Rheumatic fever and post-streptococcal arthritis

Hilário, Maria Odete Esteves; Terreri, Maria Teresa

doi:10.1053/berh.2002.0255

Cited by 21 publications

(4 citation statements)

References 62 publications

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“…This is more frequently seen in the Indian population where unlike the western population the etiology is commonly rheumatic and presented at a younger age. [1] The significant reduction in mPAP post-induction in our study could be explained by relieving the vasoactive component of PH followed by relief of the obstructive component by MVR. On comparing both groups regarding their MAP at various stages of our study, we detected a significant difference post induction, being higher in the severe PH group.…”

Section: Discussionmentioning

confidence: 48%

“…The highest incidence is observed in children aged [5][6][7][8][9][10][11][12][13][14][15] years and in developing countries where medical health care is not easily approachable and the patient compliance is also less. [1] Hence, patients with mitral valve disease present in early phase of life for surgery, usually in the second to third decade of life. A large number of patients especially from rural areas present at a very late stage of the disease when the pulmonary artery pressure (PAP) is very high, at times nearing the systemic pressure.…”

Section: Introductionmentioning

confidence: 99%

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Mitral Valve Replacement in Severe Pulmonary Artery Hypertension — a Single Center Single Surgeon Experience

Yadav¹,

Rawat²

2018

AIMDR

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Background: Pulmonary artery hypertension (PAH) is a major risk factor in patients presenting in our hospital for mitral valve replacement (MVR) surgery. In this prospective study, we have focused on hemodynamic changes and postoperative results of MVR in patients with severe PAH. Methods: 136 consecutive patients who underwent mitral valve replacement for severe rheumatic mitral valve disease with severe PAH (pulmonary artery pressure (PAP) > 50 mmHg) were studied prospectively for immediate postoperative hemodynamics and outcomes from December 2013 to January 2016. The mean age of the patients was 34.3 years. 74 (54.41%) patients had mitral stenosis, 30 (22.05%) had mitral regurgitation and 32 (23.52%) had mixed lesions. Patients were randomly given two groups based on preoperative pulmonary artery pressures. In 120 patients (88.23%, group I) PAP was sub-systemic or systemic, with a mean of 59.6 mmHg. Sixteen patients (11.76%, group II) had supra-systemic PAP with a mean of 84.2 mmHg Results: After mitral valve replacement, the PAP and pulmonary vascular resistance (PVR) decreased significantly in group I to near normal levels. However, in group II, despite reduction in the PAP and PVR, significant residual PAH remained. Operative mortality was 1.6% in group I and 12.5% in group II. Conclusion: In patients with mitral valve disease undergoing mitral valve replacement, PAH is a significant risk factor. In cases with sub-systemic or systemic PAH, results are very good but significant PAH persists even after MVR is cases of supra-systemic PAH causing continuation of symptoms.

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Section: Discussionmentioning

confidence: 48%

Section: Introductionmentioning

confidence: 99%

Mitral Valve Replacement in Severe Pulmonary Artery Hypertension — a Single Center Single Surgeon Experience

Yadav¹,

Rawat²

2018

AIMDR

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“…RHD is most frequently found in children and adolescents. The recurrence is highest in people between the ages of 5-25 years and in impoverished or developing nations, where antibiotics are not frequently prescribed for pharyngitis, and compliance is poor (Hilário andTerreri 2002, Remenyi et al 2013). RHD has a significant impact on Sub-Saharan Africa, which is one of the most impacted regions (Mocumbi 2015, Yuyun et al 2020.…”

Section: Introductionmentioning

confidence: 99%

Characterization of rheumatic heart disease from electrocardiogram recordings

et al. 2023

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Objective: Rheumatic Heart Disease is one of the highly prevalent heart diseases in developing countries that can affect the pericardium, myocardium, or endocardium. Rheumatic endocarditis is a common RHD variant that gradually deteriorates the normal function of the heart valves. RHD can be diagnosed using standard echocardiography or listened to as a heart murmur using a stethoscope. The electrocardiogram is critical in the study and identification of heart rhythms and abnormalities. The effectiveness of ECG to identify distinguishing signs of RHD, however, has not been adequately examined. This study addressed the use of ECG recordings for the characterization of problems of the heart in RHD patients. Approach: An extensive ECG dataset was collected from patients suffering from RHD and healthy control subjects. Bandpass filtering was used at the preprocessing stage. Each data was then standardized by removing its mean and dividing by its standard deviation. Delineation of the onsets and offsets of waves was automatically performed. PR interval, QRS duration, RR intervals, QT intervals, and QTc intervals were computed for each heartbeat. The median values of the temporal parameters were used to eliminate possible outliers due to missed ECG waves. The data were clustered in different age groups and sex. Another categorization was done based on the time duration since the first RHD diagnosis. Main Results: In 47.2% of the cases, a PR elongation was observed, and in 26.4% of the cases, the QRS duration was elongated. QTc was elongated in 44.3% of the cases. It was also observed that 62.2% of the cases had bradycardia. Significance: The end product of this research can lead to new medical devices and services that can screen RHD based on ECG, which could assist in the detection and diagnosis of the disease in low-resource settings and alleviate the burden of the disease.

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“…Определение титров АСЛО используют для эпидемио логических исследований, а также диагностики стрептококковых инфекций и их осложнений, таких как острая ревматическая лихорадка, гломерулонефрит и реактивный артрит после воспалительных заболеваний глотки, вызванных стрептококком [9,10]. Стойкое и длительное повышение активности АСЛО после ангины может быть предвестником ревматического процесса [11].…”

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The significance of antistreptolysin O characteristics for the determination of indications for tonsillectomy in the children

Бойко

Kim

Stagnieva

et al. 2018

Vestn. otorinolaringol.

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The objective of the present work was to evaluate the diagnostic significance of the measurement of the antistreptolysin O (ASLO) titers in the children presenting with chronic tonsillitis for determining the indications for tonsillectomy. The study included 54 patients at the age varying from 4 to 17 years who had undergone bilateral tonsillectomy for the treatment of chronic tonsillitis. The diagnosis was confirmed by the results of the histological study of the removed amygdalae. Prior to surgery, all the patients had been subjected to the bacteriological investigation of the smears taken from the surface of the palatal tonsils. The titers of antistreptolysin O in the serum were determined with the use of the kinetic nephelometric technique before, 6 and 12 months after the surgical intervention. The results of the measurements were treated using the Statzilla software package (version 3.2, R Foundation for Statistical Computing, Vienna, Austria). Streptococcus pyogenes (group A) was identified only in 7 (13%) patients. The initially enhanced content of ASLO ranging from 273 to 1880 IU/ml was documented in 42 (77.7%) of the 54 patients. Twelve patients had the ASLO titers within the normal limits (from 13 to 124 IU/ml). The removal of palatal tonsils resulted in a significant decrease of the ASLO titers in the patients who had presented with the initially enhanced content of antistreptolysin O (p < 0.05); nevertheless, their ASLO titers remained higher than the normal values in 69% and 82% of the patients examined within 6 and 12 months after the surgical intervention, respectively. The patients who had exhibited the high levels of antistreptolysin O during the preoperative period did not experience normalization of this parameter after surgery. It is concluded, taking into account the absence of correlation between the enhancement of serum antistreptolysin O titers and the presence of group A beta-chemolytic Streptococci (BCSA), that the result of the measurement of ASLO titers can not be considered as a valid indication for tonsillectomy in the children.

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Rheumatic fever and post-streptococcal arthritis

Cited by 21 publications

References 62 publications

Mitral Valve Replacement in Severe Pulmonary Artery Hypertension — a Single Center Single Surgeon Experience

Mitral Valve Replacement in Severe Pulmonary Artery Hypertension — a Single Center Single Surgeon Experience

Characterization of rheumatic heart disease from electrocardiogram recordings

The significance of antistreptolysin O characteristics for the determination of indications for tonsillectomy in the children

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