Rheological behavior probed by vibrating microcantilevers

Belmiloud, Naser; Dufour, Isabelle; Colin, Annie; Nicu, Liviu

doi:10.1063/1.2837181

Cited by 50 publications

(46 citation statements)

References 5 publications

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“…Different methods for fluid property determination have been developed using the transverse bending mode which, as noted earlier, is more influenced by the fluid properties than other modes [30]. The first of these permits the determination of both the mass density and viscosity of the fluid at the resonant frequency of the microcantilever in the fluid [29]; the second enables one to extract the same properties over a frequency range that includes the in-fluid resonant frequency [31]; two other methods are based on the same principle, but with the assumption that the fluid's mass density is known. These latter methods allow for the determination of the real and imaginary parts of the fluid's shear modulus, which characterize both the elasticity and viscosity of the fluid [32].…”

Section: Use Of Hydrodynamic Force Study For the Measurement Of Fluidmentioning

confidence: 99%

Effect of hydrodynamic force on microcantilever vibrations: Applications to liquid-phase chemical sensing

Dufour

Lemaire

Caillard

et al. 2014

Sensors and Actuators B: Chemical

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Abstract:At the microscale, cantilever vibrations depend not only on the microstructure's properties and geometry but also on the properties of the surrounding medium. In fact, when a microcantilever vibrates in a fluid, the fluid offers resistance to the motion of the beam. The study of the influence of the hydrodynamic force on the microcantilever's vibrational spectrum can be used to either (1) optimize the use of microcantilevers for chemical detection in liquid media or (2) extract the mechanical properties of the fluid. The classical method for application (1) in gas is to operate the microcantilever in the dynamic transverse bending mode for chemical detection. However, the performance of microcantilevers excited in this standard out-of-plane dynamic mode drastically decreases in viscous liquid media. When immersed in liquids, in order to limit the decrease of both the resonant frequency and the quality factor, and improve sensitivity in sensing applications, alternative vibration modes that primarily shear the fluid (rather than involving motion normal to the fluid/beam interface) have been studied and tested: these include inplane vibration modes (lateral bending mode and elongation mode). For application (2), the classical method to measure the rheological properties of fluids is to use a rheometer. However, such systems require sampling (no insitu measurements) and a relatively large sample volume (a few milliliters). Moreover, the frequency range is limited to low frequencies (less than 200Hz). To overcome the limitations of this classical method, an alternative method based on the use of silicon microcantilevers is presented. The method, which is based on the use of analytical equations for the hydrodynamic force, permits the measurement of the complex shear modulus of viscoelastic fluids over a wide frequency range.

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Section: Use Of Hydrodynamic Force Study For the Measurement Of Fluidmentioning

confidence: 99%

Effect of hydrodynamic force on microcantilever vibrations: Applications to liquid-phase chemical sensing

Dufour

Lemaire

Caillard

et al. 2014

Sensors and Actuators B: Chemical

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“…Viscosity measurements of engine oils, silicone oils and glycerol solutions with the use of millimeter scale cantilevers with large sample volumes (around 3 ml) have been demonstrated [13][14][15]. Although there are other studies introducing measurements with microcantilevers [16][17][18][19][20][21][22], the working range or sensitivity is not suitable for the blood plasma viscosity measurement due to various limitations imposed by operating cantilevers in liquids.…”

Section: Introductionmentioning

confidence: 99%

Microcantilever based disposable viscosity sensor for serum and blood plasma measurements

Çakmak

Elbüken

Ermek

et al. 2013

Methods

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a b s t r a c tThis paper proposes a novel method for measuring blood plasma and serum viscosity with a microcantilever-based MEMS sensor. MEMS cantilevers are made of electroplated nickel and actuated remotely with magnetic field using an electro-coil. Real-time monitoring of cantilever resonant frequency is performed remotely using diffraction gratings fabricated at the tip of the dynamic cantilevers. Only few nanometer cantilever deflection is sufficient due to interferometric sensitivity of the readout. The resonant frequency of the cantilever is tracked with a phase lock loop (PLL) control circuit. The viscosities of liquid samples are obtained through the measurement of the cantilever's frequency change with respect to a reference measurement taken within a liquid of known viscosity. We performed measurements with glycerol solutions at different temperatures and validated the repeatability of the system by comparing with a reference commercial viscometer. Experimental results are compared with the theoretical predictions based on Sader's theory and agreed reasonably well. Afterwards viscosities of different Fetal Bovine Serum and Bovine Serum Albumin mixtures are measured both at 23°C and 37°C, body temperature. Finally the viscosities of human blood plasma samples taken from healthy donors are measured. The proposed method is capable of measuring viscosities from 0.86 cP to 3.02 cP, which covers human blood plasma viscosity range, with a resolution better than 0.04 cP. The sample volume requirement is less than 150 ll and can be reduced significantly with optimized cartridge design. Both the actuation and sensing are carried out remotely, which allows for disposable sensor cartridges.

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“…The performance of the microcantilever degrades by considerable damping. Because when the cantilever is immersed in a fluid, it suffers resistance being offered by fluid [34]. Consequently, both resonant frequency and the Quality factor of the beam decreases drastically when the operating medium i.e.…”

Section: B Selection Of Mode Of Vibrationmentioning

confidence: 99%

Microcantilever: An Efficient Tool for Biosensing Applications

Sharma¹,

Tripathi²

2017

IJISA

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Abstract-Most of the biosensing applications involving analysis and detection of a particular specimen demands fast, easy to use, less expensive, highly reliable and sensitive method for the recognition of biomolecules. The reason behind this increasing demand is that most of the available laboratory equipment require large space, are highly expensive and have other preconditions. Most of the viscometers available for measuring the rheological properties of blood require cleaning after each use which can be challenging due to the capillary geometry. The substitute to this is microcantilever that has emerged as an ideal candidate for biosensing applications. Microcantilever is capable of being used in air, vacuum or liquid medium. This paper consists of seven sections in which working principle of a cantilever, different modes of vibration, their comparative analysis, analytical equations of hydrodynamic equations exerted by the fluid on the cantilever and their impact on the resonant frequency and quality factor, applications of microcantilever in liquid medium specifically in biomedical field are discussed.

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Rheological behavior probed by vibrating microcantilevers

Cited by 50 publications

References 5 publications

Effect of hydrodynamic force on microcantilever vibrations: Applications to liquid-phase chemical sensing

Effect of hydrodynamic force on microcantilever vibrations: Applications to liquid-phase chemical sensing

Microcantilever based disposable viscosity sensor for serum and blood plasma measurements

Microcantilever: An Efficient Tool for Biosensing Applications

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