Rhabdomyosarcoma of the maxillary sinus: Review of the literature and report of a case

Grieman, Rick B.; Katsikeris, Nick; Symington, J.M.

doi:10.1016/0278-2391(88)90456-9

Cited by 8 publications

(3 citation statements)

References 28 publications

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“…The alveolar type appears as loosely arranged, malignant cells with septae that are reminiscent of the alveoli of the lung 1. Since these lesions exhibit morphological features in common with other spindle cell neoplasms further immunohistochemical analysis is necessary for definitive diagnosis1,9 RMS is characteristically positive for desmin, smooth muscle actin, and myoglobin 1,13,14…”

Section: Discussionmentioning

confidence: 99%

A Case of Alveolar Rhabdomyosarcoma of the Ethmoid Sinus Invading the Orbit in an Adult

Moon

Kwon

Lee

2006

Korean J Ophthalmol

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PurposeA case study and literature review of alveolar rhabdomyosarcoma (RMS) in an adult.MethodsA 48-year-old male patient presented at our clinic complaining of proptosis that had persisted for 2 weeks in his left eye. A computed tomography (CT) scan revealed a destructive soft-tissue mass in the left ethmoid sinus with invasion of the left orbit and compression of the medial rectus muscle. Endoscopic intranasal biopsy revealed alveolar RMS. Conservative debulking and orbital wall decompression were performed.ResultsImmunohistochemical testing was positive for desmin, S-100, and smooth muscle actin (SMA), supporting the diagnosis of RMS. Since ipsilateral cervical and spinal metastasis was detected, systemic treatment was administered simultaneously.ConclusionsAlthough rarely found in adults, RMS should be considered in the differential diagnosis of orbital tumors. Immunohistochemical analysis plays an important role in the definitive diagnosis of RMS.

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Section: Discussionmentioning

confidence: 99%

A Case of Alveolar Rhabdomyosarcoma of the Ethmoid Sinus Invading the Orbit in an Adult

Moon

Kwon

Lee

2006

Korean J Ophthalmol

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“…4 Parameningeal RMSs have been rarely reported in adults, particularly young adults. [5][6][7][8][9][10][11][12][13][14][15][16][17][18][19] We report 13 adult patients, ranging in age from 18 to 86 years, with RMS involving parameningeal sites, predominantly the sinonasal cavity.…”

Section: Embryonal and Alveolar Rhabdomyosarcoma Of Parameningeal Sites In Adults: A Report Of 13 Casesmentioning

confidence: 99%

Embryonal and Alveolar Rhabdomyosarcoma of Parameningeal Sites in Adults: A Report of 13 Cases

et al. 2008

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This study reports 13 adult parameningeal rhabdomyosarcomas. Ages ranged from 18 to 86 years. Nine lesions were alveolar, 3 were embryonal, and 1 could not be further classified. All cases were positive for desmin and/or myogenin and 1 tumor was strongly positive for cytokeratin. PAX3-FKHR or PAX7-FKHR fusion transcripts or FKHR breaks were identified in 5 cases confirming a diagnosis of alveolar rhabdomyosarcoma. Three cases were negative supporting a diagnosis of embryonal rhabdomyosarcoma. A total of 10 patients were treated with chemotherapy and radiation. Three patients are alive with no disease, 3 are alive with disease, 3 died of disease, and 4 patients are lost to follow-up. Adult sinonasal rhabdomyosarcoma is uncommon and should be considered in the differential of sinonasal neoplasms. Disease can occur in the elderly. Desmin and myogenin can aid in the diagnosis but cytokeratin reactivity can be seen and care must be taken not to diagnose carcinoma.

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“…fusion of the PAX3 on chromosome2 or the PAX7 gene on chromosome 1 with the FKHR gene or chromosome 13.The resulting fusion gene results ir the production of a protein product, which is believed to activate the myogenic transcription cascade contribute to oncogenic pathways 8 .The fusion produc can be detected by reverse transcriptase polymerase chain reaction (RT-PCR) and is diagnostic of ARMS 9 Histological diagnosis of RMS has improved markedly with the current use of immunohistochemistry, electror microscopy and molecular genetic studies'.We repor a case of Embryonal Rhabdomyosarcoma in an adul Hypopharynx treated with a combined modality treatment of chemotherapy , radiotherapy & finally surgical excision as per the European Internationa Society of Paediatric Oncology (SlOP).She respondec to treatment & 5 yrs later she is still alive.…”

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confidence: 99%

Embryonal Rhabdomyosarcoma of Adult Hypopharynx

Hasan

Mamun

Chowdhury

et al. 2012

J Shaheed Suhrawardy Med Coll

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Rhabdomyosarcoma of the maxillary sinus: Review of the literature and report of a case

Cited by 8 publications

References 28 publications

A Case of Alveolar Rhabdomyosarcoma of the Ethmoid Sinus Invading the Orbit in an Adult

A Case of Alveolar Rhabdomyosarcoma of the Ethmoid Sinus Invading the Orbit in an Adult

Embryonal and Alveolar Rhabdomyosarcoma of Parameningeal Sites in Adults: A Report of 13 Cases

Embryonal Rhabdomyosarcoma of Adult Hypopharynx

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