RGH-5702 a new mucosal mast cell protector antiulcer drug

Ezer, E.; Matuz, J.; Sághy, Katalin; Szporny, L; Nakamura, Mitsuki; Szabadkai, István; Harsányi, Kálmán

doi:10.1016/0014-2999(90)93147-i

Cited by 1 publication

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“…For related literature, see : Brackmann et al (2005); Ezer et al (1984); Ford & Casida (2006); Liu et al (2006); Mota-Sanchez et al (2006); Ogawa et al (1992); Schmuck (2001); Shiokawa et al (1990); Yoneda et al (2001); Zhang et al (2000).…”

Section: Related Literaturementioning

confidence: 99%

“…Recently, compounds containing 2-cyanoimino-thiazolidine group have attracted much interest because they exhibit diverse biological activities, such as antiulcer, vasodilator, antihypertensive and insecticidal activities (Ezer et al, 1984;Shiokawa et al, 1990;Ogawa et al, 1992;Zhang et al, 2000). They are widely applied in the fields of medication and plant protection (Yoneda et al, 2001;Schmuck, 2001;Ford & Casida, 2006).…”

Section: Commentmentioning

confidence: 99%

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(Benzoyl)[2-(cyanoimino)-1,3-thiazolidin-2-yl]methyl acetate

Dai

Zhang

et al. 2007

Acta Cryst E

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Key indicators: single-crystal X-ray study; T = 294 K; mean (C-C) = 0.004 Å; R factor = 0.043; wR factor = 0.119; data-to-parameter ratio = 13.7.The title compound, C 14 H 13 N 3 O 3 S, has been synthesized as a potent fungicidal agent. The 1,3-thiazolidine ring is approximately planar and makes a dihedral angle of 84.9 (2) with the phenyl ring. There are weak intramolecular C-HÁ Á ÁO and C-HÁ Á ÁN hydrogen bonds, which stabilize the molecular structure. Related literatureFor related literature, see: Brackmann et al. (2005); Ezer et al. Experimental Crystal data C 14 H 13 N 3 O 3 S M r = 303.33 Monoclinic, P2 1 =n a = 8.4679 (19) Å b = 8.713 (2) Å c = 20.147 (5) Å = 91.565 (4) V = 1486.0 (6) Å 3 Z = 4 Mo K radiation = 0.23 mm À1 T = 294 (2) K 0.22 Â 0.18 Â 0.12 mm Data collectionBruker SMART 1000 diffractometer Absorption correction: multi-scan (SADABS;Sheldrick, 1996) T min = 0.951, T max = 0.963 7441 measured reflections 2620 independent reflections 1807 reflections with I > 2(I) R int = 0.032

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