapsulating rhodamine B (RhB) in the core and a phase change material (PCM) shell composed of a eutectic mixture of lauric acid (LA) and stearic acid (SA). ZIF-8 is well-recognized for its pH-responsive degradation and biocompatibility, making it an ideal candidate for targeted drug delivery. The LA-SA PCM mixture, with a melting point near physiological temperature (39 °C), enables temperature-triggered drug release, enhancing therapeutic precision. The structural properties of the microparticles were extensively characterized through scanning electron microscopy (SEM), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), and thermogravimetric analysis (TGA). Drug release studies revealed a dual-stimuli response, where the release of RhB was significantly influenced by both temperature and pH. Under mildly acidic conditions (pH 4.0) at 40 °C, a rapid and complete release of RhB was observed within 120 h, while at 37 °C, the release rate was notably slower. Specifically, the release at 40 °C was 79% higher than at 37 °C, confirming the temperature sensitivity of the system. Moreover, at physiological pH (7.4), minimal drug release occurred, demonstrating the system’s potential for minimizing premature drug release under neutral conditions. This dual-stimuli approach holds promise for improving therapeutic outcomes in cancer treatment by enabling precise control over drug release in response to both pH and localized hyperthermia, reducing off-target effects and improving patient compliance.

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Engineering pH and Temperature-Triggered Drug Release with Metal-Organic Frameworks and Fatty Acids

Wei,

2024

Molecules

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show abstract

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RGD-modified ZIF-8 nanoparticles as a drug carrier for MR imaging and targeted drug delivery in myocardial infarction

Cited by 1 publication

References 60 publications

Engineering pH and Temperature-Triggered Drug Release with Metal-Organic Frameworks and Fatty Acids

Engineering pH and Temperature-Triggered Drug Release with Metal-Organic Frameworks and Fatty Acids

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