“Rhabdoid” Wilms’ Tumor. An Ultrastructural Study

Fung, Christopher H. K.; Gonzales-Crussi, Frank; Yonan, Theodore N.; Martinez, Noly

doi:10.1016/s0022-5347(17)54067-7

Cited by 11 publications

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“…It occurs primarily in the infant and newborn, 60% to 70% of all RTs of the kidney [1,3,11,16,[49][50][51]. Rhabdoid tumor of the kidney is the second most common with metastases to the skin or other sites in addition to the primary kidney tumor [1,3,9,33,37,49,55,56].…”

Section: Discussionmentioning

confidence: 99%

Fetal and neonatal rhabdoid tumor

Isaacs

2010

Journal of Pediatric Surgery

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Section: Discussionmentioning

confidence: 99%

Fetal and neonatal rhabdoid tumor

Isaacs

2010

Journal of Pediatric Surgery

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“…The survival rate for RTK is dismal which is less than 10% when diagnosed before age 2 years [8,42]. However, isolated case reports of neonates surviving after a combined treatment approach consisting of nephrectomy, chemotherapy, and radiation therapy are reported [45]. Outcomes for RTK in this study were as follows: stage I, 0 of 3; stage II, 1 (14%) of 7; stage III, 0 of 1; stage IV, 1 (10%) of 10; stage V, 0 of 1; compared with the data from the NWTS including older children: stage I, 33%; stage II, 47%; stage III, 22%; and stage IV, 8% [37] (Table 6).…”

Section: Discussionmentioning

confidence: 99%

Fetal and neonatal renal tumors

Isaacs

2008

Journal of Pediatric Surgery

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“…Since subsequent ultrastructural 2,3 and immunohistochemical 4 investigations of these cells did not show any evidence of rhabdomyoblastic differentiation, the descriptive term rhabdoid was introduced to designate these neoplasms, 2 thus emphasizing their resemblance to rhabdomyosarcomas. Following these publications, numerous reports of tumors having rhabdoid cells and occurring in a wide variety of extrarenal locations appeared in the literature which resulted in considerable debate regarding the nomenclature and histogenesis of these tumors.…”

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Mesothelioma with rhabdoid features: an ultrastructural and immunohistochemical study of 10 cases

Ordóñez

2006

Modern Pathology

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Mesotheliomas with rhabdoid morphology are rare and only two individual case reports have been documented in the literature. This author reports a series of 10 cases of mesotheliomas with rhabdoid features, nine of which originated in the pleura and one in the peritoneum. Eight of the patients were men and two were women. Six patients had a history of asbestos exposure. Histologically, seven of the mesotheliomas were epithelioid, two sarcomatoid, and one biphasic. The proportion of the rhabdoid cells seen in these cases constituted 15-75% of the individual tumors. Cytoplasmic staining in the rhabdoid cells was seen for pan-keratin and vimentin in all 10 cases, for keratin 7 in eight of eight, for calretinin in nine of 10, and for keratin 5/6 in seven of nine. Nuclear positivity for WT1 was observed in the rhabdoid cells of four of seven cases and membranous reactivity for mesothelin in four of six, and for podoplanin in two of six. Only one case showed desmin positivity in sparse cells in the nonrhabdoid component of the tumor. All of the cases were negative for CEA, MOC-31, TAG-72, CD15, CD34, bcl2, muscle-specific actin, and TTF-1. Ultrastructural studies revealed paranuclear collections of intermediate filaments, but no evidence of rhabdomyoblastic differentiation was seen. The mean survival of five of the six patients for whom this information was available was 3.8 months. The remaining patient had a survival time of 1 year. It is important for pathologists to be aware that mesotheliomas can present rhabdoid features, not only because they can be confused with other malignancies that can exhibit a similar morphology, but also because of their apparently unusually aggressive behavior. The value of immunohistochemistry and electron microscopy in the differential diagnosis of these tumors is discussed.

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“Rhabdoid” Wilms’ Tumor. An Ultrastructural Study

Cited by 11 publications

References 0 publications

Fetal and neonatal rhabdoid tumor

Fetal and neonatal rhabdoid tumor

Fetal and neonatal renal tumors

Mesothelioma with rhabdoid features: an ultrastructural and immunohistochemical study of 10 cases

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