Antigorite occurs at seismogenic depth along plate boundary shear zones, particularly in subduction and oceanic transform settings, and has been suggested to control a low‐strength bulk rheology. To constrain dominant deformation mechanisms, we perform hydrothermal ring‐shear experiments on antigorite and antigorite‐quartz mixtures at temperatures between 20 and 500°C at 150 MPa effective normal stress. Pure antigorite is strain hardening, with frictional coefficient (μ) > 0.5, and developed cataclastic microstructures. In contrast, antigorite‐quartz mixtures (10% quartz) are strain weakening with μ decreasing with temperature from 0.36 at 200°C to 0.22 at 500°C. Antigorite‐quartz mixtures developed foliation similar to natural serpentinite shear zones. Although antigorite‐quartz reactions may form mechanically weak talc, we only find small, localized amounts of talc in our deformed samples, and room temperature friction is higher than expected for talc. Instead, we propose that the observed weakening at temperatures ≥200°C primarily results from silica dissolution leading to a lowered pore‐fluid pH that increases antigorite solubility and dissolution rate and thus the rate of dissolution‐precipitation creep. We suggest that under our experimental conditions, efficient dissolution‐precipitation creep coupled to grain boundary sliding results in a mechanically weak frictional‐viscous rheology. Antigorite with this rheology is much weaker than antigorite deforming frictionally, and strength is sensitive to effective normal stress and strain rate. The activation of dissolution‐precipitation in antigorite may allow steady or transient creep at low driving stress where antigorite solubility and dissolution rate are high relative to strain rate, for example, in faults juxtaposing serpentinite with quartz‐bearing rocks.