Rheological and textural properties of microemulsion-based polymer gels with indomethacin

Abstract

In this paper, we present novel microemulsion (ME)-based semisolid polymer gels designed for topical administration of poorly water soluble non-steroidal anti-inflammatory drugs. Indomethacin (IND) was used as a model compound. The ME consisted of castor oil, water, Tween®80 as a surfactant and ethanol as cosurfactant. To obtain the desired consistency of the formulations Carbopol®960 was applied as a thickening agent. The aim of the study was to analyze in detail the mechanical properties of the obtained systems, with special attention paid to the features crucial for topical application. The rheological and textural experiments performed for samples with and without the incorporated drug clearly indicate that flow characteristics, viscoelastic properties and texture profiles were affected by the presence of IND. Novel semisolid formulations with IND described for the first time in this paper can be considered as an alternative for commercially available conventional topical dosage forms.

Synthesis and study of organo‐modified silica based hydrogels: Rheological properties and drug release kinetics

“…The acceleration of polycondensation, aggregation of the amino modified silica particles and an increase in their size was facilitated by an increase in the pH of the medium at the stage of adding the organosilane 51 ; The OA loading result in a decrease in the yield stress of the hydrogels. The same effect was found for microemulsion‐based polymer gels with indomethacin 52 . The introduction of the drug in the hydrogels makes their structure weaker because the interaction of OA with the silica matrixes is weaker that SiOSi bonds.…”

“…The same effect was found for microemulsion-based polymer gels with indomethacin. 52 The introduction of the drug in the hydrogels makes their structure weaker because the interaction of OA with the silica matrixes is weaker that Si O Si bonds. The higher drug loading, the greater disorder it introduces into the silica network and structure of the hydrogel composite;…”

Lipid-Based Nanocarriers for Neurological Disorders: A Review of the State-of-the-Art and Therapeutic Success to Date

“…ME are suitable for drug delivery due to their ease of preparation [167], unstable API protection [168], enhanced solubility of lipophilic API [169], controlled release of API [162], improved bioavailability via high absorption rates and enhanced penetration of biological membranes [170], improved shelf-life [171], and reduced intra-and interindividual variability in the pharmacokinetics of an API [172]. The solubility of hydrophilic and lipophilic API may be improved by solubilization within globules and additional sites at the interfacial film [169,171]. Hence, in an ME system, drug loading is permitted at saturation solubility and thermodynamic activity is enhanced, resulting in the drug favorably partitioning toward and permeating through biological membranes [173].…”

Extraction of male steroids and progesterone from water by vegetable oil gels and their determination by partial filling capillary micellar electrokinetic chromatography

“…Microemulsions are frequently transformed into complex semi‐solid systems with the use of thickening agents, such as polymers , low‐molecular‐mass organic compounds , and/or inorganic compounds . Commonly, gels made of surfactant, co‐surfactant, water, and oil can be formed to enhance products that are useful in pharmaceutical industry due to their feasibility as drug carriers .…”