Rhabdoid papillary meningioma: A clinicopathologic case series study

Abstract

World Health Organization (WHO) grade III meningiomas are subclassified on the basis of their architectural pattern into papillary and rhabdoid subtypes. Some meningiomas even combine papillary architecture with rhabdoid cytology. Additionally, they always show malignant histological features, follow an aggressive clinical course and tend to spread through the CSF after frequent local recurrence. We render the first series of rhabdoid papillary meningioma with review of the literature to further elucidate its biological behavior. From six patients (three male, three female), nine specimens of rhabdoid papillary meningioma were obtained between 1994 and 2010. Correlations of histologic parameters, immunohistochemical study, and clinical features were assessed. The mean age of patients was 44.7 years at their first operation. The mean postoperative follow-up period was 63.2 months. Five patients experienced tumor recurrence, and one of them died from the disease after diffuse leptomeningeal dissemination. The mean time to first recurrence was 28 months. Only one patient was free of tumoral recurrence after an 8-year follow-up. Immunohistochemically, all tumors were positive for vimentin and epithelial membrane antigen. MIB-1 labeling indices were higher following tumor recurrence. The present study expands the clinicopathologic horizon of rhabdoid papillary meningioma and suggests that it will behave aggressively based on its histology and concomitant features of atypia or malignancy or high MIB-1 labeling indices. Close follow-up and aggressive treatments of these tumors are warranted.

Crush Cytology of a Primary Intraspinal Rhabdoid Papillary Meningioma: A Case Report

“…Combined types of meningiomas frequently coexist in low-grade meningiomas, but are not uncommon in high-grade meningiomas, like rhabdoid or papillary types. No previous case of primary intraspinal occurrence has been reported in the previously reported rhabdoid papillary meningiomas; all 15 cases of rhabdoid papillary meningiomas occurred in the brain except for the present case, and 12 of them showed recurrence, intraspinal and/or intracerebral [4,5,6,7,8,9,10,11,12]. Six cases, including the present one, showed leptomeningeal seeding.…”

“…In contrast to the relatively common phenomenon of combined types of meningioma of low grade, combined rhabdoid and papillary meningioma resembling ependymoma was first described by Perry et al [2] and Kepes et al [3]. To date, 14 cases of rhabdoid papillary meningiomas have been reported, and all of the previously reported cases occurred in the brain meninges [4,5,6,7,8,9,10,11,12]. To the best of our knowledge, no case of primary intraspinal rhabdoid papillary meningioma has been reported in the literature.…”

Papillary meningioma in the dog: A clinicopathological case series study

“…Only in 1975 Ludwin et al first attempted to define PM as a distinct clinicopathologic entity based on its relativity high incidence in children, aggressive behavior, and high rate of morbidity and mortality (Ludwin et al, 1975). Today, according to the 2007 World Health Organization (WHO) human classification system (Perry et al, 2007), PM is a rare subtype accounting for 1.0-2.5% of all meningiomas (Avninder et al, 2007;Russel and Rubinstein, 1989) characterized by the presence of a perivascular pseudopapillary pattern extending to majority of the tumor and frequently increasing in following recurrence (Wu et al, 2011). Despite its histological pattern not conforming to anaplastic meningioma, PM is included into WHO grade III tumor group due to the tendency to display brain invasion, local recurrence and distant metastases (Perry et al, 2007).…”

“…This classification recognizes 15 different histological variants most of which are considered as grade I. Except for anaplastic form of meningiomas, included into grade III, four meningioma variants are considered innately more aggressive, due to their high rate of recurrence and mortality (Perry et al, 2007;Wu et al, 2011). Human papillary meningioma (PM) is characterized by perivascular pseudopapillary pattern either entirely or more commonly in combination with other histological pattern of meningioma (Perry et al, 2007).…”

“…Meningiomas are common tumors arising from the arachnoidal cap cells of the meninges (Wu et al, 2011). They represent approximately 30-46% of all intracranial central nervous system (CNS) tumors in dogs (Keyerleber et al, 2013;Snyder et al, 2006).…”