Rhabdomyolysis induced by excessive coffee drinking

Wf, Chiang; Mt, Liao; Cj, Cheng; Sh, Lin

doi:10.1177/0960327113510536

Cited by 19 publications

(8 citation statements)

References 20 publications

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“…The clinical features of caffeine intoxication vary but have been reported to include cardiovascular symptoms (hypertension, hypotension, tachycardia, bradycardia, atrioventricular block, supraventricular tachycardia (SVT), ventricular tachycardia or ventricular fibrillation, myocardial ischemia, myocardial infarction, and cardiac arrest), gastrointestinal symptoms (nausea, vomiting, severe recurrent vomiting, abdominal pain, diarrhea), psychological/neurological symptoms (delusions, hallucinations anxiety, agitation, excitation, seizures, headache, cerebral edema, coma), metabolic symptoms (hypokalemia, hyponatremia, hypocalcemia, metabolic acidosis, respiratory alkalosis, hyperglycemia, fever), musculoskeletal symptoms (weakness, rigidity, tremor, rhabdomyolysis), pulmonary symptoms (hyperventilation, respiratory failure), tinnitus, dizziness, diuresis, and death [ 21 , [26] , [27] , [28] , [29] , [33] , [34] , [35] ]. Renal failure and questionable hepatic injury (i.e., based only upon modest transaminase elevation which is known to occur in cases of rhabdomyolysis) secondary to rhabdomyolysis have also been reported [ 36 , 37 ].…”

Section: Clinical Featuresmentioning

confidence: 99%

“…In cases of metabolic acidosis and hypokalemia, sodium bicarbonate and potassium chloride have been used, respectively [ [36] , [37] , [38] ]. In the case of rhabdomyolysis, intravenous fluid resuscitation is most important but sodium bicarbonate might also be helpful [ 32 , [36] , [37] , [38] ].…”

Section: Management/treatment Strategiesmentioning

confidence: 99%

“…Several other case reports have been published concerning caffeinated energy drinks where the patient similarly consumed several drinks and ultimately experienced either myocardial infarction (i.e., ST-Elevation Myocardial Infarction or STEMI) or arrhythmia [ [191] , [192] , [193] ]. In another case a 44 year old woman developed nausea, vomiting, chest tightness, muscle twitching, palpitations and rhabdomyolysis six hours after ingesting approximately 1000 mL of coffee (estimated caffeine intake was 565 mg or 14 mg/kg body weight) [ 37 ]. In this particular case however, toxicity may have been related to her lower bodyweight (i.e., around 40 kg), allowing for high plasma concentrations to be reached.…”

Section: A Case Reconstructionmentioning

confidence: 99%

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The clinical toxicology of caffeine: A review and case study

Willson¹

2018

Toxicology Reports

199

138

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Caffeine is a widely recognized psychostimulant compound with a long history of consumption by humans. While it has received a significant amount of attention there is still much to be learned with respect to its toxicology in humans, especially in cases of overdose. A review of the history of consumption and the clinical toxicology of caffeine including clinical features, pharmacokinetics, toxicokinetics, a thorough examination of mechanism of action and management/treatment strategies are undertaken. While higher (i.e., several grams) quantities of caffeine are known to cause toxicity and potentially lethality, cases of mainly younger individuals who have experienced severe side effects and death despite consuming doses not otherwise known to cause such harm is troubling and deserves further study. An attempted case reconstruction is performed in an effort to shed light on this issue with a focus on the pharmacokinetics and pharmacodynamics of caffeine.

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Section: Clinical Featuresmentioning

confidence: 99%

Section: Management/treatment Strategiesmentioning

confidence: 99%

Section: A Case Reconstructionmentioning

confidence: 99%

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The clinical toxicology of caffeine: A review and case study

Willson¹

2018

Toxicology Reports

199

138

View full text Add to dashboard Cite

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“…Studies have shown that excessive caffeine intake from energy drinks can cause arrhythmias, hypertension, dehydration, sleeplessness, nervousness, and in rare instances, rhabdomyolysis. In our literature search, only one case report of rhabdomyolysis caused by caffeinated beverages was found (3). Additional complications can arise depending on the individual's overall health status (e.g., cardiac conditions, diabetes and anxiety disorders) and other drugs or medications that patients may be taking (e.g., medications for attention deficit disorder).…”

Section: Discussionmentioning

confidence: 99%

A remarkable case of rhabdomyolysis associated with ingestion of energy drink ‘neon volt’

Iyer

Yelisetti

Miriyala

et al. 2016

Journal of Community Hospital Internal Medicine Perspectives

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Rhabdomyolysis is defined as a syndrome characterized by muscle necrosis and the release of intracellular muscle constituents into the circulation. We present a case of a 35-year-old male who exercised for 2 h after ingesting energy drink and subsequently presented with rhabdomyolysis. After excluding common and uncommon causes of rhabdomyolysis, we reached the conclusion that the likely cause was the ingestion of energy drink ‘NEON VOLT’ in a setting of mild dehydration. Increasing physical activity and intense exercise is becoming a trend in many countries, due to its many health-related benefits such as prevention of obesity. This renewed focus toward optimal fitness has spawned many supplements that aid in improvement of the performance, muscle growth, and recovery. Energy drinks predominantly contain caffeine that is often combined with other supplements to form what manufacturers have termed an ‘energy blend’. Studies have shown that excessive caffeine intake from energy drinks can cause arrhythmias, hypertension, dehydration, sleeplessness, nervousness, and in rare instances, rhabdomyolysis. As per Drug Abuse Warning Network report, there is a sharp increase in the number of emergency department visits involving energy drinks from 1,128 visits in 2005 to 16,053 and 13,114 visits in 2008 and 2009, respectively. Due to emergence of energy drink abuse as a national health problem, Food and Drug Administration has launched a dietary supplement adverse event reporting system for surveillance of any adverse events linked to these agents.

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“…Individual with preexisting anxiety disorders are more sensitive to the effect of Caffeine [43] . In rare cases, rhabdomyosis has been reported attributable to Caffeine [44,45] . It causes reduction in cerebral perfusion, that may sustain for 90 min of administration can thus reduce effectiveness of several drugs and can cause exacerbation in psychiatric illnesses in patient on maintenance therapy [46,47] .…”

Section: Effect Of Dte On Haloperidol-induced Catalepsymentioning

confidence: 99%

Pharmacological Screening of Decaffeinated Tea Extract to Explore Potential Adjuvant Therapy in Parkinsonism.

Salve¹,

Kasture²,

Kokare³

2017

JCPR

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Parkinson's disease (PD) is a consequence of specific progressive neurodegeneration of substantia nigra pars compacta dopaminergic neuron resulting depletion in Dopamine (DA). Ldopa is first line DA replacement therapy. Caffeine and Antimuscarinic agents are effective adjuvant in PD management. Caffeine is given to counteract the adverse effects of anticholinergics. Caffeine is considered as a very safe psychostimulant. Contrary, higher doses of Caffeine associated with tachycardia, nausea and vomiting. Anticholinergics at therapeutic doses produce amnesia and cognitive impairment, particularly intense in elderly with preexisting neurodegenerative disease. Little is known about association between caffeine use, toxicity and dependence and risk of common psychiatric and substance use disorder. In present study, Decaffeinated Tea Extract (DTE) has been screened for antimuscarnic and anticataleptic activity. The results indicate that DTE significantly inhibited Ach-induced contractions and Haloperidolinduced catalepsy. The effects are comparable to Atropine & Caffeine. As per our study findings, decaffeinated tea is an effective option as an adjuvant as compared to Caffeine and Atropine.

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Rhabdomyolysis induced by excessive coffee drinking

Cited by 19 publications

References 20 publications

The clinical toxicology of caffeine: A review and case study

The clinical toxicology of caffeine: A review and case study

A remarkable case of rhabdomyolysis associated with ingestion of energy drink ‘neon volt’

Pharmacological Screening of Decaffeinated Tea Extract to Explore Potential Adjuvant Therapy in Parkinsonism.

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