Rheological characterization of bioadhesive, antimicrobial, semisolids designed for the treatment of periodontal diseases: Transient and dynamic viscoelastic and continuous shear analysis

Examination of the flow rheological and textural properties of polymer gels composed of poly(methylvinylether‐co‐maleic anhydride) and poly(vinylpyrrolidone): Rheological and mathematical interpretation of textural parameters

“…2,19 The plate diameter was selected according to the consistency of the sample, and accordingly a 6-cm diameter plate was used for gels containing 15% PMVE/MA and either 0 or 3% PVP, whereas a 4-cm-diameter plate geometry was used for samples containing 15% PMVE/MA and either 6 or 9% PVP. Samples were applied to the lower stationary plate of the rheometer and allowed to equilibrate for 30 min before analysis.…”

“…13 As a result, several studies have examined the mechanical and rheological properties of gel systems using traditional rheological methods, e.g., flow rheometry, oscillatory rheometry, and creep analysis. For example, the rheological properties of poly-(acrylic acid) gels have been characterized in several studies, [14][15][16][17] whereas the rheological properties of cellulose ethers and of polymer gel networks containing cellulose ethers have been described by Doelker 18 and Jones et al [2][3][4]19 A method that has received recent attention for the characterization of pharmaceutical systems is texture profile analysis (TPA). 2,20 In this technique, an analytical probe is twice depressed into the sample under examination, allowing a defined recovery period between successive compressions.…”

Rheological and mucoadhesive characterization of polymeric systems composed of poly(methylvinylether-co-maleic anhydride) and poly(vinylpyrrolidone), designed as platforms for topical drug delivery

“…Instruments, Surrey, UK) with 6-cm diameter stainless steel parallel plates and gap size of 1000 mm, as previously reported. 1,15 Samples were applied to the lower stationary plate of the rheometer and allowed to equilibrate for 30 min prior to analysis. The linear viscoelastic region was determined by torque sweep from 0.1-100 Pa at frequencies of 0.01 and 1.0 Hz (at 20 AE 0.18C), and was identified as the region where stress was directly proportional to strain and the storage modulus (G 0 ) remained constant.…”

“…This difficulty arises from the relatively hostile environment within the oral cavity, for example, chewing and swallowing processes, dilution of the local concentration of therapeutic agent by salivary production, and removal of the drug delivery system from the site of application due to the shedding of mucus. 14,15 Recently, the suitability of bioadhesive gel and semisolid systems for the treatment of disorders of the oral cavity, for example, periodontal disease, has been examined, 1,5,15,16 and their clinical success illustrated. 2,6 However, while the clinical utility of such systems has been proven, their rheologic properties may prohibit their successful application to more diffuse areas of disease within the oral cavity, for example, for the treatment of lichen planus.…”

“…Therefore, the aims of this study were to (uniquely) examine the rheological (flow and oscillatory) and textural (mechanical) properties of gels composed of PMVE/MA and PVP, properties that have been shown to be determinants of clinical performance. 1,2,5,6,15 Furthermore, in light of the importance of mucoadhesion to the performance of drug delivery systems designed for application to the oral cavity, 2,6,7 the mucoadhesive properties of these systems were also determined. Finally, based on the information derived from this study, the suitability of these mixed polymer systems as platforms for drug delivery to the oral cavity may be ascertained.…”