Rheological characterization of new thermosensitive hydrogels formed by chitosan, glycerophosphate, and phosphorylated β-cyclodextrin

Barragán, Carlos Alberto Ramírez; Balleza, Emma Rebeca Macías; García-Uriostegui, Lorena; Ortega, Jesús Ángel Andrade; Toríz, Guillermo; Delgado, Ezequiel

doi:10.1016/j.carbpol.2018.08.076

Cited by 30 publications

(17 citation statements)

References 68 publications

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“…Polymer blends provide a simple approach to combine the advantages of different polymers, for example adhesiveness and environmental responsiveness (Barbosa et al, 2017;Borghi-Pangoni et al, 2015;Bruschi et al, 2007;Jones et al, 2009;Liu, Lin, Li, & Liu, 2005). Thermoresponsive gelling systems have been widely studied over the years for drug delivery, mainly due to their ease of application, spreadability and retention at the application site (de Francisco et al, 2019;Ramírez Barragán et al, 2018). Moreover, where these thermoresponsive materials are composed of nanostructured micelles derived from amphiphilic block copolymers they may improve solubilization, stabilization and control of drug delivery (Jindal & Mehta, 2015).…”

Section: Introductionmentioning

confidence: 99%

Thermoresponsive systems composed of poloxamer 407 and HPMC or NaCMC: mechanical, rheological and sol-gel transition analysis

Silva

Cook

Bruschi

2020

Carbohydrate Polymers

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Poloxamer 407 (polox407) is widely studied as thermogelling polymer, transitioning to a gel state when warmed. Polox407 has the limitation that it forms weak hydrogels, with rapid dissolution in excess solvent. This study reports the development of new binary polymeric systems composed of polox407 and hydroxypropyl methylcellulose (HPMC) or sodium carboxymethylcellulose (NaCMC) with an aim to improve the rheological and mechanical properties of the hydrogel. The interaction between polox407 and cellulose derivatives was studied, and their interaction with biological surfaces predicted. The carbohydrates affected the mechanical and rheological behavior of polox407 in different ways, dependent on polymer type, concentration, and temperature.Tsol/gel and rheological interaction parameters were useful to select the most suitable formulations for topical or local application, ensuring in situ gelation and the formation of a strong gel. Most of the binary systems exhibited plastic behavior, with thixotropic and viscoelastic properties. Appropriate formulations were identified for local application, such as 17.

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Section: Introductionmentioning

confidence: 99%

Thermoresponsive systems composed of poloxamer 407 and HPMC or NaCMC: mechanical, rheological and sol-gel transition analysis

Silva

Cook

Bruschi

2020

Carbohydrate Polymers

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“…The hydrogel preparation was fabricated by the previously reported methods. 41 - 43 In this examination, the 3 components of the CD@β-GP hydrogels as below. The C solution was synthesized by the dissolving of C (150 mg) in 7 mL acetic acid solution under RT.…”

Section: Methodsmentioning

confidence: 99%

Synergistic Fabrication of Dose–Response Chitosan/Dextran/β-Glycerophosphate Injectable Hydrogel as Cell Delivery Carrier for Cardiac Healing After Acute Myocardial Infarction

Chen

Liu

Hua³

et al. 2020

Dose-Response

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The human mesenchymal stem cells (hMSCs) therapy offering an encouraging the new methods to establish the conveying on the chitosan (C)/dextran (D)/β-glycerophosphate (β-GP) loaded with hMSCs to enhance the acute myocardial infarctions. The synthesized hMSCs-CD@β-GP system displayed the ratio of determination modules, size of the pore, absorbency, and the swellings ratio in the assortment of the 65 ka, 149 ± 39.8 µm, 92.2%, 42 ± 1.38, and 29 ± 1.9, respectively. The fabricated hMSCs-CD@β-GP was highly stable and physicochemical investigated and confirmed the suitability of the materials for cardiac regeneration applications. The in vitro examinations of the injectable hydrogels with hMSCs-CD@β-GP have recognized that the improved survival rate of the cells, increased the pro-inflammatory expressions factors, pro-angiogenic factors analysis confirmed the promising results of the ejection of fractions, fibrosis area, vessel density with decreased infractions size, with suggesting that the remarkable improvement of the heart regenerative function after myocardial infarctions. The new synergistic approach of the injectable hydrogels with hMSCs could able appropriate for the effective treatment of cardiac therapies after acute myocardial infarctions.

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“…This route can be used for any age category, but especially in children and the elderly or unconscious people [ 3 , 4 , 103 ], without the need for qualified staff [ 9 , 61 ]. Nasal administration has other advantages: It is not painful [ 60 ], it does not require sterilization [ 9 ], it is non-invasive [ 61 ], parenteral administration can be avoided (e.g., for insulin) [ 3 , 4 , 103 ], and it increases the patient’s adhesion to treatment [ 9 ]. Enzymatic and acidic degradation in the gastrointestinal tract is prevented by the nasal administration of drugs (e.g., insulin) [ 106 ] and the effect of systemic dilution is minimized [ 104 ].…”

Section: The Nasal Routementioning

confidence: 99%

“…The development of thermo-sensitive hydrogels, which are administered in the nasal route and which pass from the soil phase at room temperature to the gel phase when they reach body temperature is constantly advancing [ 3 , 103 , 116 ]. A hydrogel based on chitosan and β-glycerophosphate is a thermo-sensitive one [ 3 , 118 ]. This type of hydrogel is used for the nasal administration of doxepine, bypassing BBB [ 119 ].…”

Section: Chitosan-based Formulations For Intranasal Administrationmentioning

confidence: 99%

“…Chitosan, the second most common natural polysaccharide [ 1 , 2 , 3 , 4 ] and the only polycationic polysaccharide extracted from bio sources, is obtained from chitin by N -deacetylation [ 5 ]. The sources of chitin are crustaceans (crabs and shrimps), cephalopods [ 2 ], cuttlefish [ 5 ], insects (spiders, beetles, and ants) [ 3 , 6 ], fungi [ 1 , 3 , 4 ], spores [ 6 ], protozoa [ 2 ], yeasts [ 7 ], and algae [ 2 , 6 ]. Chitosan is a polymeric polysaccharide [ 5 ] ( Figure 1 ) with a linear structure [ 8 ], is unbranched [ 9 ] and flexible [ 5 ], and has a high nitrogen content [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

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New Opportunity to Formulate Intranasal Vaccines and Drug Delivery Systems Based on Chitosan

Popescu

Ghica

Dinu-Pîrvu

et al. 2020

IJMS

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In an attempt to develop drug delivery systems that bypass the blood–brain barrier (BBB) and prevent liver and intestinal degradation, it was concluded that nasal medication meets these criteria and can be used for drugs that have these drawbacks. The aim of this review is to present the influence of the properties of chitosan and its derivatives (mucoadhesion, permeability enhancement, surface tension, and zeta potential) on the development of suitable nasal drug delivery systems and on the nasal bioavailability of various active pharmaceutical ingredients. Interactions between chitosan and proteins, lipids, antigens, and other molecules lead to complexes that have their own applications or to changing characteristics of the substances involved in the bond (conformational changes, increased stability or solubility, etc.). Chitosan and its derivatives have their own actions (antibacterial, antifungal, immunostimulant, antioxidant, etc.) and can be used as such or in combination with other molecules from the same class to achieve a synergistic effect. The applicability of the properties is set out in the second part of the paper, where nasal formulations based on chitosan are described (vaccines, hydrogels, nanoparticles, nanostructured lipid carriers (NLC), powders, emulsions, etc.).

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Rheological characterization of new thermosensitive hydrogels formed by chitosan, glycerophosphate, and phosphorylated β-cyclodextrin

Cited by 30 publications

References 68 publications

Thermoresponsive systems composed of poloxamer 407 and HPMC or NaCMC: mechanical, rheological and sol-gel transition analysis

Thermoresponsive systems composed of poloxamer 407 and HPMC or NaCMC: mechanical, rheological and sol-gel transition analysis

Synergistic Fabrication of Dose–Response Chitosan/Dextran/β-Glycerophosphate Injectable Hydrogel as Cell Delivery Carrier for Cardiac Healing After Acute Myocardial Infarction

New Opportunity to Formulate Intranasal Vaccines and Drug Delivery Systems Based on Chitosan

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