Rheo-dissolution: A new platform for the simultaneous measurement of rheology and drug release

Senjoti, Faria Gias; Ghori, Muhammad Usman; Diryak, Ramadan; Conway, Barbara R.; Morris, Gordon A.; Smith, Alan M.

doi:10.1016/j.carbpol.2019.115541

Cited by 13 publications

(8 citation statements)

References 32 publications

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“…[8][9][10] Rheological and texture profile analyses were selected as the main subject of this article taking into consideration the well-known importance of viscosity and viscoelastic properties of the carrier for drug release. 11,12 A detailed investigation of the rheology and texture of the system might be useful for analyzing the properties important for the therapeutic efficacy of the studied systems. For example, in the diffusion-governed dosage forms, the drug is released in a prolonged manner when the carrier viscosity is higher.…”

Section: Introductionmentioning

confidence: 99%

Rheological and textural analysis as tools for investigation of drug-polymer and polymer–polymer interactions on the example of low-acyl gellan gum and mesalazine

et al. 2022

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Purpose. In the performed study, the rheological and textural parameters of gellan-based hydrogels were investigated and their dependence on three factors was taken into consideration: ( i) The presence of the model drug, ( ii) The presence and type of the ionic crosslinking agent, and ( iii) the composition of the polymer network. The objective was to compare two analytical methods, regarded as complementary, and define to what extent the obtained results correlate with each other. Methods. The hydrogels contained low-acyl gellan gum or its mixtures with hydroxyethyl cellulose or κ-carrageenan. CaCl2 and MgCl2 were used as gelling agents. Mesalazine was used as a model drug. The rheological analysis included oscillatory stress and frequency sweeping. The texture profile analysis was performed to calculate texture parameters. Results. Placebo gels without the addition of gelling agents had the weakest structure. The drug had the strongest ability to increase the stiffness of the polymer network. The weakest structure revealed the placebo samples without the addition of gelling agents. Texture analysis revealed no significant influence of the drug on the strength of the gels, while rheological measurements indicated clear differences. Conclusions. It can be concluded that in the case of some parameters methods correlate, that is, the effect related to gelling ions. However, the rheological analysis seems to be more precise and sensitive to some changes in the mechanical properties of the gels.

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Section: Introductionmentioning

confidence: 99%

Rheological and textural analysis as tools for investigation of drug-polymer and polymer–polymer interactions on the example of low-acyl gellan gum and mesalazine

et al. 2022

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“…However, the obvious challenge is their manufacturing process as fabricating smaller batches of medicines, especially designed for individual patients, can be problematic, time-consuming and costly. However, the recent emergence of 3D printing technologies has given pharmaceutical scientists a way forward to develop personalised medicines and devices [24][25][26][27][28][29]. The current project, therefore, is aimed at addressing the limitations as mentioned above by developing additively manufacturing fast-dissolving captopril tablets.…”

Section: Introductionmentioning

confidence: 99%

Personalised 3D Printed Fast-Dissolving Tablets for Managing Hypertensive Crisis: In-Vitro/In-Vivo Studies

et al. 2020

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Hypertensive crisis (HC) is an emergency health condition which requires an effective management strategy. Over the years, various researchers have developed captopril based fast-dissolving formulations to manage HC; however, primarily, the question of personalisation remains unaddressed. Moreover, commercially these formulations are available as in fixed-dose combinations or strengths, so the titration of dose according to patient’s prerequisite is challenging to achieve. The recent emergence of 3D printing technologies has given pharmaceutical scientists a way forward to develop personalised medicines keeping in view patients individual needs. The current project, therefore, is aimed at addressing the limitations as mentioned above by developing fast-dissolving captopril tablets using 3D printing approach. Captopril unloaded (F1) and loaded (F2-F4) filaments were successfully produced with an acceptable drug loading and mechanical properties. Various captopril formulations (F2–F4) were successfully printed using fused deposition modelling technique. The results revealed that the formulations (F2 and F3) containing superdisintegrant had a faster extent of dissolution and in-vivo findings were endorsing these results. The present study has successfully exhibited the utilisation of additive manufacturing approach to mend the gap of personalisation and manufacturing fast-dissolving captopril 3D printed tablets. The procedure adopted in the present study may be used for the development of fused deposition modelling (FDM) based fast-dissolving 3D printed tablets.

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“…Interestingly, the design enables the monitoring of hydrogel degradation by replacing the CaCl 2 filter with one containing a calcium chelator [79], while it has been utilized to study the effect of the physiological fluids on the mechanical response of cross-linking hydrogels [80]. Based on these advantages, a rheo-dissolution cell has been developed controlling both the in situ gelation and the drug release profile of gelling systems [81]. In 2020, Besiri et al [82] introduced an advanced setup for mixing the reactants on the rheometer during the external gelation, one resembling a batch reactor operation.…”

Section: Advanced Rheometric Setupsmentioning

confidence: 99%

Experimental Advances in the Real-Time Recording of Cross-Linking Alginate In Situ Gelation: A Review

et al. 2023

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Alginate-based hydrogels are promising smart materials widely employed in the food, bioengineering, and energy sectors. The development and optimization of their production require a thorough knowledge of gelation. In recent years, advanced experimental procedures have been developed for real-time cross-linking alginate reaction monitoring. Novel methods, such as customized rheometric setups, enable the recording of mechanical properties and morphological changes during hydrogel formation. These innovative techniques provide important insights into the gelation stages, the reaction rate, the diffusion of cross-linker to polymer chains, and the homogeneity of the gelling structures. Based on real-time experimental data, kinetic models are developed to enhance comprehension of the reaction mechanism and, eventually, to predict the gelation progress. The aim is to enable better control of the characterization of both the complex gelation and the propagated structures. This review aspires to present a comprehensive overview and evaluation of the breakthrough innovations of the real-time in situ recording of cross-linking alginate hydrogels and bead formation. A detailed analysis of the pioneering experimental developments provides a deep comprehension of the alginate gelation, including the parameters controlling the reaction.

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Rheo-dissolution: A new platform for the simultaneous measurement of rheology and drug release

Cited by 13 publications

References 32 publications

Rheological and textural analysis as tools for investigation of drug-polymer and polymer–polymer interactions on the example of low-acyl gellan gum and mesalazine

Rheological and textural analysis as tools for investigation of drug-polymer and polymer–polymer interactions on the example of low-acyl gellan gum and mesalazine

Personalised 3D Printed Fast-Dissolving Tablets for Managing Hypertensive Crisis: In-Vitro/In-Vivo Studies

Experimental Advances in the Real-Time Recording of Cross-Linking Alginate In Situ Gelation: A Review

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