Rheumatoid arthritis and cognitive decline

Hugon, Jacques

doi:10.1016/j.jbspin.2022.105346

Cited by 11 publications

(8 citation statements)

References 11 publications

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“…To control for potential confounders, we included the following covariates:Age[18], Gender [2], Ethnicity [2], Education [19], Income [2], Smoke [20], Alcohol [21,22], BMI [23], Hypertension [24], High Cholesterol [25], bloodglucose [26]. These confounders were chosen to consider possible associations with the prevalence of RA.…”

Section: Other Covariates Used In Nhanesmentioning

confidence: 99%

Association between total protein, albumin, globulin, albumin- globulin ratio and rheumatoid arthritis: evidence from NHANES and Mendelian randomization

Liu,

Zhang,

Zhao

et al. 2024

Preprint

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Background With the increasing incidence of rheumatoid arthritis (RA) and the increasing percentage of serum RF negativity, there is an urgent need for more and more accurate methods for the early diagnosis and prevention of RA, among which serum proteins are closely related to the development of RA and are expected to become new auxiliary diagnostic tools, but their relationship with RA is not clear, so this study aimed to investigate the causal relationship between total protein (TP), albumin (ALB), globulin ( GLB), and albumin-globulin ratio (A/G) on the causal relationship of rheumatoid arthritis (RA). Methods In this study, the relationship between TP, ALB, GLB, A/G and rheumatoid arthritis was comprehensively evaluated by generalized linear modeling and smoothed curve fitting through the data of serum proteins and RA in the NHANES(National Health and Nutrition Examination Survey) database; moreover, for the positive results with significant associations, the inverse variance weighted (IVW) method in Mendelian Randomization (MR) was used in conjunction with the other four methods to further validate and clarify the causative relationship, and finally, the results were subjected to the inspection of heterogeneity and horizontal polytomousness in order to assess whether the results were robust. Results In the observational study, after correction for confounders, TP, GLB, and A/G were not significantly associated with rheumatoid arthritis, whereas ALB was significantly negatively associated with rheumatoid arthritis (OR = 0.662, [95%CI = 0.507–0.864], P = 0.003), and subgroup analyses showed significant negative associations in both males and females (male : OR = 0.674, [95%CI = 0.458–0.991], P = 0.047; females: OR = 0.661, [95%CI = 0.437–0.999], P = 0.049). In further MR analysis, IVW: ALB on RA, OR = 0.70 [95%0.52–0.93], P = 0.013; RA on ALB, OR = 0.95 [95%CI = 0.93–0.98], P < 0.001.The results of the MR analyses remained consistent with NHANES. Conclusion There is a significant relationship between ALB and RA, and the reduction of ALB may be one of the risk factors for RA, as well as one of the outcomes in the development of RA.

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Section: Other Covariates Used In Nhanesmentioning

confidence: 99%

Association between total protein, albumin, globulin, albumin- globulin ratio and rheumatoid arthritis: evidence from NHANES and Mendelian randomization

Liu,

Zhang,

Zhao

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…Researchers have found that people with rheumatoid arthritis have a 61% increased risk of developing Alzheimer's, and the cohort study showed middle-aged RA patients have twice the risk of cognitive impairment after 20 years [ 4 ]. Currently, most studies have used neuropsychiatric scales to prove cognitive dysfunction in RA patients [ 2 , 5 , 6 ]. An fMRI investigation discovered higher brain connectivity between the medial prefrontal gyrus, inferior parietal lobule, and various brain networks, which predicted fatigue, pain and cognitive dysfunction [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Functional dysconnectivity and microstructural impairment of the cortico-thalamo-cortical network in women with rheumatoid arthritis: A multimodal MRI study

Zheng,

Xie,

Huang

et al. 2024

Heliyon

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“…[ 1 , 2 ] Its occurrence registers 2 to 3 times higher among women in comparison to men. [ 3 ] Familial factors contribute to the condition in 40% to 65% of seropositive patients and 20% of seronegative patients. [ 4 ] The 2010 edition of RA diagnostic criteria comprises 4 facets: joint engagement, serological anomalies ascertained through RFs and ACPAs assessments, heightened indicators of acute inflammatory response, and arthritis duration.…”

Section: Introductionmentioning

confidence: 99%

Global research trends in DNA methylation in rheumatoid arthritis: A bibliometric analysis and visual analysis

Huang,

Gao

et al. 2024

Medicine

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Rheumatoid arthritis (RA) is a prevalent autoimmune disorder with a significant global economic burden. Epigenetic modifications, particularly DNA methylation, play a crucial role in RA. This study conducted a bibliometric analysis to explore the evolving trends and predominant themes in RA and DNA methylation research over the past two decades. A total of 1800 articles met the inclusion criteria, and the analysis revealed consistent growth in the literature, with a notable increase in output after 2019. The research involved 70 countries, 2139 academic institutions, 23,365 unique authors, and 58,636 co-cited authors. The United States emerged as a dominant contributor in this research domain. The significance of DNA methylation in shaping research directions for RA management is increasingly evident. Recent investigations have shed light on the pivotal role of DNA methylation in RA, particularly in characterizing synovial tissue and exploring the underlying mechanisms of disease pathogenesis. This study provides valuable insights into the landscape of DNA methylation research in RA and highlights the importance of epigenetics in autoimmune diseases.

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Rheumatoid arthritis and cognitive decline

Cited by 11 publications

References 11 publications

Association between total protein, albumin, globulin, albumin- globulin ratio and rheumatoid arthritis: evidence from NHANES and Mendelian randomization

Association between total protein, albumin, globulin, albumin- globulin ratio and rheumatoid arthritis: evidence from NHANES and Mendelian randomization

Functional dysconnectivity and microstructural impairment of the cortico-thalamo-cortical network in women with rheumatoid arthritis: A multimodal MRI study

Global research trends in DNA methylation in rheumatoid arthritis: A bibliometric analysis and visual analysis

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