RGTA® or ReGeneraTing Agents mimic heparan sulfate in regenerative medicine: from concept to curing patients

Abstract

The importance of extracellular matrix (ECM) integrity in maintaining normal tissue function is highlighted by numerous pathologies and situations of acute and chronic injury associated with dysregulation or destruction of ECM components. Heparan sulfate (HS) is a key component of the ECM, where it fulfils important functions associated with tissue homeostasis. Its degradation following tissue injury disrupts this delicate equilibrium and may impair the wound healing process. ReGeneraTing Agents (RGTA®s) are polysaccharides specifically designed to replace degraded HS in injured tissues. The unique properties of RGTA® (resistance to degradation, binding and protection of ECM structural and signaling proteins, like HS) permit the reconstruction of the ECM, restoring both structural and biochemical functions to this essential substrate, and facilitating the processes of tissue repair and regeneration. Here, we review 25 years of research surrounding this HS mimic, supporting the mode of action, pre-clinical studies and therapeutic efficacy of RGTA® in the clinic, and discuss the potential of RGTA® in new branches of regenerative medicine.

ReGeneraTing Agents (RGTA®): A new option for healing and improving treatment outcomes for traumatic and burn injuries of the hand

“…RGTA ® s are chemically engineered polymers that are specifically designed to replace degraded Heparan Sulfate (HS) in the injured extracellular matrix. They protect naturally existing structural and signaling proteins by sequestering proteins through low‐affinity binding, allowing for faster and high‐quality tissue repair . Their unique properties have been the subject of intensive preclinical and clinical studies .…”

“…Their unique properties have been the subject of intensive preclinical and clinical studies . CACIPLIQ20 ® contains RGTA ® OTR4120, a biodegradable polymer of 1‐6 alpha polyglucose substituted carboxymethyl and sulfated …”

“…They protect naturally existing structural and signaling proteins by sequestering proteins through low-affinity binding, allowing for faster and highquality tissue repair. 3 Their unique properties have been the subject of intensive preclinical and clinical studies. 1,2,5-14 CACIPLIQ20 ® contains RGTA ® OTR4120, a biodegradable polymer of 1-6 alpha polyglucose substituted carboxymethyl and sulfated.…”

“…1,2,5-14 CACIPLIQ20 ® contains RGTA ® OTR4120, a biodegradable polymer of 1-6 alpha polyglucose substituted carboxymethyl and sulfated. 3 12 minutes. The gauze was then removed, and the wound was covered with a non-occlusive dressing.…”

“…We had the opportunity in our clinic to use a type of matrix therapy, commercially known as CACIPLIQ20 ® , which is recommended to treat chronic wounds . Matrix therapy using RGTA ® (ReGeneraTing Agent) is an innovative, minimally invasive approach in the field of regenerative medicine that aims to promote tissue regeneration by reconstructing the cellular microenvironment following tissue injuries . CACIPLIQ20 ® contains OTR4120, a RGTA ® specifically formulated for skin and plastic surgery, which replaces degraded Heparan Sulfate (HS) in the injured extracellular matrix…”