Rheological, mucoadhesive and release properties of Carbopol gels in hydrophilic cosolvents

Bonacucina, Giulia; Martelli, Sante; Palmieri, G

doi:10.1016/j.ijpharm.2004.06.012

Cited by 176 publications

(93 citation statements)

References 13 publications

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“…Color of GT was whitish orange with pH value was 5.59±0.02. The pH was suitable for active substance stability, especially for EGCG at pH 5.5 [32]. In addition, the pH of the gels was in the range of the pH of the skin (4.5-6.5).…”

Section: Gel Evaluationmentioning

confidence: 99%

Transfersomal Gel Containing Green Tea (Camellia Sinensis L. Kuntze) Leaves Extract: Increasing in Vitro Penetration

Anwar

Utami

Ramadon

2017

Asian J Pharm Clin Res

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Objective: The aim of this study was to increase penetration of epigallocatechin gallate (EGCG) from green tea leaves extract (Camellia sinensis L. Kuntz) through the skin by formulating the extract into a transfersomal gel (GT). Methods:Transfersomes were prepared by thin-layer hydration method, with different concentration of the extract that equivalent to 1% (F1), 1.5% (F2), and 2% (F3) of EGCG. A transfersomes formula with good characteristics would be incorporated into a GT. A gel without transfersomes (GNT) was prepared as a control of comparison. Both gels were evaluated their physicochemical properties. An in vitro penetration test using Franz diffusion cell with the skin of female Sprague-Dawley rats was also performed. Results:The results showed that F1 had the best physicochemical properties. F1 had a spherical shape, D mean volume at 107.82±0.44 nm, polydispersity index at 0.07±0.01, zeta potential at −40.3±0.10 mV, and entrapment efficiency at 63.16±0.65%. Cumulative amount of EGCG penetrated from GT and non-GT (GNT) Conclusion:It can be concluded that GT could increase the in vitro penetration of EGCG from green tea leaves extract compared to non-transfersomal one.

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Section: Gel Evaluationmentioning

confidence: 99%

Transfersomal Gel Containing Green Tea (Camellia Sinensis L. Kuntze) Leaves Extract: Increasing in Vitro Penetration

Anwar

Utami

Ramadon

2017

Asian J Pharm Clin Res

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“…An increase in the viscosity coefficient can be observed with the increase of pH, according to the ionization and, consequently, the swelling of the polymer net. 28 The structure of CHX contains 10 nitrogen atoms that enable bonding with the carboxyl groups in the PA. In a previous work, CHX with PA at a pH of approximately 5 formed a strong insoluble salt complex, resulting in a very weak CHX release, which is within the error range.…”

Section: Release Studymentioning

confidence: 99%

Application of an anionic polymer in the formulation of floating tablets containing an alkaline model drug

Wójcik-Pastuszka¹,

Golonka²,

Dryś³

et al. 2017

Adv Clin Exp Med

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“…For Newtonian samples the power law model gives n = 1 and K = 1, for a shear thinning (pseudo-plastic) fluid n < 1 and for a shear thickening (dilatant) fluid n > 1 [12].…”

Section: Rheologic Behavior and Dynamic Viscosity Determinationmentioning

confidence: 99%

Gelation of Sodium-Deoxycholate: Influenced by the Presence of a CorticosteroidBetamethasone-17-Valerate

Homan¹

2017

J. Drug

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This study was designed to evaluate the possible influences of betamethasone-17-valerate (BMV) on the gelation properties of sodium deoxycholate (Na-DOC), due to structural similarities as the monomer and the active agent. For this purpose gel formulations at two different concentrations, 0.05 and 0.1 % (w/w) were prepared and characterized by rheological and thermal analysis. The results indicated that the elastic moduli of the gels increased with increasing concentration of BMV in the system. This phenomenon was shown to be due to the modification of polymerization occurred by interactions between BMV and Na-DOC. The increment of BMV concentration in the formulation, caused a modification of the glass transition temperature (Tg) detected. Tg data pointed out a higher polymerization of Na-DOC with increasing amount of BMV. Transepidermal water loss measurements were also performed to evaluate possible skin irritation. It was observed that the degree of Na-DOC polymerization did not show any irritant effect on the skin.Overall, the results of this study clearly confirmed that incorporation of BMV into Na-DOC gel system produced a synergistic effect on product rheological characteristics, which would be beneficial for topical applications.

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Rheological, mucoadhesive and release properties of Carbopol gels in hydrophilic cosolvents

Cited by 176 publications

References 13 publications

Transfersomal Gel Containing Green Tea (Camellia Sinensis L. Kuntze) Leaves Extract: Increasing in Vitro Penetration

Transfersomal Gel Containing Green Tea (Camellia Sinensis L. Kuntze) Leaves Extract: Increasing in Vitro Penetration

Application of an anionic polymer in the formulation of floating tablets containing an alkaline model drug

Gelation of Sodium-Deoxycholate: Influenced by the Presence of a CorticosteroidBetamethasone-17-Valerate

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