rheological assessment of mucolytic activity induced by seaprose

Braga, Pier Carlo; Rampoldi, C.; Ornaghi, Ana Paula; G, Caminiti; Beghi, G.; Allegra, L.

doi:10.1016/s1043-6618(05)80053-2

Cited by 3 publications

(2 citation statements)

References 5 publications

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“…Frog palates can be obtained in large quantities, the frog palate is a robust tissue giving reproducible results, and the experimental technique is well established, with many transport studies having been performed with this model. [24][25][26][27][28][29] In contrast, human turbinates are in limited supply and the tissue is more fragile and sensitive to sub-optimal conditions than the frog palate. However, this human model also gives reproducible results, which alludes to the possibility of identifying subtle differences between the effects of various compounds on MTR.…”

Section: Discussionmentioning

confidence: 99%

Chitosan as a Nasal Delivery System: The Effect of Chitosan Solutions on in Vitro and in Vivo Mucociliary Transport Rates in Human Turbinates and Volunteers

Aspden¹,

Mason²,

Jones³

et al. 1997

Journal of Pharmaceutical Sciences

238

105

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In these studies, we examined the effect on mucociliary transport rates (MTR) of various 0.25% (w/v) chitosan solutions applied to human nasal tissue both ex vivo and in vivo. In the first study a range of chitosans with different molecular weights were applied to freshly amputated human nasal turbinates, and their effect on MTR was recorded. The transient inhibitory effect on turbinate MTR that was found for most of the chitosan preparations showed a marked dependence on the volume of chitosan solution applied and the molecular weight of the chitosan tested. The higher the molecular weight of the chitosan and the more chitosan applied, the longer the original MTR was depressed. A small scale human trial, investigating the effect of chitosan glutamate, on saccharin clearance times, was also undertaken. The study showed that a once daily application of a 0.25% solution of the chitosan for 7 days had no effect on either saccharin clearance times or nasal histology as examined by light microscopy.

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Section: Discussionmentioning

confidence: 99%

Chitosan as a Nasal Delivery System: The Effect of Chitosan Solutions on in Vitro and in Vivo Mucociliary Transport Rates in Human Turbinates and Volunteers

Aspden¹,

Mason²,

Jones³

et al. 1997

Journal of Pharmaceutical Sciences

238

105

View full text Add to dashboard Cite

show abstract

“… 109 Some proteolytic enzymes such as trypsin, chymotrypsin, streptodornase, streptokinase, streptopeptidase, sfericase and seaprose have been shown to reduce mucus viscosity and improve mucociliary clearance. 110–111 2…”

Section: Effects Of Drugs On Mucus Rheologymentioning

confidence: 99%