Rh‐Catalyzed CH Functionalization with Alkene

Abstract

Rhodium‐catalyzed CH functionalization of alkenes has been summarized in this article. This article distinguished the alkenes (olefins) broadly into two categories, namely activated olefins and unactivated olefins, based on their polarizability. This article also highlights the recent advancements in Rh‐catalyzed CH functionalization using olefins as coupling partners and their reactivity in the presence of various directing groups. Besides, this article focuses on the mode of transformations and the possible mechanistic aspect under rhodium‐catalysis.

Recent advances in Rh(i)-catalyzed enantioselective C–H functionalization

“…investigated in asymmetric C-H functionalization with diverse mechanisms. [32][33][34][35][36][37][38][39][40][41][42][43][44][45] From the viewpoint of substrate activation modes, Rh-catalyzed C-H functionalization could be classified into two categories: inner-sphere mechanism and outer-sphere mechanism, which differ in the mechanism of the C-H activation step (Scheme 1). 46,47 Generally, Rh(III)-catalyzed asymmetric C-H functionalization adopts the inner-sphere mechanism by taking advantage of a chiral cyclopentadienyl (Cp) ligand, 35,38,39,[48][49][50][51] whereas Rh(II) usually coordinates with a chiral carboxylic acid to achieve the effect of asymmetric C-H functionalization via the outer-sphere mechanism, 14,[52][53][54] both of which have been well reviewed elsewhere.…”