Rheumatoid Arthritis and Associated Lung Diseases: A Comprehensive Review

Azam, Ahmad T; Odeyinka, Oladipo; Alhashimi, Rasha; Thoota, Sankeerth; Ashok, Tejaswini; Palyam, Vishnu; Sange, Ibrahim

doi:10.7759/cureus.22367

Cited by 5 publications

(4 citation statements)

References 83 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The result is the destruction of joint structure, and the inflammation of the synovial membrane by several immune cells, including macrophages, T and B cells, as well as the cytokines and matrix metalloproteinases (MMPs) released by them [ 1 ]. The progression of the illness can cause the systemic involvement of cardiovascular [ 2 , 3 ], respiratory [ 4 ], and renal tissue [ 5 ]. A basic determinant in RA diagnosis is the presence of rheumatoid factors (RFs) and anti-citrullinated peptide antibodies (ACPAs).…”

Section: Introductionmentioning

confidence: 99%

Infectious and Commensal Bacteria in Rheumatoid Arthritis—Role in the Outset and Progression of the Disease

Korzeniowska,

Bryl

2024

IJMS

View full text Add to dashboard Cite

Rheumatoid arthritis (RA) is a chronic, autoimmune disease with a complex outset. Besides the genetic susceptibility in its pathogenesis, various environmental factors also participate. Of these, in recent years, there have been increasing reports of the involvement of bacteria in the disease’s outset and development, especially gut microbiota and oral pathogens. Most recent reports about bacteria participation in RA pathogenesis focus on Prevotella copri and Porphyromonas gingivalis. There are also reports about the involvement of respiratory and urinary tract pathogens. The exact mechanisms leading to RA development used by bacteria are not well known; however, some mechanisms by which bacteria can interact with the immune system are known and can potentially lead to RA development. The aim of this study is to provide a comprehensive review of the potential bacteria participating in RA development and the mechanism involved in that process.

show abstract

Section: Introductionmentioning

confidence: 99%

Infectious and Commensal Bacteria in Rheumatoid Arthritis—Role in the Outset and Progression of the Disease

Korzeniowska,

Bryl

2024

IJMS

View full text Add to dashboard Cite

show abstract

“…Respiratory system involvement usually appears in the first 5 years of RA diagnosis as interstitial lung disease, pleural effusion, pleuritis, or rheumatoid pulmonary nodules 6,7–9,11 . Of all the respiratory EAMs, rheumatoid pulmonary nodules are rarest 12–14 .…”

Section: Introductionmentioning

confidence: 99%

“…3 Respiratory system involvement usually appears in the first 5 years of RA diagnosis as interstitial lung disease, pleural effusion, pleuritis, or rheumatoid pulmonary nodules. 6,[7][8][9]11 Of all the respiratory EAMs, rheumatoid pulmonary nodules are rarest. [12][13][14] For example, Kondo and colleagues mention a 75-year-old female patient with rheumatoid lung nodules on etanercept treatment.…”

mentioning

confidence: 99%

A case report of extra‐articular manifestation of rheumatoid arthritis: Rheumatoid nodules in lungs

Bektyrganova,

Kozhakhmet,

Kim

et al. 2023

Int J of Rheum Dis

View full text Add to dashboard Cite

Rheumatoid arthritis is a systemic inflammatory disorder primarily affecting joints but not limited to the joints alone. Extra‐articular manifestations involve skin, ocular, gastrointestinal, pulmonary, cardiac, renal, neurological, and hematological systems. Among them, skin manifestations (20%) are most common, presenting as nodules on the extensor surfaces of the upper and lower extremities. In rare cases these nodules can also be detected within the heart and lungs. Interestingly, rheumatoid nodules are often seen in patients on leflunomide, methotrexate, or tumor necrosis factor‐alpha antagonists. Nevertheless, definitive diagnosis requires a histopathological analysis. In this case report, we presented a 49‐year‐old male patient with a relatively short period of disease activity leading to rheumatoid nodules in the lungs. Considering the ongoing COVID‐19 pandemic and that tuberculosis was still endemic in Kazakhstan, achieving the definite diagnosis was challenging. Initial imaging study revealed bilateral polysegmental pneumonia. The tests for COVID‐19 and pulmonary tuberculosis were negative. A follow‐up chest computed tomography scan had signs of disseminated lung lesions of unknown origin. Lung biopsy showed a morphological picture of productive granulomas characteristic for tuberculosis. However, at the second look, typical scarring granulomas typically seen in rheumatoid nodules were observed.

show abstract

“…Interstitial lung disease in RA includes usual interstitial pneumonia (UIP) and nonspecific interstitial pneumonia (NSIP); RA patients with UIP are associated with a poor prognosis [5]. AD is also frequently detected in RA [6][7][8][9] and worsens its prognosis [10,11]. Thus, it is necessary to clarify the pathogenesis of interstitial lung disease and AD in RA.…”

Section: Introductionmentioning

confidence: 99%

Association of a Single Nucleotide Variant in TERT with Airway Disease in Japanese Rheumatoid Arthritis Patients

Higuchi,

Oka,

Furukawa

et al. 2023

Genes

View full text Add to dashboard Cite

Interstitial lung disease and airway disease (AD) are often complicated with rheumatoid arthritis (RA) and have a poor prognosis. Several studies reported genetic associations with interstitial lung disease in RA. However, few genetic studies have examined the susceptibility to AD in RA patients. Here, we investigated whether single nucleotide variants susceptible to idiopathic pulmonary fibrosis might be associated with interstitial lung disease or AD in Japanese RA patients. Genotyping of rs2736100 [C/A] in TERT and rs1278769 [G/A] in ATP11A was conducted in 98 RA patients with usual interstitial pneumonia, 120 with nonspecific interstitial pneumonia (NSIP), 227 with AD, and 422 without chronic lung disease using TaqMan assays. An association with AD in RA was found for rs2736100 (p = 0.0043, Pc = 0.0129, odds ratio [OR] 1.40, 95% confidence interval [CI] 1.11–1.77). ATP11A rs1278769 was significantly associated with NSIP in older RA patients (>65 years, p = 0.0010, OR 2.15, 95% CI 1.35–3.40). This study first reported an association of rs2736100 with AD in RA patients and ATP11A rs1278769 with NSIP in older RA patients.

show abstract

Rheumatoid Arthritis and Associated Lung Diseases: A Comprehensive Review

Cited by 5 publications

References 83 publications

Infectious and Commensal Bacteria in Rheumatoid Arthritis—Role in the Outset and Progression of the Disease

Infectious and Commensal Bacteria in Rheumatoid Arthritis—Role in the Outset and Progression of the Disease

A case report of extra‐articular manifestation of rheumatoid arthritis: Rheumatoid nodules in lungs

Association of a Single Nucleotide Variant in TERT with Airway Disease in Japanese Rheumatoid Arthritis Patients

Contact Info

Product

Resources

About