Rhabdomyolysis associated with the nutritional supplement Hydroxycut

Abstract

An 18-year-old Caucasian man with no significant medical history developed rhabdomyolysis possibly associated with the ingestion of Hydroxycut in addition to his increased exercise regimen.

Dietary Supplements

“…The particular AE related to DS noted by the physicians in our study presented a pattem: exertional rhabdomyolysis, hyperthermia/ heat illness, aeute renal failure, arrhythmias, and syneopal events. Similar AE appears in the literature as ease reports (10,13,19,21,22,24,29,36). Coupled with the AE reports were consistent pattems of speeific DS use.…”

Self-Administration of Exercise and Dietary Supplements in Deployed British Military Personnel During Operation TELIC 13

“…There was relatively high use of chromium polynicotinate-based products ("Hydroxycut"). Hydroxycut, a supplement that alleges it can enhance weight-loss, has previously been associated with rhabdomyolysis including a case in the US military [9][10][11]. It has also been implicated in seizures12 and hepatic failure [13], including the case of a soldier in Iraq [14].…”

Acute Paraspinal Compartment Syndrome Related to Use of Proprietary Weight Loss Product, by a Patient with Sodium Channelopathy

“…Muscle bulk may increase by 20% after exertion [13] and direct myonecrosis can complicate overexertion [14,15]. Rhabdomyolysis can also be induced by a range of prescription medications, illicit drugs and dietary supplements [16][17][18], and while a reliable risk estimate of rhabdomyolysis with ephedrine containing weight loss products has not been established, concern based largely on case reports of a range of side effects have led to a call for regulation of these products [19]. Previous case reports of acute exertional compartment syndrome report use of isotretinoin and of supplements containing creatine, cocaine, testosterone and as in this case ephedrine [6,8].…”