Rhabdomyolysis in Para-Phenylenediamine Intoxication

Fj, Baud; Bismuth, C; Galliot, M; Garnier, R.; Peralma, A.

doi:10.1016/s0140-6736(83)90539-1

Cited by 13 publications

(5 citation statements)

References 3 publications

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“…Since, other cases were reported [3][4]. In France, cases have been reported by F. Baud [7] in a Moroccan family.…”

Section: Discussionmentioning

confidence: 99%

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Epidemiological profile of acute intoxication with paraphenylenediamine (Occidental TAKAWT) in the Oriental region in Morocco: 1996-2007

Rebgui¹

2013

IOSR-JESTFT

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In order to reduce morbidity and mortality resulting from poisoning by para-phenylenediamine (PPD), we described the epidemiological and clinical characteristics associated with such poisoning and determined the risk factors. For this purpose, we conducted a retrospective descriptive study of 102 cases reported by the Moroccan Poison Control and Drug Monitoring Center between 1996 and 2007 in the Oriental region. Based on the results, and with a sex ratio (men/women) of 0.9, the average age of the intoxicated population was 17.3 ± 15.6 years. The most affected group age was of adults whom age is between 20 to 74 (40.2 %). The most encountered cases were voluntary poisonings, with 91.8 %. Suicidal attempts had accounted for 99% of voluntary intoxication. The majority of the intoxicated had presented gastrointestinal disorders. The evolution was favorable for 87 cases (85.3 %) and 15 cases had lost their lives; the lethality was of 14.7 %. Following the analysis of the relative risk, age (less than 15 years / over 15 years) and origin of the intoxicated (Urban / Rural) have been the main factors that influenced the prognosis. The relative risk being, respectively, of 2.25 (95% CI: 1, 28-3, 95) and 3, 72 (CI 95%: 1. 70 -8.13).

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“…Since, other cases were reported [3][4]. In France, cases have been reported by F. Baud [7] in a Moroccan family.…”

Section: Discussionmentioning

confidence: 99%

“…The age group most at risk was that of adults whom age is between 20 and 74 (40.2%), followed by baby walkers [1-4 years old] (24.5%) and children [5][6][7][8][9][10][11][12][13][14] (15.4%). The average age of the affected people is 17.3 ± 15.6 years.…”

Section: A Epidemiological An Clinical Profile Of Poisonings In the mentioning

confidence: 99%

Epidemiological profile of acute intoxication with paraphenylenediamine (Occidental TAKAWT) in the Oriental region in Morocco: 1996-2007

Rebgui¹

2013

IOSR-JESTFT

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“…In investigations of hair dye preparations, 110 g of a commercially available dye preparation was mixed with ring-labelled 14 C-p-phenylenediamine and 2.5 g 6% hydrogen peroxide and rubbed into the dry hair of 5 male test persons for 5 to 8 minutes; 20 minutes later, the hair was washed and shaved off. Urine was collected from the test persons during 6 days and the radioactivity measured.…”

Section: Pharmacokineticsmentioning

confidence: 99%

p‐Phenylenediamine [MAK Value Documentation, 1993]

2012

The MAK‐Collection for Occupational Health and Safety

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Published in the series Occupational Toxicants , Vol. 6 (1993) The article contains sections titled: Toxic Effects and Modes of Action Pharmacokinetics Effects in Man Acute toxicity Effects on skin and mucous membranes Allergenic effects Chronic toxicity Effects on Animals Acute toxicity Effects on skin and mucous membranes Allergenic effects Chronic Toxicity Reproductive and Developmental Toxicity Genotoxicity Carcinogenicity Manifesto (MAK value, classification)

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“…4 Exposure to these chemicals may lead to intravascular haemolysis, haemoglobinuria, methaemoglobinaemia and rhabdomyolysis all of which are implicated in the associated acute kidney injury. 4,6,8 PPD poisoning is generally characterized by the triad of angioneurotic oedema, rhabdomyolysis and acute tubular necrosis. Diagnosis requires a high degree of suspicion and a comprehensive history.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Attempted suicide by ingestion of hair dye containing p-phenylenediamine: a case report

2017

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Para-phenylenediamine is widely used as a chemical in hair dyes and in combination with henna. This dye is used to paint the body for decorative reasons, to speed the processing time of henna and to intensify the results. Para-phenylenediamine is widely used in the Middle East, North Africa and India. Several reports have been published of the fatal ingestion of hair dye containing para-phenylenediamine. Here, we describe the case of a 14-year-old girl who ingested the compound but whose prompt treatment prevented her death. Ingestion of para-phenylenediamine produces a typical triad of angioneurotic oedema, rhabdomyolysis and acute tubular necrosis. Awareness of signs of these associated conditions in our patient, together with a comprehensive history, facilitated appropriate treatment to be instituted. We document the steps we took to enable her complete physical recovery.

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Rhabdomyolysis in Para-Phenylenediamine Intoxication

Cited by 13 publications

References 3 publications

Epidemiological profile of acute intoxication with paraphenylenediamine (Occidental TAKAWT) in the Oriental region in Morocco: 1996-2007

Epidemiological profile of acute intoxication with paraphenylenediamine (Occidental TAKAWT) in the Oriental region in Morocco: 1996-2007

p‐Phenylenediamine [MAK Value Documentation, 1993]

Attempted suicide by ingestion of hair dye containing p-phenylenediamine: a case report

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