Rheology as a tool for evaluation of melt processability of innovative dosage forms

Aho, Johanna; Boetker, Johan; Baldursdóttir, Stefanía; Rantanen, Jukka

doi:10.1016/j.ijpharm.2015.02.009

Cited by 166 publications

(158 citation statements)

References 92 publications

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“…A constant torque plateau, is an indicative of absence of degradation during polymer processing. [14][15][16] Figure 2 shows temperature and torque versus time plots for PCL/bentonite compounds up to 20% w/w clay content. PCL/MMT compounds show constant temperature and torque plateaus for 20 minutes processing time, evidencing absence of molecular weight decaying.…”

Section: -13supporting

confidence: 82%

Hydrolytic and Thermal Degradation of PCL and PCL/Bentonite Compounds

et al. 2016

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Section: -13supporting

confidence: 82%

Hydrolytic and Thermal Degradation of PCL and PCL/Bentonite Compounds

et al. 2016

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“…At the same time the results highlight that the accuracy of the production of a specific CAD model highly depends on the material properties of the feed materials and the design of the printed geometry. In particular, a thorough understanding of the rheology of the filament is necessary to produce high quality prints (31). …”

Section: Resultsmentioning

confidence: 99%

Analysis of 3D Prints by X-ray Computed Microtomography and Terahertz Pulsed Imaging

et al. 2016

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PurposeA 3D printer was used to realise compartmental dosage forms containing multiple active pharmaceutical ingredient (API) formulations. This work demonstrates the microstructural characterisation of 3D printed solid dosage forms using X-ray computed microtomography (XμCT) and terahertz pulsed imaging (TPI).MethodsPrinting was performed with either polyvinyl alcohol (PVA) or polylactic acid (PLA). The structures were examined by XμCT and TPI. Liquid self-nanoemulsifying drug delivery system (SNEDDS) formulations containing saquinavir and halofantrine were incorporated into the 3D printed compartmentalised structures and in vitro drug release determined.ResultsA clear difference in terms of pore structure between PVA and PLA prints was observed by extracting the porosity (5.5% for PVA and 0.2% for PLA prints), pore length and pore volume from the XμCT data. The print resolution and accuracy was characterised by XμCT and TPI on the basis of the computer-aided design (CAD) models of the dosage form (compartmentalised PVA structures were 7.5 ± 0.75% larger than designed; n = 3).ConclusionsThe 3D printer can reproduce specific structures very accurately, whereas the 3D prints can deviate from the designed model. The microstructural information extracted by XμCT and TPI will assist to gain a better understanding about the performance of 3D printed dosage forms.Electronic supplementary materialThe online version of this article (doi:10.1007/s11095-016-2083-1) contains supplementary material, which is available to authorized users.

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“…In order to prevent breakdown of the material, the printing temperature should be kept at a range higher than the glass transition temperature but lower than the thermal molecular decomposition temperature. Particularly in extrusion printing, rheology is an important factor to evaluate, which can be utilized as a further guide to determine the fabricating conditions [22]. The rheological properties of five types of PLGA were analyzed.…”

Section: Discussionmentioning

confidence: 99%

3D printing PLGA: a quantitative examination of the effects of polymer composition and printing parameters on print resolution

et al. 2017

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In the past few decades, 3D printing has played a significant role in fabricating scaffolds with consistent, complex structure that meet patient-specific needs in future clinical applications. Although many studies have contributed to this emerging field of additive manufacturing, which includes material development and computer-aided scaffold design, current quantitative analyses do not correlate material properties, printing parameters, and printing outcomes to a great extent. A model that correlates these properties has tremendous potential to standardize 3D printing for tissue engineering and biomaterial science. In this study, we printed poly(lactic-co-glycolic acid) (PLGA) utilizing a direct melt extrusion technique without additional ingredients. We investigated PLGA with various lactic acid: glycolic acid (LA:GA) molecular weight ratios and end caps to demonstrate the dependence of the extrusion process on the polymer composition. Micro-computed tomography was then used to evaluate printed scaffolds containing different LA:GA ratios, composed of different fiber patterns, and processed under different printing conditions. We built a statistical model to reveal the correlation and predominant factors that determine printing precision. Our model showed a strong linear relationship between the actual and predicted precision under different combinations of printing conditions and material compositions. This quantitative examination establishes a significant foreground to 3D print biomaterials following a systematic fabrication procedure. Additionally, our proposed statistical models can be applied to couple specific biomaterials and 3D printing applications for patient implants with particular requirements.

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Rheology as a tool for evaluation of melt processability of innovative dosage forms

Cited by 166 publications

References 92 publications

Hydrolytic and Thermal Degradation of PCL and PCL/Bentonite Compounds

Hydrolytic and Thermal Degradation of PCL and PCL/Bentonite Compounds

Analysis of 3D Prints by X-ray Computed Microtomography and Terahertz Pulsed Imaging

3D printing PLGA: a quantitative examination of the effects of polymer composition and printing parameters on print resolution

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