Rhabdomyosarcoma of the Heart

Abstract

A case of rhabdomyosarcoma of the heart diagnosed through biopsy material and confirmed by autopsy is reported because of the few recorded instances and the unusually diffuse nature of t h e neoplasm. The h e a r t with tumor weighed 1450 g. There was a single metastasis t o a mediastinal lymph node. PPROXIMATELY 200 SARCOMAS PRIMARILY A involving the myocardium have been re-rorded, 31 of which were rhabdomyosarco-mas.' Because of the few recorded instances and the unusually diffuse nature of the neo-plasm we encountered, the following additional case is being reported.

Transgenic model of cardiac rhabdomyosarcoma formation

“…Immunohistochemistry revealed the cardiac tumors to stain positive for smooth muscle a-actin, troponin C, desmin, and, in a fraction of cells, Myo D1, which met the criteria for cardiac rhabdomyosarcoma. 1,24,34,35 In the present model the integrity of the expressed transgene was confirmed by means of immunohistochemical staining from an antibody recognizing the COOH-terminal end of TAg. In addition, transgene expression was found to be in line with the promoter function.…”

“…Most data are based on case reports or small retrospective series. [24][25][26][27][28][29] However, reports on the pathogenesis of cardiac rhabdomyosarcoma formation have been rather descriptive, and systematic pathogenetic studies are lacking.…”

Surgical treatment of cardiac tumors - an overview and presentation of interesting cases

“…Rhabdomyosarcoma account for about 5% of cardiac sarcoma and derived from the striated muscle. Usually, rhabdomyosarcoma are large and grow into the myocardium but may also protrude into a ventricular cavity [42,44]. Complete excision is rarely possible.…”

Akute Herzinsuffizienz

“…Auch der Beitrag von Vujin et al [8] über einen Herztumor gehört in die Kategorie seltener Ursachen einer akuten kardialen Dekompensation. Die Kasuistik von Götze et al [11] zeigt, dass eine angeborene AV-Fistel erst nach Jahrzehnten symptomatisch werden und zu einer Herzinsuffizienz führen kann.…”