Rheumatoid Arthritis and the Positive L.E.-Cell Phenomenon

A Clinical Study of Serum Antinuclear Factor

“…Our work does not enable us to draw any final conclusions on this point, because in many of the cases studied only serum, not fresh blood, was available, and therefore it was often possible to carry out L.E.-cell tests only by an indirect method. Studies which have revealed a high incidence of positive L.E.-cell tests in rheumatoid arthritis, for example, have used a sensitive direct method for the L.E.-cell test (Kievits et al, 1956). In our hands, nevertheless, A.N.F.…”

Fluorescent Antiglobulin Studies in Leukopenic and Related Disorders *

“…It is well recognized that a positive L.E. cell test can be obtained in rheumatoid arthritis (54,(62)(63)(64), particularly in Felty's syndrome (65). In addition, the presence of small quantities of "lupus globulin" has been detected in patients with rheumatoid arthritis (54).…”

Rheumatoid Arthritis and Systemic Lupus Erythematosus

“…Positive tests in patients not considered to have S.L.E. have been reported in haemolytic anaemia (Lee, Michael, and Vural, 1951), miliary tuberculosis (Lee and others, 1951;Jacobs, 1955), rheumatoid arthritis (Slocumb, 1953;Bywaters, 1956;Thomas and Morgan, 1956;Kievits, Goslings, Schuit, and Hijmans, 1956;Ross and Clardy, 1956), chronic hepatitis (Joske andKing, 1955, Mackay, Taft, andCowling, 1956), pernicious anaemia in relapse (Berman, Axelrod, Goodman, and McClaughry, 1950), subacute glomerulonephritis (Parelhoff, 1953), and sensitivity to various agents including nydantoin (Miescher and Delacretaz, 1953), penicillin (Walsh and Zimmerman, 1953), and hydralazine (Dustan, Taylor, Corcoran, and Page, 1954;Perry and Schroeder, 1954). In most of these case records there are clinical features which suggest S.L.E.…”