Rh(iii)-catalyzed selective mono- and dual-functionalization/cyclization of 1-aryl-5-aminopyrazoles with iodonium ylides

Abstract

Highly functionalized benzodiazepine skeletons were efficiently synthesized via a Rh(iii)-catalyzed selective mono- and dual-C–H bond functionalization/cyclization reaction between readily available 1-aryl-5-aminopyrazoles and iodonium ylides under.

Electrocatalytic C–H/S–H Coupling of Amino Pyrazoles and Thiophenols: Synthesis of Amino Pyrazole Thioether Derivatives

“…Organosulfur compounds widely exist in pharmaceutical molecules and serve as important scaffolds for various transformations in organic synthesis . Generally, notable bioactivities can be obtained with the incorporation of aryl sulfide into a heterocyclic compound via C–S formation .…”

Rh(iii)-catalyzed C(sp2)–H functionalization/[4+2] annulation of oxadiazolones with iodonium ylides to access diverse fused-isoquinolines and fused-pyridines

“…13 At present, as stable carbene precursors, iodonium ylides have drawn great interest in the construction of carbon–carbon coupling reactions and heterocycle annulation through metal carbene intermediates (Scheme 1b). 14 On the other hand, iodonium ylides have been applied as both nucleophiles and electrophiles in various organic substitution reactions. 15 Furthermore, their applications in single-electron transfer (SET) processes have also been reported.…”