Rhabdomyolysis in Hepatitis A

Abstract

Hepatitis A is usually a mild self-limiting infection of liver. Rhabdomyolysis complicating acute nonfulminant hepatitis A is exceedingly rare. We present here a case report of 19-year-old young male with hepatitis A, who developed rhabdomyolysis with acute renal failure. He underwent dialysis and made a complete recovery with normalization of laboratory tests.

Beyond the liver: unveiling rhabdomyolysis as a rare complication of hepatitis A

“…These include but are not limited to tissue hypoxia, bacterial infiltration into muscle tissue, diminished activity of oxidative and glycolytic enzymes, triggering of lysosomal enzyme cascades, and involvement of endotoxin mediated pathways [ 8 ] . In our case, presentation with bilateral lower extremity weakness, muscle pain, non-bloody diarrhoea, erythematous rash, and pertinent abnormal labs pointed towards rhabdomyolysis as a complication of acute hepatitis A infection [ 9 ] . Rhabdomyolysis in the context of acute hepatitis A is an uncommon complication.…”

“…It is important to note that rhabdomyolysis alone can also lead to elevated liver enzymes; however, the positive hepatitis A IgM along with clinical symptoms consistent with hepatitis A and lack of other typical risk factors for rhabdomyolysis supports the likelihood of rhabdomyolysis as a complication of hepatitis A [ 10 ] . Additionally, acute renal failure secondary to rhabdomyolysis can complicate the clinical course, emphasizing the need for prompt recognition and management to prevent severe complications [ 9 ] .…”

“…the likelihood of rhabdomyolysis as a complication of hepatitis A [10] . Additionally, acute renal failure secondary to rhabdomyolysis can complicate the clinical course, emphasizing the need for prompt recognition and management to prevent severe complications [9] . The treatment approach for rhabdomyolysis secondary to acute hepatitis A involves aggressive fluid resuscitation to prevent kidney damage from myoglobinuria.…”

“…Rhabdomyolysis is an exceedingly rare complication of HAV infection that is not well documented in the literature [5,6] .…”

“…Various complications of HAV infection are fulminant liver failure, acute kidney injury, autoimmune haemolytic anaemia, aplastic anaemia, acute pancreatitis, mononeuritis, reactive arthritis, glomerulonephritis, cryoglobulinemia, Guillain–Barre syndrome, and pleural or pericardial effusion [ 4 ] . Rhabdomyolysis is an exceedingly rare complication of HAV infection that is not well documented in the literature [ 5 , 6 ] . The classic clinical manifestations of rhabdomyolysis are myalgia, weakness, and myoglobinuria which presents as tea-coloured urine [ 7 ] .…”