2024
DOI: 10.1515/med-2024-1116
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Rhein promotes skin wound healing by activating the PI3K/AKT signaling pathway

Dong Yang,
Wei Li,
Ping Xiang
et al.

Abstract: Rhein is a natural anthraquinone substance extracted from Rheum palmatum L. This study aimed to evaluate Rhein’s protective effects against skin wound by in vivo and in vitro models and investigate whether its protective mechanism regulated the PI3K/AKT signaling pathway. The skin wound mice model was established and then treated with Rhein for 10 days. Hematoxylin and eosin staining and Masson’s trichrome staining were applied to assess histological changes and collagen maturity in the mice skin wound tissues… Show more

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