Rheological properties of the gels of biological surfactant sodium deoxycholate/amino acids/halide salts systems

Sun, Xiaofeng; Du, Zongliang; Li, Enze; Xin, Xia; Tang, Na; Lin, Wang; Yuan, Jing

doi:10.1016/j.colsurfa.2014.06.003

Cited by 16 publications

(9 citation statements)

References 47 publications

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“…However, the hydrogels we developed are thixotropic in nature with less mechanical properties. The contribution of gel modifiers such as mannitol and Tris buffer to hydrogen bonding during gelation of Na-DOC has been reported [ 44 , 45 ]. Halide salts (NaCl, NaBr) as cross-linkers have been shown to improve the poor mechanical properties of the thixotropic Na-DOC gels [ 45 , 46 ], as the ions from the salts compressed the thick electric double layer and reduced the electrostatic repulsion of adjacent Na-DOC molecules at their polar heads [ 42 ].…”

Section: Resultsmentioning

confidence: 99%

“…The contribution of gel modifiers such as mannitol and Tris buffer to hydrogen bonding during gelation of Na-DOC has been reported [ 44 , 45 ]. Halide salts (NaCl, NaBr) as cross-linkers have been shown to improve the poor mechanical properties of the thixotropic Na-DOC gels [ 45 , 46 ], as the ions from the salts compressed the thick electric double layer and reduced the electrostatic repulsion of adjacent Na-DOC molecules at their polar heads [ 42 ]. As the mechanism illustrated in Figure 2 b the weak coordination bonds formed between the Na + ions and the carboxylate(-COO-) polar head of the Na-DOC molecules, and the electrostatic interaction due to Cl − and α-methylene moiety attached to the carboxylate group of the bile salt are also involved in the gelation of Na-DOC molecules [ 42 , 46 ].…”

Section: Resultsmentioning

confidence: 99%

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Bioinspired Composite, pH-Responsive Sodium Deoxycholate Hydrogel and Generation 4.5 Poly(amidoamine) Dendrimer Improves Cancer Treatment Efficacy via Doxorubicin and Resveratrol Co-Delivery

et al. 2020

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Maximizing the antitumor efficacy of doxorubicin (DOX) with a new drug delivery strategy is always desired in the field of biomedical science. Because the clinical applications of DOX in the treatment of cancer is limited by the side effects related to the dose. Herein, we report the co-loading of DOX and resveratrol (RESV) using an injectable in situ formed sodium deoxycholate hydrogel (Na-DOC-hyd) at the pH of the tumor extracellular microenvironment. The sequential, controlled, and sustained release of RESV and DOX for synergistic antitumor effects was confirmed by entrapping G4.5-DOX in the RESV-loaded Na-DOC hydrogel (Na-DOC-hyd-RESV). The synergistic antitumor activity of Na-DOC-hyd-RESV+G4.5-DOX was assessed on HeLa cell xenograft tumor in BALB/c nude mice. In the MTT biocompatibility assay, both the G4.5 PAMAM dendrimer and Na-DOC-hyd exhibited negligible cytotoxicity up to the highest dose of 2.0 mg mL−1 in HeLa, MDA-MB-231, and HaCaT cells. The release profiles of DOX and RESV from the Na-DOC-hyd-RESV+G4.5-DOX confirmed the relatively rapid release of RESV (70.43 ± 1.39%), followed by that of DOX (54.58 ± 0.62%) at pH 6.5 in the 7 days of drug release studies. A single intratumoral injection of Na-DOC-hyd-RESV+G4.5-DOX maximally suppressed tumor growth during the 28 days of the treatment period. Na-DOC-hyd-RESV+G4.5-DOX did not cause any histological damage in the major visceral organs. Therefore, this Na-DOC-hydrogel for dual drugs (DOX and RESV) delivery at the pH of the tumor extracellular microenvironment is a promising, safe, and effective combination for antitumor chemotherapy.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Bioinspired Composite, pH-Responsive Sodium Deoxycholate Hydrogel and Generation 4.5 Poly(amidoamine) Dendrimer Improves Cancer Treatment Efficacy via Doxorubicin and Resveratrol Co-Delivery

et al. 2020

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“…1A). In our previous work, it has also been demonstrated that inorganic salts can increase the mechanical strength of the hydrogel [29]. It is well known that GO nanosheets can act as reinforcing nanofillers to enhance the mechanical performance of hydrogel.…”

Section: Phase Behavior Of Nadc/go/pbs Mixed Systemmentioning

confidence: 97%

“…Before carrying out any oscillatory measurements, each sample should be checked to ensure that it is within the linear viscoelastic region where the storage modulus (G ) are independent of the applied stress [29,33]. G remain nearly constant with the increase in stress ( ) until the yield stress ( c ) is reached (Fig.…”

Section: Rheological Properties Of Nadc/go Hydrogelsmentioning

confidence: 99%

Effects of graphene oxide and salinity on sodium deoxycholate hydrogels and their applications in dye absorption

Wang

Xin

Yang

et al. 2015

Colloids and Surfaces A: Physicochemical and Engineering Aspect

Self Cite

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“…Theoretically, the connectivity can be described by the percolation model . The porous structure evolves with the probability ( p ) of the junctions that build up the connection . Once p reaches a critical value, porous structure is able to encompass the inner space of the material resulting in a 3D porous material, which distinguishes the states of gel from sol, and gel from glass for various materials .…”

Section: Figurementioning

confidence: 99%

Constructing Porous Carbon Nanomaterials using Redox-Induced Low Molecular Weight Hydrogels and their Application as Supercapacitors

Xie

Wang

2017

ChemistrySelect

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We synthesized porous carbon and Fe3O4@porous carbon by direct carbonization of redox‐induced low‐molecular‐weight hydrogels. The transition of low‐molecular‐weight hydrogels to hard porous carbons was observed for the first time. Conversely, the transformation of sol to porous carbon was not successful. This suggests that connectivity was a crucial factor distinguishing the porous materials from others. More importantly, it provides a new synthetic route for fabrication of porous materials. The porous carbons obtained exhibited excellent electrochemical properties as supercapacitors.

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Rheological properties of the gels of biological surfactant sodium deoxycholate/amino acids/halide salts systems

Cited by 16 publications

References 47 publications

Bioinspired Composite, pH-Responsive Sodium Deoxycholate Hydrogel and Generation 4.5 Poly(amidoamine) Dendrimer Improves Cancer Treatment Efficacy via Doxorubicin and Resveratrol Co-Delivery

Bioinspired Composite, pH-Responsive Sodium Deoxycholate Hydrogel and Generation 4.5 Poly(amidoamine) Dendrimer Improves Cancer Treatment Efficacy via Doxorubicin and Resveratrol Co-Delivery

Effects of graphene oxide and salinity on sodium deoxycholate hydrogels and their applications in dye absorption

Constructing Porous Carbon Nanomaterials using Redox-Induced Low Molecular Weight Hydrogels and their Application as Supercapacitors

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