Rhabdomyolysis in Acute Primary Adrenal Insufficiency Complicated by Severe Hyponatraemia

Lau, Su Yin; Yong, Tuck Yean

doi:10.2169/internalmedicine.51.7879

Cited by 15 publications

(11 citation statements)

References 17 publications

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“…Rhabdomyolysis can occur as a result of electrolyte abnormalities (hypokalemia, hypophosphatemia, hyponatremia, and hypernatremia) in the setting of endocrine diseases such as diabetes 60–63 , thyroid dysfunction 64, 65 , primary hyperaldosteronism 66 , primary adrenal insufficiency 67 , central diabetes insipidus 68 , postpartum hypernatremia 69 , and pituitary dysfunction 70 . Cases of rhabdomyolysis have also been attributed to electrolyte disturbances (primarily hypokalemia and hyponatremia) in the setting of laxative and diuretic misuse/abuse 71–73 .…”

Section: Acquired Causes Of Rhabdomyolysismentioning

confidence: 99%

Diagnostic evaluation of rhabdomyolysis

2015

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Rhabdomyolysis is characterized by severe acute muscle injury resulting in muscle pain, weakness, and/or swelling with release of myofiber contents into the bloodstream. Symptoms develop over hours to days following an inciting factor and may be associated with dark pigmentation of the urine. Serum creatine kinase and urine myoglobin levels are markedly elevated. The clinical examination, history, laboratory studies, muscle biopsy, and genetic testing are useful tools for diagnosis of rhabdomyolysis, and they can help differentiate acquired from inherited causes of rhabdomyolysis. Acquired causes include substance abuse, medication or toxic exposures, electrolyte abnormalities, endocrine disturbance, and autoimmune myopathies. Inherited predisposition to rhabdomyolysis can occur with disorders of glycogen metabolism, fatty acid beta-oxidation, and mitochondrial oxidative phosphorylation. Less common inherited causes of rhabdomyolysis include structural myopathies, channelopathies, and sickle cell disease. This review focuses on the differentiation of acquired and inherited causes of rhabdomyolysis and proposes a practical diagnostic algorithm.

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Section: Acquired Causes Of Rhabdomyolysismentioning

confidence: 99%

Diagnostic evaluation of rhabdomyolysis

2015

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“…In some cases, mild hypercalcemia (rarely) and uremia (55% of cases) are observed. 3,9,12,18 Diagnosis can generally be achieved by measuring baseline levels of cortisol between 8:00 and 9:00 AM. The diagnosis of AI is confirmed if the value is less than 5 μg/mL (some authors consider < 3 μg/mL).…”

Section: Methodsmentioning

confidence: 99%

Conduct protocol in emergency: Acute adrenal insufficiency

Fares

Santos

2016

Rev. Assoc. Med. Bras.

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“…Convulsions because of hyponatraemia can also cause muscle damage and a subsequent rise in CK. Lau and Yong describe a patient with acute primary adrenal insufficiency and severe hyponatraemia complicated by RM and AKD [110].…”

Section: Adrenal Insufficiencymentioning

confidence: 99%

Non-traumatic and non-drug-induced rhabdomyolysis

Kolovou

Cokkinos

Bilianou

et al. 2019

Arch Med Sci Atheroscler Dis

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Rhabdomyolysis (RM), a fortunately rare disease of the striated muscle cells, is a complication of non-traumatic (congenital (glycogen storage disease, discrete mitochondrial myopathies and various muscular dystrophies) or acquired (alcoholic myopathy, systemic diseases, arterial occlusion, viral illness or bacterial sepsis)) and traumatic conditions. Additionally, RM can occur in some individuals under specific circumstances such as toxic substance use and illicit drug abuse. Lipid-lowering drugs in particular are capable of causing RM. This comprehensive review will focus on non-traumatic and nondrug-induced RM. Moreover, the pathology of RM, its clinical manifestation and biochemical effects, and finally its management will be discussed.

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Rhabdomyolysis in Acute Primary Adrenal Insufficiency Complicated by Severe Hyponatraemia

Cited by 15 publications

References 17 publications

Diagnostic evaluation of rhabdomyolysis

Diagnostic evaluation of rhabdomyolysis

Conduct protocol in emergency: Acute adrenal insufficiency

Non-traumatic and non-drug-induced rhabdomyolysis

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