Rheology and texture analysis of gelatin/dialdehyde starch hydrogel carriers for curcumin controlled release

Cui, Tianqi; Wu, Yue; Ni, Chunlei; Sun, Yu; Cheng, Jianjun

doi:10.1016/j.carbpol.2022.119154

Cited by 92 publications

(24 citation statements)

References 41 publications

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“…This great self-healing capacity was due to the dynamic imine bonds between amines and aldehydes groups, which acted as sacrificial bonds that were broken under high pressure, while readily reformed at small strain levels. 48,49 The self-healing capacity of the HP hydrogel makes it integral when injected into the vitreous cavity, which protects the loaded drug and prevents the tiny and dispersed particles from blocking aqueous humor circulation that leads to increased intraocular pressure. 23,50 3.3.…”

Section: Synthesis and Characterization Of Hydrogelsmentioning

confidence: 99%

Biomimetic, Injectable, and Self-Healing Hydrogels with Sustained Release of Ranibizumab to Treat Retinal Neovascularization

Duan

Mei

et al. 2023

ACS Appl. Mater. Interfaces

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Retinal neovascularization (RNV) is a typical feature of ischemic retinal diseases that can lead to traction retinal detachment and even blindness in patients, in which the vascular endothelial cell growth factor (VEGF) plays a pivotal role. However, most anti-VEGF drugs currently used for treating RNV, such as ranibizumab, need frequent and repeated intravitreal injections due to their short intravitreal half-life, which increases the incidence of complications. Herein, a hydrogel intravitreal drug delivery system (DDS) is prepared by a dynamic Schiff base reaction between aminated hyaluronic acid and aldehyde-functionalized Pluronic 127 for sustained release of ranibizumab. The prepared hydrogel system named HP@Ran exhibits excellent injectability, self-healing ability, structural stability, cytocompatibility, and blood compatibility. According to an in vitro drug release study, the hydrogel system continuously releases the model drug bovine serum albumin for more than 56 days. Importantly, in an in vivo rabbit persistent RNV model, the HP@Ran hydrogel system continuously releases pharmacologically active ranibizumab for more than 7 weeks and also exhibits superior anti-angiogenic efficacy over ranibizumab treatment by decreasing vascular leakage and neovascularization at 12 weeks. Thus, the developed HP@Ran hydrogel system possesses great potential for intravitreal DDS for the treatment of RNV.

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Section: Synthesis and Characterization Of Hydrogelsmentioning

confidence: 99%

Biomimetic, Injectable, and Self-Healing Hydrogels with Sustained Release of Ranibizumab to Treat Retinal Neovascularization

Duan

Mei

et al. 2023

ACS Appl. Mater. Interfaces

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“…With the increase in frequency, a crossover value is reported [ 43 ]. At this time, the loss modulus G’ curve and the storage modulus G” curve was close to or intersected, which also meant that the crossover value was negatively correlated with the elastic contribution at the beginning of the elastic behavior [ 44 ]. With the further increase in oscillation frequency, G’ began to exceed G”, which indicated that the elastic properties were dominant.…”

Section: Resultsmentioning

confidence: 99%

Interaction between Gelatin and Mulberry Leaf Polysaccharides in Miscible System: Physicochemical Characteristics and Rheological Behavior

Zhang

Liao

Guan

et al. 2022

Foods

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In this study, the miscible system was formed by mixing gelatin (G) with mulberry leaf polysaccharides (MLPs) continuously extracted with a hot buffer (HBSS), a chelating agent (CHSS), a dilute alkali (DASS), and a concentrated alkali (CASS), and the zeta potential, turbidity, particle size, distribution, and rheological properties of the miscible systems were evaluated. Under acidic conditions, the miscible systems of four polysaccharides and gelatin were in a clear state; under alkaline conditions, G-HBSS and G-CHSS were clarified, and G-DASS and G-CASS changed from clarification to turbidity. The zeta potential changed from positive to negative with the increase in pH. When the pH was at 7, it increased with the increase in polysaccharide concentration but was still negative. The four miscible systems all showed polydispersity. The particle sizes of G-HBSS and G-CHSS decreased with the increase in pH, while the particle sizes of G-DASS and G-CASS were increased. The four miscible systems showed “shear thinning” behavior, and the addition of gelatin reduced the apparent viscosity of the four polysaccharide solutions. G-CHSS was highly stable, and G-CASS was more suitable as a stabilizer in the freezing process.

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“…at the same time, the creep‐recovery curves decreased gradually (SME2 > SMA2 > SMM2, SME1 > SMA1 > SMM1), indicating that the high concentration of S.M. extracts enhanced the rigidity and resistance to deformation of dough, which was related to the enhancement of molecular forces and covalent cross‐linking (Cui et al ., 2022). These results are by Kotsiou et al .…”

Section: Resultsmentioning

confidence: 99%

Physical properties and hypoglycaemic activity of biscuits as affected by the addition of stigma maydis extract

Yao

Zhang

Qiao

et al. 2022

Int J of Food Sci Tech

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Summary The study aimed to evaluate the potential ingredient of stigma maydis (S.M.) as a hypoglycaemic functional food. In the present study, waxy corn flour and corn‐resistant starch were used to make biscuits; the influence of S.M. extracts (aqueous extract, SMA; ethanol extract, SME; mixed solvent extract, SMM) on the physical features and in vitro digestibility of biscuit were surveyed. In the meantime, the α‐amylase and α‐glucosidase inhibition of different S.M. extracts were analysed. Compared with the control dough, 5% ethanol S.M. extract (SME2) dough was observed to have the lowest storage modulus (G'), loss modulus (G"), hardness, water absorption capacity (P < 0.05), while creep strain was the highest (P < 0.05). Adding S.M. extracts could significantly reduce the L*, b* value and increase the a* value of biscuits. Besides, the S.M. extracts could decrease the glycaemic index (G.I.) of biscuits and reduce postprandial blood glucose levels. The GI of SMA1, SMA2, SME1, SME2, SMM1 and SMM2 was decreased to 62.47, 55.17, 51.46, 44.89, 53.05 and 50.11 respectively. Further, the addition of S.M. extract could show a certain inhibitory rate of α‐amylase and α‐glucosidase when added to biscuits. The inhibition ratio of 5% extract (SMA2, SME2 and SMM2) biscuit was higher than that of 1% extract (SMA1, SME1 and SMM1) biscuit (P < 0.05). As a natural functional component, S.M. extract could be a potential food supplement for type II diabetic mellitus.

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Rheology and texture analysis of gelatin/dialdehyde starch hydrogel carriers for curcumin controlled release

Cited by 92 publications

References 41 publications

Biomimetic, Injectable, and Self-Healing Hydrogels with Sustained Release of Ranibizumab to Treat Retinal Neovascularization

Biomimetic, Injectable, and Self-Healing Hydrogels with Sustained Release of Ranibizumab to Treat Retinal Neovascularization

Interaction between Gelatin and Mulberry Leaf Polysaccharides in Miscible System: Physicochemical Characteristics and Rheological Behavior

Physical properties and hypoglycaemic activity of biscuits as affected by the addition of stigma maydis extract

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