Rhabdomyonecrosis experimentally induced in Wistar rats by Africanized bee venom

Azevedo-Marques, M.M.; Ferreira, Dirceu B.; Costa, R. S.

doi:10.1016/0041-0101(92)90875-6

Cited by 24 publications

(20 citation statements)

References 9 publications

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“…The amines are histamine, serotine and acetylcholine; the peptide are mastoparan and hornet kinin; and the enzymes are phospholipase A, hyalulonidase, and protease (20)(21)(22). Mastoparan, phospholipase A, and hyalulonidase can each damage cell membranes directly (21,23,24) and, as a result, rhabdomyolysis could result (24,25). In addition, acute renal failure or hepatic injury may occur due to the direct nephrotoxicity or hepatotoxicity of the venom (26).…”

Section: Discussionmentioning

confidence: 99%

Cutaneous hemorrhage or necrosis findings afterVespa mandarinia(wasp) stings may predict the occurrence of multiple organ injury: A case report and review of literature

Yanagawa

Morita

Sugiura

et al. 2007

Clinical Toxicology

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Section: Discussionmentioning

confidence: 99%

Cutaneous hemorrhage or necrosis findings afterVespa mandarinia(wasp) stings may predict the occurrence of multiple organ injury: A case report and review of literature

Yanagawa

Morita

Sugiura

et al. 2007

Clinical Toxicology

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“…The presence of different molecules in the venom, including phospholipase A2, hyaluronidase, melittin, apamine [37][38][39][40] , and, most recently, a serine protease-like protein studied by Lima et al 41 , may contribute to skin necrosis at the sting site. Such necrosis has frequently occurred and has been reported by most studies in Brazil [33][34][35][36][37][38][39][40][41][42][43][44][45] . The presence of rhabdomyolysis characterized by fiber eosinophilia, vacuolization, and absence of nuclei can be seen in Figure 1B.…”

Section: Anatomopathological Examinationmentioning

confidence: 99%

“…Other intramuscular cell enzymes like LDH and AST increased as well. Experimental bee venom-induced rhabdomyolysis with enzyme elevations was previously described by Azevedo-Marques and colleagues 44 . The main factor responsible for rhabdomyolysis in bee venom is most likely melittin 48 .…”

Section: Anatomopathological Examinationmentioning

confidence: 99%

“…Accordingly, Figure 1C shows necrotic cardiocytes demonstrated by fiber anucleation, eosinophilia, and lumpy cytoplasmic material, associated with mild interstitial mononuclear infiltrate. The venom provokes rhabdomyolitic activity in both experimental animals and humans 44 . In severe cases, there are areas of myocardial necrosis similar to microinfarctions.…”

Section: Anatomopathological Examinationmentioning

confidence: 99%

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Africanized honeybee stings: how to treat them

Almeida

Olivo

Mendes

et al. 2011

Rev. Soc. Bras. Med. Trop.

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Introduction:In 1956, Africanized honeybees (AHB) migrated from Brazil to other regions of the Western Hemisphere, including South, Central, and North America, except for Canada. Despite being productive, they are highly aggressive and cause fatal accidents. This study aimed to evaluate patients at the Clinical Hospital of Botucatu Medical School (HC-FMB) and to propose treatment guidelines. Methods: From 2005 to 2006, the clinical and laboratorial aspects of 11 patients (7 male and 4 female) and the anatomopathological aspects of one patient who had died in 2003 were analyzed. Results: The age of the surviving patients varied from 5 to 87 years, with a mean of 42.5 years. The majority of accidents occurred in the afternoon, and the number of stings ranged from 20 to 500. The principal signs and symptoms were pain and local inflammatory signs, nausea, tachycardia, and vomiting. Biochemical findings presented increased levels of creatine phosphokinase, lactate dehydrogenase, and aspartate/alanine aminotransferase. An 11-year-old male patient died upon entering the attic of a two-storey building where he was attacked by a swarm, receiving more than 1,000 stings. He was sent to HC-FMB where he was treated, but he died 24h later. Observed at the autopsy were erythematous-purpuric skin lesions besides necrosis at the sting locations, rhabdomyolysis, focal myocardial necrosis, tubular hydropic degeneration and focal tubular acute necrosis of the kidneys, myoglobinuria, and centrolobular necrosis in the liver. Conclusions: Accidents caused by multiple AHB stings always constitute a medical emergency. As there is no specific antivenom, we have developed guidelines, including first aid, drugs, and the proper removal of stingers.

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“…ABV was collected as described previously 1 and inoculated iv at a dose of 0.4 µl/100 g body weight, diluted 1:500 in saline. The solution was stored at 4 o C and used within 24 h of venom collection.…”

Section: Methodsmentioning

confidence: 99%

Cardiovascular profile after intravenous injection of Africanized bee venom in awake rats

Guimarães

Costa

Machado

et al. 2004

Rev. Inst. Med. trop. S. Paulo

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SUMMARYThe manifestations caused by Africanized bee stings depend on the sensitivity of the victim and the toxicity of the venom. Previous studies in our laboratory have demonstrated cardiac changes and acute tubular necrosis (ATN) in the kidney of rats inoculated with Africanized bee venom (ABV). The aim of the present study was to evaluate the changes in mean arterial pressure (MAP) and heart rate (HR) over a period of 24 h after intravenous injection of ABV in awake rats. A significant reduction in basal HR as well as in basal MAP occurred immediately after ABV injection in the experimental animals. HR was back to basal level 2 min after ABV injection and remained normal during the time course of the experiment, while MAP returned to basal level 10 min later and remained at this level for the next 5 h. However, MAP presented again a significant reduction by the 7 th and 8 th h and returned to the basal level by the 24 th h. The fall in MAP may contribute to the pathogenesis of ATN observed. The fall in MAP probably is due to several factors, in addition to the cardiac changes already demonstrated, it is possible that the components of the venom themselves or even substances released in the organism play some role in vascular beds.

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Rhabdomyonecrosis experimentally induced in Wistar rats by Africanized bee venom

Cited by 24 publications

References 9 publications

Cutaneous hemorrhage or necrosis findings afterVespa mandarinia(wasp) stings may predict the occurrence of multiple organ injury: A case report and review of literature

Cutaneous hemorrhage or necrosis findings afterVespa mandarinia(wasp) stings may predict the occurrence of multiple organ injury: A case report and review of literature

Africanized honeybee stings: how to treat them

Cardiovascular profile after intravenous injection of Africanized bee venom in awake rats

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