Rheum tanguticum polysaccharide alleviates DSS-induced ulcerative colitis and regulates intestinal microbiota in mice

Zhang, Yan; Liu, Ying; Luo, Jian; Liu, Yong; Yu, Siyu; Liu, Jia

doi:10.1016/j.fbio.2023.102788

Cited by 11 publications

(1 citation statement)

References 61 publications

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“…Multiple research studies [54][55] have shown a connection between abnormalities in the gut microbiota and the development of many diseases, including UC. In line with other findings [56] , we also noticed in our investigation that the digestive tracts of UC mice had less microbial diversity.…”

Section: Spp Can Increase the Content Of Scfas In The Intestines Of U...mentioning

confidence: 99%

Silkworm pupa peptide ameliorates dextrose sodium sulfate-induced colitis by enhancing gut barriers and modifying gut flora

Zhou,

Wang,

Duan

et al. 2024

Food Science and Human Wellness

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The anti-inflammatory properties of silkworm pupa peptide (SPP) have been recognized for their potential benefits in colitis treatment. However, the underlying mechanism of SPP in colitis animal models remains unclear. The objective of our work was to investigate the improving effect and the mechanism of action of SPP on a mouse model of dextrose sodium sulfate (DSS)-induced colitis. The findings suggested that SPP effectively eased ulcerative colitis (UC) symptoms in mice by decreasing disease activity index, ameliorating histopathological injury, and decreasing serum and colonic markers of inflammation. In addition, our research findings demonstrated that SPP restored intestinal barrier function by increasing the production of tight junction proteins such as zonula occludens-1 (ZO-1), claudin-1, claudin-3, occludin, and adherens junction protein E-cadherin1. Further, SPP supplementation enhanced the concentration of short-chain fatty acids and positively altered the makeup of the gut bacteria in the mice's gut. These findings underscore SPP's ability to slow the progression of colitis and point to its possible use as a functional component in dietary supplements for the prevention of early-stage colitis.

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Section: Spp Can Increase the Content Of Scfas In The Intestines Of U...mentioning

confidence: 99%

Silkworm pupa peptide ameliorates dextrose sodium sulfate-induced colitis by enhancing gut barriers and modifying gut flora

Zhou,

Wang,

Duan

et al. 2024

Food Science and Human Wellness

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Dictyophora indusiata polysaccharide attenuated LPS‐induced intestinal inflammation of mice via the TLR4/JNK signaling pathway

Zhang,

Zeng,

Wang

et al. 2024

J Sci Food Agric

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BACKGROUNDDictyophora indusiata polysaccharide is an important bioactive component of D. indusiata, playing an important role in alleviating inflammation. The present study aimed to investigate the anti‐inflammatory effect and mechanism of D. indusiata polysaccharide on lipopolysaccharide (LPS)‐induced intestinal inflammation in mice.RESULTSOur results indicated that D. indusiata polysaccharide ameliorated intestinal inflammation of mice by increasing the body weight, the number of goblet cells and decreasing inflammatory cell infiltration. In addition, D. indusiata polysaccharide significantly up‐regulated expression of ZO‐1, Occuldin mRNA, which were 2.55‐fold and 2.28‐fold higher than the LPS group, respectively. In particular, D. indusiata polysaccharide effectively inhibited the Toll‐like receptor 4 (TLR4)/ c‐Jun NH2‐terminal kinase (JNK) signalling pathway which was 0.34‐fold and 0.49‐fold of gene expression and 0.41‐fold and 0.39‐fold of protein expression in the LPS group, respectively.CONCLUSIONThe results of the present study suggested that D. indusiata polysaccharide exerted anti‐inflammatory and intestinal protective effects by inhibiting the TLR4/JNK signaling pathway, which will provide a basis for the potential value of D. indusiata polysaccharide as prebiotics in food applications. © 2024 Society of Chemical Industry.

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Natural approaches for the management of ulcerative colitis: evidence of preclinical and clinical investigations

Subudhi,

Poonia,

Singh

et al. 2024

Nat. Prod. Bioprospect.

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Ulcerative colitis (UC) is a recurring autoimmune disorder characterized by persistent inflammation in the mucosal lining of the lower part of the large intestine. Conventional treatment options such as salicylates, corticosteroids, and immunosuppressants often come with severe side effects, limited bioavailability, and the development of drug resistance, which hampers their therapeutic effectiveness. Therefore, it is imperative to explore natural strategies as safe and alternative treatments for UC. Currently, around 40% of UC patients find relief through natural constituents, which can help reduce toxic side effects and maintain clinical remission. This review aims to provide a summary of both preclinical and clinical evidence supporting the efficacy of various natural substances in the prophylaxis of UC. These natural options include plant extracts, essential oils, nutraceuticals, and phytochemicals. Furthermore, we will delve into the potential mechanisms that underlie the protective and curative actions of these novel herbal agents. In summary, this review will explore the effectiveness of natural remedies for UC, shedding light on their preclinical and clinical findings and the mechanisms behind their therapeutic actions. These alternatives offer hope for improved treatment outcomes and reduced side effects for individuals suffering from this challenging autoimmune condition. Graphical Abstract

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Rheum tanguticum polysaccharide alleviates DSS-induced ulcerative colitis and regulates intestinal microbiota in mice

Cited by 11 publications

References 61 publications

Silkworm pupa peptide ameliorates dextrose sodium sulfate-induced colitis by enhancing gut barriers and modifying gut flora

Silkworm pupa peptide ameliorates dextrose sodium sulfate-induced colitis by enhancing gut barriers and modifying gut flora

Dictyophora indusiata polysaccharide attenuated LPS‐induced intestinal inflammation of mice via the TLR4/JNK signaling pathway

Natural approaches for the management of ulcerative colitis: evidence of preclinical and clinical investigations

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