Rhabdomyolysis and Acute Kidney Injury as Leading COVID-19 Presentation in an Adolescent

Tram, Nathalie; Chiodini, Benedetta; Montesinos, Isabel; Vicinanza, Alfredo; Beretta-Piccoli, Xavier; Gubbelmans, Natacha; Demey, Milena; Genis, Nathalie; Tilmanne, Anne; Smeesters, Pierre; Ismaïli, Khalid

doi:10.1097/inf.0000000000002853

Cited by 17 publications

(16 citation statements)

References 9 publications

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“… 49 Rhabdomyolysis and AKI with no fever or respiratory symptoms were reported as the presenting symptoms of an adolescent affected with COVID‐19. 50 …”

Section: Methodsmentioning

confidence: 99%

The overall impact of COVID‐19 on healthcare during the pandemic: A multidisciplinary point of view

Sabetkish

Rahmani

2021

Health Science Reports

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Background and Aims The Coronavirus disease 2019 (COVID‐19) pandemic globally changed the priorities of medical and surgical procedures. It has caused many healthcare systems to stop performing their routine screenings. Altering medical clinics to COVID‐19 referral centers, lockdowns, and the public fear to refer to medical centers caused a significant reduction in the referral rate; especially in the elderly. This short review article highlights the transform in clinical practice during the post‐COVID era and the need for future medical revolutions. Methods A comprehensive literature search was separately performed by both authors. The articles published between 2019 and August 2021 were included in this study and selected according to a quality appraisal method. Results We have summarized the possible corresponding changes in the diagnosis and treatment of all fields of medical care including internal medicine, surgical, and minor subcategories after the COVID‐19 pandemic. We have also discussed the potential impacts of the pandemic on all these different categories and subcategories of medicine, including the outpatient setting and clinical work. We do believe that the lack of routine check‐ups has led to an increase in the stage of disease in patients with a previously diagnosed problem. On the other hand, the dramatic change in the lifestyle of the population including restricted mobility and increased consumption of unhealthy food has caused metabolic syndrome and other new diseases that have not been diagnosed and properly managed. Conclusion Our findings revealed the urgent need for public health awareness. It indicated the need to carry out both psychological and screening approaches in the post‐COVID era to not miss patients with a chronic disease and new cases who were undiagnosed during the COVID pandemic.

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“… 49 Rhabdomyolysis and AKI with no fever or respiratory symptoms were reported as the presenting symptoms of an adolescent affected with COVID‐19. 50 …”

Section: Methodsmentioning

confidence: 99%

The overall impact of COVID‐19 on healthcare during the pandemic: A multidisciplinary point of view

Sabetkish

Rahmani

2021

Health Science Reports

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“…This suggests COVID-19 to be the likely etiology as the other causes have been ruled out. There are cases that reported COVID-19 associated rhabdomyolysis in pediatric and young adults (18-35 years) (Table 1) [20][21][22][23][24][25]. The mechanism by which COVID-19 causes muscle damage is uncertain, but various mechanisms have been described for another viral myositis, including direct invasion of muscle tissue by the virus [9,13], immunologic processes induced by the virus that results in muscle damage, and the cytokine storm released in response to viral infection [9,26].…”

Section: Discussionmentioning

confidence: 99%

Asymptomatic Rhabdomyolysis in a Young Adult With COVID-19

Farouji¹,

Hellou²,

Peretz³

2021

Cureus

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The novel coronavirus disease 2019 (COVID-19) is an ongoing pandemic. Although COVID-19 is frequently associated with respiratory symptoms and complications, multiple extrapulmonary manifestations have been identified since the beginning of the pandemic. Rhabdomyolysis has been described in the literature as one of the extrapulmonary manifestations of COVID-19. Herein, we describe a 21-year-old male patient who presented with cough and fever secondary to COVID-19 confirmed by positive reverse-transcription polymerase chain reaction (RT-PCR) for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The patient presented with an extremely elevated creatinine kinase (CK) of 53,886 U/L (normal 10-170) without any classical symptoms of rhabdomyolysis or deterioration in his kidney function. He was successfully managed with aggressive intravenous fluids. The aim of reporting this case is to highlight the importance of including total CK in the initial evaluation of COVID-19 patients.

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“…Rhabdomyolysis is an important cause of AKI among COVID 19 patients. [ 13 14 15 16 ] Actual incidence of AKI due to COVID 19 associated rhabdomyolysis is largely unknown. In a study from China, kidney abnormalities were studied among 26 autopsies of patient.…”

Section: Discussionmentioning

confidence: 99%

COVID-19 in CKD patients: Report from India

Pawar¹,

Tiwari²,

Gupta³

et al. 2021

Indian J Nephrol

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Background: COVID-19 is a novel acute infection that is mainly manifested as acute respiratory disease. Information on coronavirus disease-2019 (COVID-19) in CKD patients who are not on dialysis is very limited. We are reporting a single-center observational study on the effect of COVID-19 in CKD patients. Methods: A single-center retrospective study with consecutive patients who had eGFR <60 mL/min/1.73 m 2 (CKD-EPI) admitted with COVID-19, from April to July 2020 were included. Result: A total of 30 patients were included in the study. Patients of CKD stage 5, 4 and 3 were 50%, 13.3%, and 36.6%, respectively. The mortality rate was 53.3%. Category wise, 9 were in mild; 3 in moderate, and 18 were in the severe COVID category. Twenty-five patients (83.3%) developed acute on CKD. Twenty patients (67%) required renal replacement therapy (RRT). The prognosis of patients who required RRT was poor. High LDH and IL-6 were significantly associated with mortality. Lymphopenia, present in 50% of cases was associated with fatal outcome. There was a 100% survival rate in mild to moderate cases and 11% in severe cases. Conclusion: Mortality among hospitalized CKD patients is high.

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Rhabdomyolysis and Acute Kidney Injury as Leading COVID-19 Presentation in an Adolescent

Cited by 17 publications

References 9 publications

The overall impact of COVID‐19 on healthcare during the pandemic: A multidisciplinary point of view

The overall impact of COVID‐19 on healthcare during the pandemic: A multidisciplinary point of view

Asymptomatic Rhabdomyolysis in a Young Adult With COVID-19

COVID-19 in CKD patients: Report from India

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