Rheology of fibrous gels under compression

Sun, Chuanpeng; Purohit, Prashant K.

doi:10.1016/j.eml.2022.101757

Cited by 8 publications

(2 citation statements)

References 25 publications

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“…The G ′ and G ″ together reflected the viscoelastic behavior of the gel. G ′ arises from the elasticity of the fiber network, while G ′′ depends on the energy dissipation of material caused by liquid flow through pores . The gels with different concentrations at pH 7.7 and with different pH at a concentration of 1.5 wt % were prepared using the method in 2.3.3 to investigate the effect of concentration and pH value on the rheological properties, respectively.…”

Section: Resultsmentioning

confidence: 99%

Gelation Behavior and Drug Sustained-Release Properties of a Helix Peptide Organohydrogel with pH Responsiveness

Zhang,

Zhao,

et al. 2024

Langmuir

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Based on the typical similar repeat units (abcdefg) n of α-helical structure, the peptide H was designed to self-assemble into an organohydrogel in response to pH. Depending on the different pH, the proportions of secondary structure, microstructure, and mechanical properties of the gel were investigated. Circular dichroism (CD) and Fourier transform infrared (FT-IR) showed that the proportion of α-helical structure gradually increased to become dominant with the increase of pH. Combining transmission electron microscopy (TEM) and atomic force microscopy (AFM), it was found that the increase of the ordered α-helix structure promoted fiber formation. The further increase in pH changed the intermolecular forces, resulting in an increase in the α-helix content and the enhancement of helix–helix interaction, causing the gel fibers to converge into thicker and more dense ones. The temperature test showed the stable rheological properties of the organohydrogel between 20–60 °C. Drug release and cytotoxicity showed that the DOX-loaded organohydrogel could have a better release in an acidic environment, indicating its potential application as a drug local delivery carrier.

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Section: Resultsmentioning

confidence: 99%

Gelation Behavior and Drug Sustained-Release Properties of a Helix Peptide Organohydrogel with pH Responsiveness

Zhang,

Zhao,

et al. 2024

Langmuir

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“…The characteristic strain-induced structural changes of fibrin presented in this work not only give insight into the mechanism of fibrin rupture but may provide the mechanistic basis for rupture of other fibrous gels. 24 …”

Section: Introductionmentioning

confidence: 99%

Mechanics and microstructure of blood plasma clots in shear driven rupture

Ramanujam,

Garyfallogiannis,

Litvinov

et al. 2024

Soft Matter

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An injectable hydrogel of porcine cholecyst extracellular matrix for accelerated wound healing

Pratheesh,

Nair,

Purnima

et al. 2024

J Biomedical Materials Res

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Hydrogel formulations of xenogeneic extracellular matrices have been widely used for topical wound care because of their exceptional tunability over other formulations like lyophilized sheets, powders, non‐injectable gels, pastes, and ointments. This is important in the treatment of wounds with irregular shapes and depth. This study identified an injectable hydrogel formulation of porcine cholecyst extracellular matrix (60%) in medical‐grade carboxymethyl cellulose (40%) as vehicle and evaluated its biomaterial properties. Further, an in‐depth evaluation of in vivo wound healing efficacy was conducted in a rat full‐thickness skin excision wound healing model, which revealed that the hydrogel formulation accelerated wound healing process compared to wounds treated with a commercial formulation and untreated wounds. The hydrogel appeared to have promoted a desirable pro‐regenerative tissue reaction predominated by Th2 helper lymphocytes and M2 macrophages as well as an effective collagen remodeling indicative of diminished scarring. In conclusion, the porcine cholecyst extracellular matrix injectable hydrogel formulation appeared to be a promising candidate formulation as an advanced wound care biomaterial for faster healing of skin wounds with minimal scarring.

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Rheology of fibrous gels under compression

Cited by 8 publications

References 25 publications

Gelation Behavior and Drug Sustained-Release Properties of a Helix Peptide Organohydrogel with pH Responsiveness

Gelation Behavior and Drug Sustained-Release Properties of a Helix Peptide Organohydrogel with pH Responsiveness

Mechanics and microstructure of blood plasma clots in shear driven rupture

An injectable hydrogel of porcine cholecyst extracellular matrix for accelerated wound healing

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