Rheumatic Diseases and Molecular Physical Medicine – New Aspects

Lange, U.; Müller‐Ladner, Ulf; Dischereit, Gabriel

doi:10.1055/s-0043-113045

Cited by 11 publications

(7 citation statements)

References 24 publications

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“…At the other end of the thermotherapy spectrum, it has been shown that hyperthermia also alters cytokine levels [24]. Nowadays, physical therapy has been shown to change molecular parameters, which explains its profound and beneficial effects in rheumatic diseases [25].…”

Section: Introductionmentioning

confidence: 99%

Serial whole-body cryotherapy in fibromyalgia is effective and alters cytokine profiles

et al. 2021

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Introduction Whole-body cryotherapy (WBC) has shown to be beneficial in the treatment of fibromyalgia (FM). There is cumulative evidence that cytokines play a crucial role in FM. It’s unknown whether clinical effects of WBC can be demonstrated at the molecular level and how long the effects last. Methods We compared effects of serial WBC (6 sessions (− 130 °C in 6 weeks) in FM patients and healthy controls (HC). Primary outcome was the change in pain level (visual analogue scale 0–100 mm) after 6 sessions. Secondary outcomes were a change in disease activity (revised Fibromyalgia Impact Questionnaire) and pain after 3 sessions and 3 months after discontinued therapy and in cytokine levels (interleukin (IL-)1, IL-6, tumor necrosis factor α (TNF-α) and IL-10). The patients’ opinions on the satisfaction, effectiveness and significance of WBC were evaluated. Results Twenty-three FM patients and 30 HC were enrolled. WBC resulted in a significant reduction in pain and disease activity after 3 and 6 sessions. No clinical benefit could be measured 3 months after discontinued treatment. Overall, probands were satisfied with WBC and considered WBC to be important and effective. FM patients had significantly different levels of IL-1, IL-6, TNF-α and IL-10 at each reading point compared to HC. Levels of IL-1, IL-6 and IL-10 were significantly altered over time in FM patients. Compared to HC FM patients showed a significantly different response of IL1, − 6 and − 10 to WBC. Conclusion Serial WBC is a fast acting and effective treatment for FM. Proven effects of WBC may be explained by changes in cytokines.

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Section: Introductionmentioning

confidence: 99%

Serial whole-body cryotherapy in fibromyalgia is effective and alters cytokine profiles

et al. 2021

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“…pertaining to rheumatic and musculoskeletal diseases generally conclude that most of the included studies have shown a clinical efficacy of spa therapy/ balneotherapy; however, more high-quality studies are needed to draw firm conclusions [3,[7][8][9][10][11]. Some evidence exists on mechanisms by which balneotherapy may improve the clinical symptoms of patients [12][13][14][15]. Notably, in some spa therapy studies, all the clinical benefits could not only be attributed to balneotherapy, as complex spa therapy programs include the other balneological treatments, physical therapy modalities, and/ or exercise.…”

Section: Clinical Medcine Hypothesismentioning

confidence: 99%

Pathophysiological Mechanisms of Balneotherapy With Potential Implications for Central Asian Spas and Sanatoriums

Kardeş

Karagülle

2021

CAJMHE

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Spa therapy includes all modalities/ treatments based on evidence that are administered in spas or sanatoriums. Balneotherapy, the immersion in mineral water, is the main balneological modality in spa therapy programs. Clinical trials performed in Europe, Turkey, and Israel have shown clinical benefits of spa therapy/ balneotherapy in several diseases mainly pertaining to rheumatic and musculoskeletal diseases and dermatological diseases as well. However, mechanisms by which balneotherapy may improve the clinical symptoms of patients have been less evaluated/ documented in the literature. Although the literature on mechanisms of action of balneotherapy has still been evolving and accumulating, some evidence from preliminary studies paves the way for generating a hypothesis that balneotherapy has an influence on physiological mechanisms, immune system, inflammation, and oxidative stress. Extrapolation of the evidence-based clinical practice and scientific experience of Europe, Turkey, and Israel to Central Asian spas and sanatoriums is although possible; future studies investigating clinical efficacy, safety profile, and possible mechanisms of action of balneotherapy of regional spas are needed to better understand the role of balneotherapy and whether it has any local differences.

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“…Here, patients with RA had more benefit from radon application, since the pain-relieving capacity lasted up to three months, while the effects in AS patients were diminished after three weeks [ 108 ]. A meta-analysis of several trials pointed out that the observed effects seem to be significantly triggered by bone restoration following radon exposure [ 109 ].…”

Section: Radon As a Therapeutic Agentmentioning

confidence: 99%

Radon Exposure—Therapeutic Effect and Cancer Risk

Maier

Wiedemann

Rapp

et al. 2020

IJMS

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Largely unnoticed, all life on earth is constantly exposed to low levels of ionizing radiation. Radon, an imperceptible natural occurring radioactive noble gas, contributes as the largest single fraction to radiation exposure from natural sources. For that reason, radon represents a major issue for radiation protection. Nevertheless, radon is also applied for the therapy of inflammatory and degenerative diseases in galleries and spas to many thousand patients a year. In either case, chronic environmental exposure or therapy, the effect of radon on the organism exposed is still under investigation at all levels of interaction. This includes the physical stage of diffusion and energy deposition by radioactive decay of radon and its progeny and the biological stage of initiating and propagating a physiologic response or inducing cancer after chronic exposure. The purpose of this manuscript is to comprehensively review the current knowledge of radon and its progeny on physical background, associated cancer risk and potential therapeutic effects.

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Rheumatic Diseases and Molecular Physical Medicine – New Aspects

Cited by 11 publications

References 24 publications

Serial whole-body cryotherapy in fibromyalgia is effective and alters cytokine profiles

Serial whole-body cryotherapy in fibromyalgia is effective and alters cytokine profiles

Pathophysiological Mechanisms of Balneotherapy With Potential Implications for Central Asian Spas and Sanatoriums

Radon Exposure—Therapeutic Effect and Cancer Risk

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