Rheumatic Fever Activity Determination by Two Correlative Methods

SKILLMAN, ROBERT K.

doi:10.1001/archinte.1955.04430010065007

Cited by 8 publications

(2 citation statements)

References 22 publications

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“…Both of these have been well studied in vitro, but some questions remain as to their occurrence in vivo. That indirect microbial hemagglutination can so occur is suggested by the experimental work of Boyden [3] and the observations of Skillman et al [26] in patients with rheumatic fever. Of the 21 cases of polyagglutination reported as occurring in vivo, several have been in some way identified with the T-phenomenon [2,14,15,251.…”

Section: Discussionmentioning

confidence: 89%

Occurrence of the Thomsen‐Friedenreich Phenomenon in vivo

Chorpenning¹,

Hayes

1959

Vox Sanguinis

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Summary Following Thomsen's description of polyagglutinable erythrocytes occurring in vitro (1927), there have appeared reports of 21 cases believed to be instances of the same phenomenon in vivo. Identity of the large majority of these has not been proven. A case is presented in which polyagglutinability occurred in association with severe peritonitis and pleuritis resulting from an infected pelvic hematoma. Initially, the patient's washed cells (group A) were agglutinated at 37° C. in all sera tested, including sera of groups A and AB. As the patient recovered, the percentage of reactive sera decreased. Human group 0 cells were experimentally altered with sterile culture filtrates of an organism isolated from the patient's blood and of an organism known to produce T‐transformation. In both instances the altered cell reactivity was similar to that of the patient's cells. Absorption of reactive sera with either of the experimental cells or with the patient's cells removed all T‐agglutinin. Absorption with either of the experimental cells failed to remove all reactivity for cells altered by the isolated organism, but did cause a reduction in strength. It is concluded that the patient's cells were T‐transformed (altered by bacterial enzyme) in vivo. An organism recovered from the patient may have been the etiologic agent since it was shown to be capable of causing such transformation; however, this is not proven. Résumé Depuis la description par Thomsen en 1927 d'hématies devenues polyagglutinables in vitro, 21 cas ont été communiqués dans lesquels ce phénoméne se serait produit in vivo. Cependant, dans la majorité de ces cas, il n'a pas été prouvé que l'altération des hématies eût été identique avec le phénomène de Thomsen. Un nouveau cas de ce genre est décrit; la malade souffrait de péritonite et de pleurésie graves, dont l'origine se trouvait dans un hématome infecté du bassin. Au début, les hématies lavées de la malade (groupe A) étaient agglutinées a 37° par tous les sérums examinés, y compris ceux de groupe A et AB. Plus tard, pendant la convalescence, le pourcentage des sérums donnant une agglutination diminua d'un examen à l'autre. Des hématies de groupe O furent traitées avec le filtrat stérile d'une culture d'organismes isolés du sang de la malade et avec le filtrat d'un organisme connu, capable de produire la «transformation T». Ces hématies transformées expérimentalement donnérent les mêmes réactions que celles de la malade. Certains des sérums actifs furent absorbés avec les hématies expérimentales et avec celles de la malade: les 3 types d'hématies entraînérent l'agglutinine T compkement. Lorsque ces sérums furent absorbés avec l'une ou l'autre des hématies expérimentales, il s'ensuivit une réduction, mais pas une disparition, du pouvoir agghtinant pour les hématies transformées par l'organisme isolé de la malade. Les auteurs concluent que les hématies de la malade avaient subi la transformation T (altération par enzyme bactériel) in vivo. L'organisme isolé de la malade peut bien avoir été la cause d...

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Section: Discussionmentioning

confidence: 89%

Occurrence of the Thomsen‐Friedenreich Phenomenon in vivo

Chorpenning¹,

Hayes

1959

Vox Sanguinis

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show abstract

Section: Discussionmentioning

confidence: 89%

Occurrence of the Thomsen-Friedenreich Phenomenon in vivo

Chorpenning¹,

Hayes²

1959

Vox Sanguinis

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The induction of erythrocyte panagglutinability by bacterial agents acting in vitro was described in 1925 by Heubener [16] and later by Thomsen [28]. Friedenreich [10] carried out extensive studies of the phenomenon and demonstrated the enzymatic nature of the agent. In the ensuing years twenty-one cases have been reported which are believed by some to be the examples of the occurrence of this phenomenon in vivo [18, 11, 1, 2, 9, 14, 19, 15, 12, 25, 22, 27, 20, 13]. The validity of the relationship of these cases to the Thomsen-Friedenreich phenomenon will be discussed later. The case being presented is an example of the Thomsen-Friedenreich phenomenon which occurred in vivo. The identity of the change in the patient’s cells with that of erythrocytes exhibiting Thomsen-Friedenreich transformation (T-transformation) was established by means of absorption experiments. Furthermore, a bacterium was isolated from the patient’s blood which is able to induce a similar transformation in normal human erythrocytes.

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Erkrankungen des Endokard

Schölmerich¹

1960

Rhythmus- Und Leitungsstörungen Traumatische Herzschädigungen Erkrankungen Des Endokard · Myokard · Perikard · Spezielle Kardio

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Rheumatic Fever Activity Determination by Two Correlative Methods

Cited by 8 publications

References 22 publications

Occurrence of the Thomsen‐Friedenreich Phenomenon in vivo

Occurrence of the Thomsen‐Friedenreich Phenomenon in vivo

Occurrence of the Thomsen-Friedenreich Phenomenon in vivo

Erkrankungen des Endokard

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