Rhabdomyolysis due to primary hyperaldosteronism

Martínez, José Joaquín Alfaro; Oliveira, Cristina Lamas; Meneses, A. Lomas; Rodríguez, Silvia Aznar; Corrales, Pedro Pinés; López, Almudena López; Romero, Francisco Botella

doi:10.1016/s1575-0922(09)72715-9

Cited by 15 publications

(6 citation statements)

References 17 publications

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“…Hypokalemia induced rhabdomyolysis was reported as a complication of hyperaldesteronism or pseudoaldesteronism 23 , laxatives 24 , liquorice ingestion 25 and many other etiologies. Endocrine abnormalities such as hyperaldosteronism 26,27 , Addison's disease 28 , hypothyroidism 29 , hyperthyroidism 30 , diabetic ketoacidosis 20,31 , non-ketotic hyperosmolar state 32 have been reported occasionally to cause rhabdomyolysis.…”

Section: Electrolyte and Endocrine Abnormalitiesmentioning

confidence: 99%

Rhabdomyolysis. The role of diagnostic and prognostic factors

Keltz

Khan

Mann

2019

Muscle Ligaments and Tendons J

106

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Rhabdomyolysis, literally meaning the breakdown of muscle tissue, is a common syndrome with many causes, acquired ones such as exertion, trauma, infections, temperature extremes, drugs, toxins, electrolyte and endocrine abnormalities, and congenital ones such as myopathies and connective tissue disorders. All results in a common pathophysiologic pathway which ends with the dispersing of muscle tissue content into the circulation. Rhabdomyolysis has characteristic clinical, laboratory and radiologic features, but does require a high index of suspicion so that the diagnosis would not be missed. The sensitivity and specificity of the various characteristics, as well as clinical guidelines, are discussed in this paper. The syndrome may present with several complications, e.g. arrhythmias, electrolyte abnormalities, acute renal injury, acidosis, volume depletion, compartment syndrome and disseminated intravascular coagulation. The prognosis is highly variable and depends on the underlying etiologies and complications, but is in general considered as good. The milestone of treatment is vigorous fluid resuscitation. Treatment options, in practice and in research, are discussed in the following pages.

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Section: Electrolyte and Endocrine Abnormalitiesmentioning

confidence: 99%

Rhabdomyolysis. The role of diagnostic and prognostic factors

Keltz

Khan

Mann

2019

Muscle Ligaments and Tendons J

106

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“…Der Aldosteron-ReninQuotient (ARQ) lag deutlich oberhalb der Norm (Tabelle 1) [22] lassen sich schon bei der Erstbeschreibung der Erkrankung durch Jerome W. Conn finden [23]. Die vom Hausarzt gemessene CK-Erhöhung ist wahrscheinlich durch eine hypokaliämische Rhabdomyolyse verursacht worden [9,14]. In diesem Fall wäre das Kalium tatsächlich niedrig gewesen und der Kaliumwert von 4,8 mmol/l falsch hoch gemessen worden.…”

Section: Diagnose: Häufige Ursachen Einerunclassified

Paresen, Myalgien und massive CK-Erhöhung: eine schwere neurologische Erkrankung?

Steinfurt

Müller²,

Seidel

et al. 2010

Med Klin

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“…We also noted ongoing rhabdomyolysis in this patient with CPK increasing up to 21,000 U/L, which improved with adequate hydration. This may be attributed due to the failure of synthesis of glycogen and inadequate vasodilation of arterioles and capillaries of exercising muscles in the presence of hypokalemia in an otherwise ambulatory patient before he presented to us [ 19 ].…”

Section: Discussionmentioning

confidence: 99%