Rheology of Human Blood. Studies on the Flow of Fresh Venous Blood and of Citrated Blood Through Tubing of Diameters Between 0.09 and 0.20 Cm

Dreizen, Paul

doi:10.1172/jci104662

Cited by 10 publications

(4 citation statements)

References 41 publications

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“…While we aimed to replicate conditions likely to exist in the clinical situation in both components of the study, we recognise that there were a number of possible limitations. For the in vitro component, citrated whole blood would differ in its rheology and interfacial properties to blood in vivo [7][8] . The use of a single fresh unit on a single day, together with consecutive measurements alternating unflushed and flushed catheters, aimed to minimise other potential sources of variability.…”

Section: Discussionmentioning

confidence: 99%

“…Blood is a complex non-Newtonian (thixotropic and viscoelastic) fluid, the viscosity of which depends on many factors, including the shear rate or velocity of flow, time of shearing, as well as a number of patient specific factors 6,7 . In addition, changes in its interfacial properties (interfacial tension and contact angle) may occur upon exposure to air.…”

Section: Appendixmentioning

confidence: 99%

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The Influence of Flushing Epidural Catheters before use on Detection of Intravenous Placement: An in Vitro and in Vivo Study

O’Connor

Leslie

2007

Anaesth Intensive Care

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Undetected intravenous placement of epidural catheters is rare but potentially fatal and no perfect identification method exists. Epidural catheters may be flushed before insertion to identify faulty epidural catheters, or to prime the system with local anaesthetic. We hypothesised that flushing epidural catheters before insertion may delay the detection of intravenous placement. We investigated our theory using both in vitro and in vivo models. The in vitro component examined flowrates in flushed and unflushed epidural catheters, using conditions designed to mimic epidural venous pressure. The in vivo component examined the flow within flushed and unflushed epidural catheters inserted into the forearm veins of 20 anaesthetised patients, using a randomised crossover design. The end-point utilised for both components was the time taken for frank blood to reach the 20 cm mark on the epidural catheter. Blood flow to the 20 cm mark on the epidural catheter was significantly faster in the unflushed catheters than the flushed catheters, both in vitro and in vivo (in vitro, unflushed median = 18.6 s (range: 18.0 to 20.5 s), flushed 37.6 s (32.6 to 91.2 s), P=0.0009; in vivo, unflushed 9.2 seconds (range 5.0 to 35.3 s), flushed 19.2 s (10.6 to 47.4 s), P=0.003 in vivo). Flushed catheters also demonstrated a greater variability in the range of flowrates. Flushing epidural catheters before insertion may delay the detection of intravenous placement.

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Section: Discussionmentioning

confidence: 99%

Section: Appendixmentioning

confidence: 99%

The Influence of Flushing Epidural Catheters before use on Detection of Intravenous Placement: An in Vitro and in Vivo Study

O’Connor

Leslie

2007

Anaesth Intensive Care

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“…Although the blood viscosity is almost as low as that of water, it shows remarkable dependence on the shear rate determined by the flow velocity and the diameter of the vessel. [22][23][24] Typical values are approximately 10 mPa • s and 4 mPa • s at the shear rate of 30 s −1 and 600 s −1 , respectively. This range of the shear rate corresponds to that of an actual flow in a human body; lower shear rate for thicker vessels and higher shear rate for thinner vessels.…”

Section: Introductionmentioning

confidence: 99%

In-vitro evaluation of blood fluidity using an electromagnetically spinning rheometry system

Hirano¹,

Mitani

Sakai

2019

Jpn. J. Appl. Phys.

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Viscosity is an essential physical property for determining blood fluidity, which shows remarkable dependence on shear rate. In this study, we introduce a newly developed rheometry system with high sensitivity applicable for in-vitro evaluation of fluidity of blood. A new auto-balancing rotor has been designed, which improves the measurement accuracy even for low viscosity at low shear rate. Our system measures the viscosity of completely confined sample avoiding contamination from/to samples. These features are suitable for quantitative analysis of bio-component solutions, including bloods. The system was applied to measurement of viscosity curves of human fresh bloods. The obtained results clearly showed reasonable difference among the individuals, and the measurement range of the shear rate were sufficiently wide to reproduce the actual blood flow in all kinds of vessels.

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“…12,13) The typical viscosity of human blood ranges between 4 and 10 mPa s at a shear rate that, in the bloodstream of a single body, ranges between 30 and 600 s −1 . [14][15][16] Therefore, viscosity curves representing the dependence of viscosity on shear deformation rate must be measured for more accurate simulation. In viscometry, conventional methods have two critical issues in measuring blood viscosity.…”

mentioning

confidence: 99%

Fluidity measurement of human and synthetic analogous bloods using an electromagnetically spinning rheometry system

Hirano¹,

Mitani²,

Sakai³

2020

Jpn. J. Appl. Phys.

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We developed an electromagnetically spinning viscometer and applied it to the rheological measurements for biohazardous samples such as bloods. Blood fluidity can be evaluated from the measurement of viscosity curves, which show shear thinning behaviors mainly due to deformation of blood cells. In this study, we fabricated gel-like microparticles with different softness using our inkjet technique and investigated the difference of fluidity for their dispersions. The results show that the viscosity curves depend on the softness of the dispersed particles: The fluidity for the dispersion of moderate soft particles is quite similar to that of the human blood.

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Rheology of Human Blood. Studies on the Flow of Fresh Venous Blood and of Citrated Blood Through Tubing of Diameters Between 0.09 and 0.20 Cm

Cited by 10 publications

References 41 publications

The Influence of Flushing Epidural Catheters before use on Detection of Intravenous Placement: An in Vitro and in Vivo Study

The Influence of Flushing Epidural Catheters before use on Detection of Intravenous Placement: An in Vitro and in Vivo Study

In-vitro evaluation of blood fluidity using an electromagnetically spinning rheometry system

Fluidity measurement of human and synthetic analogous bloods using an electromagnetically spinning rheometry system

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