Rheology of Sodium Hyaluronate under Physiological Conditions

Krause, Wendy E.; Bellomo, Enrico G.; Colby, Ralph H.

doi:10.1021/bm0055798

Cited by 206 publications

(221 citation statements)

References 44 publications

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“…However, at the length scales smaller than the solution correlation length the strong electrostatic coupling between sections of the chain still persists and determines the characteristic relaxation time of these chain's sections. This dependence of the chain relaxation time is in a good qualitatively agreement with the experimental data by Colby's group 14,15,21,23 on the variety of the polyelectrolyte systems and is the main reason behind the famous Fuoss law for the concentration dependence of the polyelectrolyte solution viscosity.…”

Section: Discussionsupporting

confidence: 88%

Rouse Dynamics of Polyelectrolyte Solutions: Molecular Dynamics Study

et al. 2007

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We performed molecular dynamics simulations of dilute and semidilute polyelectrolyte solutions without hydrodynamic interactions to study Rouse dynamics of polyelectrolytes. Polyelectrolyte solutions are modeled by an ensemble of bead-spring chains of charged Lennard-Jones particles with explicit counterions. The simulations were performed for partially and fully charged polymers with the number of monomers N ) 25-373. We show that the simulations of the Rouse dynamics give qualitatively similar results to the experimentally observed dynamics of polyelectrolyte solutions. Our simulations showed that the chain relaxation time depends nonmonotonically on polymer concentration. In dilute solutions, this relaxation time exhibits very strong dependence on the chain degree of polymerization, τ ∼ N 3 . The chain relaxation time decreases with increasing polymer concentration of dilute solutions. This decrease in the chain relaxation time is due to chain contraction induced by counterion condensation. In the semidilute solution regime the chain relaxation time decreases with polymer concentration as c -1/2 . In this concentration range the chain relaxation time follows the usual Rouse scaling dependence on the chain degree of polymerization, τ ∼ N 2 . At high polymer concentrations the chain relaxation time begins to increase with increasing polymer concentration. The crossover polymer concentration to the new scaling regime does not depend on the chain degree of polymerization, indicating that the increase in the chain relaxation time is due to the increase of the effective monomeric friction coefficient. The analysis of the spectrum and of the relaxation times of Rouse modes confirms the existence of the single correlation length , which describes both static and dynamic properties of semidilute solutions.

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Section: Discussionsupporting

confidence: 88%

Rouse Dynamics of Polyelectrolyte Solutions: Molecular Dynamics Study

et al. 2007

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“…% are dissolved in the phosphatebuffered saline (PBS, Sigma Aldrich, Japan), and in water at different salt concentrations (sodium chloride, NaCl). PBS contains mainly 138 mM of NaCl and 2.7 mM of KCl, and is a widely used physiological buffer for biological samples [37,43]. The molecular weight dispersity of HA samples similar to that used here is typically reported to be within the range 1.1 < M w =M n < 1.2 [47,48,54].…”

Section: A Materialsmentioning

confidence: 82%

“…In this work, we deal with polyelectrolytes in a good solvent and in the presence of large amount of salt, i.e., in the so-called high-salt limit. In this case, scalings are identical [37] to those for uncharged polymer in a good solvent [Eqs. (1)- (3) with ¼ 0.6], because electrostatic interactions between the charges on the polyelectrolyte are analogous to the excluded volume [38,39].…”

Section: Theoretical Backgroundmentioning

confidence: 99%

Relaxation time of dilute polymer solutions: A microfluidic approach

2017

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“…This value of intrinsic viscosity gives a viscosity averaged molecular weight of the HA used in this study of 1.2 3 10 6 g mol 21 , agreeing with M w values reported for bacterial HA falling within the range of 7.9 3 10 5 to 1.9 3 10 6 g mol 21 . 34,37 Experimental Conditions for Gel formation Different experimental conditions were tested in order to obtain hyaluronan (HA) gels of high mechanical stability and fast responsivity. As detailed in the experimental section, aqueous HA solutions in the presence of EGDE crosslinker were subjected to gelation in plastic syringes for four days.…”

Section: Fourier Transform-infrared (Ft-ir) Spectrometermentioning

confidence: 99%

Preparation and physical properties of hyaluronic acid‐based cryogels

Ström

Larsson

Okay

2015

J of Applied Polymer Sci

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Macroporous hydrogels based on hyaluronan (HA), a natural polysaccharide occurring in extracellular matrix, have attracted interest over many years owing to their numerous applications in the biomedical area. However, HA hydrogels produced so far suffer from low mechanical strength and slow rate of response against external stimuli, which limit their applications. Here, we prepared macroporous HA cryogels of high mechanical stability and fast responsivity from aqueous HA solutions at subzero temperatures using ethylene glycol diglycidyl ether as a crosslinking agent. HA cryogels are squeezable and no crack development was exhibited when compressed up to 80% strain. Depending on the synthesis parameters, the cryogels exhibit an elastic modulus between 0.2 and 2 kPa, and show fast swelling/deswelling behavior. The microstructure of the cryogels consists of large, interconnected pores on the order of 100 mm separated by thick pore walls, as observed by scanning electron microscopy and confocal scanning laser microscopy.

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Rheology of Sodium Hyaluronate under Physiological Conditions

Cited by 206 publications

References 44 publications

Rouse Dynamics of Polyelectrolyte Solutions: Molecular Dynamics Study

Rouse Dynamics of Polyelectrolyte Solutions: Molecular Dynamics Study

Relaxation time of dilute polymer solutions: A microfluidic approach

Preparation and physical properties of hyaluronic acid‐based cryogels

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